UniProtKB - E7ESS1 (E7ESS1_HUMAN)
Cellular tumor antigen p53
TP53
Functioni
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
UniRule annotationCofactori
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- transcription cis-regulatory region binding Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: UniProt
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotation |
Biological process | ApoptosisUniRule annotationARBA annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Cellular tumor antigen p53UniRule annotation |
Gene namesi | Name:TP53Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11998, TP53 |
VEuPathDBi | HostDB:ENSG00000141510 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationPTM / Processingi
Keywords - PTMi
Isopeptide bondARBA annotationProteomic databases
MaxQBi | E7ESS1 |
PeptideAtlasi | E7ESS1 |
ProteomicsDBi | 18045 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141510, Expressed in epithelium of mammary gland and 188 other tissues |
ExpressionAtlasi | E7ESS1, baseline and differential |
Interactioni
Subunit structurei
Binds DNA as a homotetramer.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 156 | P53InterPro annotationAdd BLAST | 156 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 151 – 199 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 151 – 169 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 173 – 187 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00950000183153 |
HOGENOMi | CLU_019621_0_0_1 |
OMAi | FHKKGEP |
Family and domain databases
CDDi | cd08367, P53, 1 hit |
Gene3Di | 2.60.40.720, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR002117, p53_tumour_suppressor |
PANTHERi | PTHR11447, PTHR11447, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SUPFAMi | SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MFCQLAKTCP VQLWVDSTPP PGTRVRAMAI YKQSQHMTEV VRRCPHHERC
60 70 80 90 100
SDSDGLAPPQ HLIRVEGNLR VEYLDDRNTF RHSVVVPYEP PEVGSDCTTI
110 120 130 140 150
HYNYMCNSSC MGGMNRRPIL TIITLEDSSG NLLGRNSFEV RVCACPGRDR
160 170 180 190
RTEEENLRKK GEPHHELPPG STKRALPNNT SSSPQPKKKP LDGEYFTLQ
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP04637 | P53_HUMAN | Cellular tumor antigen p53 | TP53 P53 | 393 | Annotation score: | ||
E7EQX7 | E7EQX7_HUMAN | Cellular tumor antigen p53 | TP53 | 285 | Annotation score: | ||
J3KP33 | J3KP33_HUMAN | Cellular tumor antigen p53 | TP53 | 343 | Annotation score: | ||
E7EMR6 | E7EMR6_HUMAN | Cellular tumor antigen p53 | TP53 | 165 | Annotation score: | ||
S4R334 | S4R334_HUMAN | Cellular tumor antigen p53 | TP53 | 143 | Annotation score: | ||
A0A0U1RQC9 | A0A0U1RQC9_HUMAN | Cellular tumor antigen p53 | TP53 | 410 | Annotation score: | ||
A0A087X1Q1 | A0A087X1Q1_HUMAN | Cellular tumor antigen p53 | TP53 | 234 | Annotation score: | ||
E9PFT5 | E9PFT5_HUMAN | Cellular tumor antigen p53 | TP53 | 155 | Annotation score: | ||
E9PCY9 | E9PCY9_HUMAN | Cellular tumor antigen p53 | TP53 | 127 | Annotation score: | ||
A0A087WT22 | A0A087WT22_HUMAN | Cellular tumor antigen p53 | TP53 | 187 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 199 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007421 Genomic DNA No translation available. AC087388 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000509690; ENSP00000425104; ENSG00000141510 |
UCSCi | uc060auy.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007421 Genomic DNA No translation available. AC087388 Genomic DNA No translation available. |
3D structure databases
SMRi | E7ESS1 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E7ESS1 |
PeptideAtlasi | E7ESS1 |
ProteomicsDBi | 18045 |
Protocols and materials databases
Antibodypediai | 3525, 9276 antibodies from 63 providers |
Genome annotation databases
Ensembli | ENST00000509690; ENSP00000425104; ENSG00000141510 |
UCSCi | uc060auy.1, human |
Organism-specific databases
HGNCi | HGNC:11998, TP53 |
OpenTargetsi | ENSG00000141510 |
VEuPathDBi | HostDB:ENSG00000141510 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000183153 |
HOGENOMi | CLU_019621_0_0_1 |
OMAi | FHKKGEP |
Miscellaneous databases
ChiTaRSi | TP53, human |
Gene expression databases
Bgeei | ENSG00000141510, Expressed in epithelium of mammary gland and 188 other tissues |
ExpressionAtlasi | E7ESS1, baseline and differential |
Family and domain databases
CDDi | cd08367, P53, 1 hit |
Gene3Di | 2.60.40.720, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR002117, p53_tumour_suppressor |
PANTHERi | PTHR11447, PTHR11447, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SUPFAMi | SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E7ESS1_HUMAN | |
Accessioni | E7ESS1Primary (citable) accession number: E7ESS1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | January 19, 2022 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |