UniProtKB - E7ESP9 (E7ESP9_HUMAN)
Protein
160 kDa neurofilament protein
Gene
NEFM
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- structural molecule activity Source: InterPro
GO - Biological processi
- neurofilament bundle assembly Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: 160 kDa neurofilament proteinARBA annotationAlternative name(s): Neurofilament 3ARBA annotation Neurofilament medium polypeptideARBA annotation Neurofilament triplet M proteinARBA annotation |
Gene namesi | Name:NEFMImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7734, NEFM |
VEuPathDBi | HostDB:ENSG00000104722.13 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Other locations
- axon ARBA annotation
Cytoskeleton
- intermediate filament cytoskeleton Source: HPA
- neurofilament Source: InterPro
Other locations
- axon Source: UniProtKB-SubCell
Keywords - Cellular componenti
Intermediate filamentUniRule annotationARBA annotationPTM / Processingi
Keywords - PTMi
AcetylationARBA annotation, GlycoproteinARBA annotationProteomic databases
EPDi | E7ESP9 |
MaxQBi | E7ESP9 |
PeptideAtlasi | E7ESP9 |
PRIDEi | E7ESP9 |
ProteomicsDBi | 18034 |
Expressioni
Gene expression databases
Bgeei | ENSG00000104722, Expressed in dorsal root ganglion and 176 other tissues |
ExpressionAtlasi | E7ESP9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 101 – 412 | IF rodInterPro annotationAdd BLAST | 312 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 51 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 485 – 812 | DisorderedSequence analysisAdd BLAST | 328 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 119 – 146 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 154 – 244 | Sequence analysisAdd BLAST | 91 | |
Coiled coili | 296 – 383 | Sequence analysisAdd BLAST | 88 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 504 – 522 | PolyampholyteSequence analysisAdd BLAST | 19 | |
Compositional biasi | 523 – 545 | AcidicSequence analysisAdd BLAST | 23 | |
Compositional biasi | 546 – 562 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 563 – 579 | AcidicSequence analysisAdd BLAST | 17 | |
Compositional biasi | 580 – 701 | PolyampholyteSequence analysisAdd BLAST | 122 | |
Compositional biasi | 713 – 791 | PolyampholyteSequence analysisAdd BLAST | 79 |
Sequence similaritiesi
Belongs to the intermediate filament family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000154418 |
OMAi | TTYQDTI |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR006821, Intermed_filament_DNA-bd IPR002957, Keratin_I IPR027697, NF-M |
PANTHERi | PTHR45652:SF3, PTHR45652:SF3, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit PF04732, Filament_head, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
E7ESP9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSYTLDSLGN PSAYRRVTET RSSFSRVSGS PSSGFRSQSW SRGSPSTVSS
60 70 80 90 100
SYKRSMLAPR LAYSSAMLSS AESSLDFSQS SSLLNGGSGP GGDYKLSRSN
110 120 130 140 150
EKEQLQGLND RFAGYIEKVH YLEQQNKEIE AEIQALRQKQ ASHAQLGDAY
160 170 180 190 200
DQEIRELRAT LEMVNHEKAQ VQLDSDHLEE DIHRLKERFE EEARLRDDTE
210 220 230 240 250
AAIRALRKDI EEASLVKVEL DKKVQSLQDE VAFLRSNHEE EVADLLAQIQ
260 270 280 290 300
ASHITVERKD YLKTDISTAL KEIRSQLESH SDQNMHQAEE WFKCRYAKLT
310 320 330 340 350
EAAEQNKEAI RSAKEEIAEY RRQLQSKSIE LESVRGTKES LERQLSDIEE
360 370 380 390 400
RHNHDLSSYQ DTIQQLENEL RGTKWEMARH LREYQDLLNV KMALDIEIAA
410 420 430 440 450
YRKLLEGEET RFSTFAGSIT GPLYTHRPPI TISSKIQKPK VEAPKLKVQH
460 470 480 490 500
KFVEEIIEET KVEDEKSEME EALTAITEEL AVSMKEEKKE AAEEKEEEPE
510 520 530 540 550
AEEEEVAAKK SPVKATAPEV KEEEGEKEEE EGQEEEEEED EGAKSDQAEE
560 570 580 590 600
GGSEKEGSSE KEEGEQEEGE TEAEAEGEEA EAKEEKKVEE KSEEVATKEE
610 620 630 640 650
LVADAKVEKP EKAKSPVPKS PVEEKGKSPV SKSPVEEKAK SPVPKSPVEE
660 670 680 690 700
AKSKAEVGKG EQKEEEEKEV KEAPKEEKVE KKEEKPKDVP EKKKAESPVK
710 720 730 740 750
EEAVAEVVTI TKSVKVHLEK ETKEEGKPLQ QEKEKEKAGG EGGSEEEGSD
760 770 780 790 800
KGAKGSRKED IAVNGEVEGK EEVEQETKEK GSGREEEKGV VTNGLDLSPA
810 820 830 840 850
DEKKGGDKSE EKVVVTKTVE KITSEGGDGA TKYITKSVTV TQKVEEHEET
860 870
FEEKLVSTKK VEKVTSHAIV KEVTQSD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP07197 | NFM_HUMAN | Neurofilament medium polypeptide | NEFM NEF3, NFM | 916 | Annotation score: | ||
E7EMV2 | E7EMV2_HUMAN | 160 kDa neurofilament protein | NEFM | 698 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF106564 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000437366; ENSP00000410137; ENSG00000104722 |
UCSCi | uc064lha.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF106564 Genomic DNA No translation available. |
3D structure databases
SMRi | E7ESP9 |
ModBasei | Search... |
Proteomic databases
EPDi | E7ESP9 |
MaxQBi | E7ESP9 |
PeptideAtlasi | E7ESP9 |
PRIDEi | E7ESP9 |
ProteomicsDBi | 18034 |
Protocols and materials databases
Antibodypediai | 4396, 689 antibodies |
Genome annotation databases
Ensembli | ENST00000437366; ENSP00000410137; ENSG00000104722 |
UCSCi | uc064lha.1, human |
Organism-specific databases
HGNCi | HGNC:7734, NEFM |
OpenTargetsi | ENSG00000104722 |
VEuPathDBi | HostDB:ENSG00000104722.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154418 |
OMAi | TTYQDTI |
Miscellaneous databases
ChiTaRSi | NEFM, human |
Gene expression databases
Bgeei | ENSG00000104722, Expressed in dorsal root ganglion and 176 other tissues |
ExpressionAtlasi | E7ESP9, baseline and differential |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR006821, Intermed_filament_DNA-bd IPR002957, Keratin_I IPR027697, NF-M |
PANTHERi | PTHR45652:SF3, PTHR45652:SF3, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit PF04732, Filament_head, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7ESP9_HUMAN | |
Accessioni | E7ESP9Primary (citable) accession number: E7ESP9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | April 7, 2021 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |