UniProtKB - E7ESZ3 (E7ESZ3_HUMAN)
Protein
Submitted name:
Pleckstrin homology domain-containing family G member 2
Gene
PLEKHG2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Pleckstrin homology domain-containing family G member 2Imported |
Gene namesi | Name:PLEKHG2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29515, PLEKHG2 |
VEuPathDBi | HostDB:ENSG00000090924.14 |
PTM / Processingi
Proteomic databases
MaxQBi | E7ESZ3 |
PeptideAtlasi | E7ESZ3 |
PRIDEi | E7ESZ3 |
ProteomicsDBi | 18091 |
Expressioni
Gene expression databases
Bgeei | ENSG00000090924, Expressed in sural nerve and 156 other tissues |
ExpressionAtlasi | E7ESZ3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 224 | DHInterPro annotationAdd BLAST | 182 | |
Domaini | 254 – 352 | PHInterPro annotationAdd BLAST | 99 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 377 – 481 | DisorderedSequence analysisAdd BLAST | 105 | |
Regioni | 495 – 553 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 642 – 680 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 731 – 756 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 770 – 800 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 978 – 1038 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 1103 – 1132 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 1209 – 1237 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 978 – 1000 | PolarSequence analysisAdd BLAST | 23 |
Phylogenomic databases
GeneTreei | ENSGT00940000162093 |
Family and domain databases
CDDi | cd13243, PH_PLEKHG1_G2_G3, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR043324, PH_PLEKHG1_G2_G3 |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
E7ESZ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEGAQGLSL SKPSPSLGCG RRGEVCDCGT VCETRTGSAR PSRLERVARE
60 70 80 90 100
IVETERAYVR DLRSIVEDYL GPLLDGGVLG LSVEQVGTLF ANIEDIYEFS
110 120 130 140 150
SELLEDLENS SSAGGIAECF VQRSEDFDIY TLYCMNYPSS LALLRELSLS
160 170 180 190 200
PPAALWLQER QAQLRHSLPL QSFLLKPVQR ILKYHLLLQE LGKHWAEGPG
210 220 230 240 250
TGGREMVEEA IVSMTAVAWY INDMKRKQEH AARLQEVQRR LGGWTGPELS
260 270 280 290 300
AFGELVLEGA FRGGGGGGPR LRGGERLLFL FSRMLLVAKR RGLEYTYKGH
310 320 330 340 350
IFCCNLSVSE SPRDPLGFKV SDLTIPKHRH LLQAKNQEEK RLWIHCLQRL
360 370 380 390 400
FFENHPASIP AKAKQVLLEN SLHCAPKSKP VLEPLTPPLG SPRPRDARSF
410 420 430 440 450
TPGRRNTAPS PGPSVIRRGR RQSEPVKDPY VMFPQNAKPG FKHAGSEGEL
460 470 480 490 500
YPPESQPPVS GSAPPEDLED AGPPTLDPSG TSITEEILEL LNQRGLRDPG
510 520 530 540 550
PSTHDIPKFP GDSQVPGDSE TLTFQALPSR DSSEEEEEEE EGLEMDERGP
560 570 580 590 600
SPLHVLEGLE SSIAAEMPSI PCLTKIPDVP NLPEIPSRCE IPEGSRLPSL
610 620 630 640 650
SDISDVFEMP CLPAIPSVPN TPSLSSTPTL SCDSWLQGPL QEPAEAPATR
660 670 680 690 700
RELFSGSNPG KLGEPPSGGK AGPEEDEEGV SFTDFQPQDV TQHQGFPDEL
710 720 730 740 750
AFRSCSEIRS AWQALEQGQL ARPGFPEPLL ILEDSDLGGD SGSGKAGAPS
760 770 780 790 800
SERTASRVRE LARLYSERIQ QMQRAETRAS ANAPRRRPRV LAQPQPSPCL
810 820 830 840 850
PQEQAEPGLL PAFGHVLVCE LAFPLTCAQE SVPLGPAVWV QAAIPLSKQG
860 870 880 890 900
GSPDGQGLHV SNLPKQDLPG IHVSAATLLP EQGGSRHVQA PAATPLPKQE
910 920 930 940 950
GPLHLQVPAL TTFSDQGHPE IQVPATTPLP EHRSHMVIPA PSTAFCPEQG
960 970 980 990 1000
HCADIHVPTT PALPKEICSD FTVSVTTPVP KQEGHLDSES PTNIPLTKQG
1010 1020 1030 1040 1050
GSRDVQGPDP VCSQPIQPLS WHGSSLDPQG PGDTLPPLPC HLPDLQIPGT
1060 1070 1080 1090 1100
SPLPAHGSHL DHRIPANAPL SLSQELPDTQ VPATTPLPLP QVLTDIWVQA
1110 1120 1130 1140 1150
LPTSPKQGSL PDIQGPAAAP PLPEPSLTDT QVQKLTPSLE QKSLIDAHVP
1160 1170 1180 1190 1200
AATPLPERGG SLDIQGLSPT PVQTTMVLSK PGGSLASHVA RNLWAFTGPR
1210 1220 1230
GLLMPPSTCE PGHEASLKQG FQPDAIDPQN LTWKSRH
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9H7P9 | PKHG2_HUMAN | Pleckstrin homology domain-containi... | PLEKHG2 | 1,386 | Annotation score: | ||
C9JVL3 | C9JVL3_HUMAN | Pleckstrin homology domain-containi... | PLEKHG2 | 198 | Annotation score: | ||
H7BXC7 | H7BXC7_HUMAN | Pleckstrin homology domain-containi... | PLEKHG2 | 1,254 | Annotation score: | ||
C9J7S4 | C9J7S4_HUMAN | Pleckstrin homology domain-containi... | PLEKHG2 | 127 | Annotation score: | ||
M0QX05 | M0QX05_HUMAN | Pleckstrin homology domain-containi... | PLEKHG2 | 115 | Annotation score: | ||
M0QZT7 | M0QZT7_HUMAN | Pleckstrin homology domain-containi... | PLEKHG2 | 153 | Annotation score: | ||
M0R348 | M0R348_HUMAN | Pleckstrin homology domain-containi... | PLEKHG2 | 84 | Annotation score: | ||
M0R391 | M0R391_HUMAN | Pleckstrin homology domain-containi... | PLEKHG2 | 48 | Annotation score: | ||
M0R3J0 | M0R3J0_HUMAN | Pleckstrin homology domain-containi... | PLEKHG2 | 103 | Annotation score: | ||
M0R3G5 | M0R3G5_HUMAN | Pleckstrin homology domain-containi... | PLEKHG2 | 95 | Annotation score: | ||
There is more potential isoformShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011500 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000458508; ENSP00000408857; ENSG00000090924 |
UCSCi | uc010xuy.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011500 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | E7ESZ3 |
PeptideAtlasi | E7ESZ3 |
PRIDEi | E7ESZ3 |
ProteomicsDBi | 18091 |
Protocols and materials databases
Antibodypediai | 30324, 47 antibodies |
Genome annotation databases
Ensembli | ENST00000458508; ENSP00000408857; ENSG00000090924 |
UCSCi | uc010xuy.3, human |
Organism-specific databases
HGNCi | HGNC:29515, PLEKHG2 |
OpenTargetsi | ENSG00000090924 |
VEuPathDBi | HostDB:ENSG00000090924.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000162093 |
Miscellaneous databases
ChiTaRSi | PLEKHG2, human |
Gene expression databases
Bgeei | ENSG00000090924, Expressed in sural nerve and 156 other tissues |
ExpressionAtlasi | E7ESZ3, baseline and differential |
Family and domain databases
CDDi | cd13243, PH_PLEKHG1_G2_G3, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR043324, PH_PLEKHG1_G2_G3 |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7ESZ3_HUMAN | |
Accessioni | E7ESZ3Primary (citable) accession number: E7ESZ3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | April 7, 2021 | |
This is version 74 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |