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UniProtKB - E7ESA6 (E7ESA6_HUMAN)
Protein
Non-specific protein-tyrosine kinase
Gene
PTK2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.10.2ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 498 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
- protein serine/threonine/tyrosine kinase activity Source: RHEA
GO - Biological processi
- angiogenesis Source: UniProtKB-KW
- negative regulation of apoptotic process Source: UniProt
- positive regulation of cell population proliferation Source: UniProt
- positive regulation of protein phosphorylation Source: UniProt
- regulation of biological quality Source: UniProt
- regulation of cellular component organization Source: UniProt
- regulation of intracellular signal transduction Source: UniProt
- regulation of multicellular organismal process Source: UniProt
- response to stimulus Source: UniProt
- signal complex assembly Source: InterPro
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinaseARBA annotation |
Biological process | AngiogenesisARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PTK2 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9611, PTK2 |
VEuPathDBi | HostDB:ENSG00000169398 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Other locations
- focal adhesion ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Cytoskeleton
- cytoskeleton Source: InterPro
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell projection Source: UniProtKB-KW
- focal adhesion Source: HPA
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Cell junctionARBA annotation, Cell projectionARBA annotation, MembraneARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000169398, Expressed in corpus callosum and 241 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 79 – 399 | FERMInterPro annotationAdd BLAST | 321 | |
Domaini | 466 – 724 | Protein kinaseInterPro annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 728 – 778 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 883 – 966 | DisorderedSequence analysisAdd BLAST | 84 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 261 – 281 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 853 – 873 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 910 – 924 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 934 – 966 | Polar residuesSequence analysisAdd BLAST | 33 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155113 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13190, FERM_C_FAK1, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR041390, FADK_N IPR041784, FAK1/PYK2_FERM_C IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR036137, Focal_adhe_kin_target_dom_sf IPR005189, Focal_adhesion_kin_target_dom IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00373, FERM_M, 1 hit PF18038, FERM_N_2, 1 hit PF03623, Focal_AT, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit SSF68993, SSF68993, 1 hit |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 32 potential isoforms that are computationally mapped.Show allAlign All
E7ESA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLELAGQEA LKPAGAIYME KSGCSPFPVC WAKEYDRYLA SSKIMAAAYL
60 70 80 90 100
DPNLNHTPNS STKTHLGTGM ERSPGAMERV LKVFHYFESN SEPTTWASII
110 120 130 140 150
RHGDATDVRG IIQKIVDSHK VKHVACYGFR LSHLRSEEVH WLHVDMGVSS
160 170 180 190 200
VREKYELAHP PEEWKYELRI RYLPKGFLNQ FTEDKPTLNF FYQQVKSDYM
210 220 230 240 250
LEIADQVDQE IALKLGCLEI RRSYWEMRGN ALEKKSNYEV LEKDVGLKRF
260 270 280 290 300
FPKSLLDSVK AKTLRKLIQQ TFRQFANLNR EESILKFFEI LSPVYRFDKE
310 320 330 340 350
CFKCALGSSW IISVELAIGP EEGISYLTDK GCNPTHLADF TQVQTIQYSN
360 370 380 390 400
SEDKDRKGML QLKIAGAPEP LTVTAPSLTI AENMADLIDG YCRLVNGTSQ
410 420 430 440 450
SFIIRPQKEG ERALPSIPKL ANSEKQGMRT HAVSVSETDD YAEIIDEEDT
460 470 480 490 500
YTMPSTRDYE IQRERIELGR CIGEGQFGDV HQGIYMSPEN PALAVAIKTC
510 520 530 540 550
KNCTSDSVRE KFLQEALTMR QFDHPHIVKL IGVITENPVW IIMELCTLGE
560 570 580 590 600
LRSFLQVRKY SLDLASLILY AYQLSTALAY LESKRFVHRD IAARNVLVSS
610 620 630 640 650
NDCVKLGDFG LSRYMEDSTY YKASKGKLPI KWMAPESINF RRFTSASDVW
660 670 680 690 700
MFGVCMWEIL MHGVKPFQGV KNNDVIGRIE NGERLPMPPN CPPTLYSLMT
710 720 730 740 750
KCWAYDPSRR PRFTELKAQL STILEEEKAQ QEERMRMESR RQATVSWDSG
760 770 780 790 800
GSDEAPPKPS RPGYPSPRSS EGFYPSPQHM VQTNHYQVSG YPGSHGITAM
810 820 830 840 850
AGSIYPGQAS LLDQTDSWNH RPQEIAMWQP NVEDSTVLDL RGIGQVLPTH
860 870 880 890 900
LMEERLIRQQ QEMEEDQRWL EKEERFLKPD VRLSRGSIDR EDGSLQGPIG
910 920 930 940 950
NQHIYQPVGK PDPAAPPKKP PRPGAPGHLG SLASLSSPAD SYNEGVKLQP
960 970 980 990 1000
QEISPPPTAN LDRSNDKVYE NVTGLVKAVI EMSSKIQPAP PEEYVPMVKE
1010 1020 1030 1040 1050
VGLALRTLLA TVDETIPLLP ASTHREIEMA QKLLNSDLGE LINKMKLAQQ
1060 1070 1080 1090
YVMTSLQQEY KKQMLTAAHA LAVDAKNLLD VIDQARLKML GQTRPH
Computationally mapped potential isoform sequencesi
There are 32 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ05397 | FAK1_HUMAN | Focal adhesion kinase 1 | PTK2 FAK, FAK1 | 1,052 | Annotation score: | ||
H0YBP1 | H0YBP1_HUMAN | Non-specific protein-tyrosine kinas... | PTK2 | 1,017 | Annotation score: | ||
H0YB16 | H0YB16_HUMAN | Focal adhesion kinase 1 | PTK2 | 724 | Annotation score: | ||
H0YB99 | H0YB99_HUMAN | Non-specific protein-tyrosine kinas... | PTK2 | 319 | Annotation score: | ||
E9PEI4 | E9PEI4_HUMAN | Focal adhesion kinase 1 | PTK2 | 680 | Annotation score: | ||
H0YBZ1 | H0YBZ1_HUMAN | Focal adhesion kinase 1 | PTK2 | 753 | Annotation score: | ||
B4DWJ1 | B4DWJ1_HUMAN | Focal adhesion kinase 1 | PTK2 | 362 | Annotation score: | ||
E5RGA6 | E5RGA6_HUMAN | Focal adhesion kinase 1 | PTK2 | 156 | Annotation score: | ||
E5RJP0 | E5RJP0_HUMAN | Focal adhesion kinase 1 | PTK2 | 122 | Annotation score: | ||
E5RI29 | E5RI29_HUMAN | Focal adhesion kinase 1 | PTK2 | 124 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC067931 Genomic DNA No translation available. AC100860 Genomic DNA No translation available. AC105009 Genomic DNA No translation available. AC105235 Genomic DNA No translation available. KF458878 Genomic DNA No translation available. KF458882 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000517887.5; ENSP00000429082.1; ENSG00000169398.19 ENST00000519419.5; ENSP00000429129.1; ENSG00000169398.19 |
UCSCi | uc064qqo.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC067931 Genomic DNA No translation available. AC100860 Genomic DNA No translation available. AC105009 Genomic DNA No translation available. AC105235 Genomic DNA No translation available. KF458878 Genomic DNA No translation available. KF458882 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | E7ESA6, 1 interactor |
Proteomic databases
ProteomicsDBi | 17947 |
Protocols and materials databases
Antibodypediai | 725, 2885 antibodies from 48 providers |
Genome annotation databases
Ensembli | ENST00000517887.5; ENSP00000429082.1; ENSG00000169398.19 ENST00000519419.5; ENSP00000429129.1; ENSG00000169398.19 |
UCSCi | uc064qqo.1, human |
Organism-specific databases
HGNCi | HGNC:9611, PTK2 |
OpenTargetsi | ENSG00000169398 |
VEuPathDBi | HostDB:ENSG00000169398 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155113 |
Miscellaneous databases
ChiTaRSi | PTK2, human |
Gene expression databases
Bgeei | ENSG00000169398, Expressed in corpus callosum and 241 other tissues |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13190, FERM_C_FAK1, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR041390, FADK_N IPR041784, FAK1/PYK2_FERM_C IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR036137, Focal_adhe_kin_target_dom_sf IPR005189, Focal_adhesion_kin_target_dom IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00373, FERM_M, 1 hit PF18038, FERM_N_2, 1 hit PF03623, Focal_AT, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit SSF68993, SSF68993, 1 hit |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E7ESA6_HUMAN | |
Accessioni | E7ESA6Primary (citable) accession number: E7ESA6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | May 25, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |