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Protein
Submitted name:

Paired box protein Pax-5

Gene

PAX5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Paired box protein Pax-5Imported
Gene namesi
Name:PAX5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000196092.12
HGNCiHGNC:8619 PAX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196092

PTM / Processingi

Proteomic databases

MaxQBiE7ERK2
PeptideAtlasiE7ERK2
PRIDEiE7ERK2

Expressioni

Gene expression databases

BgeeiENSG00000196092 Expressed in 112 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiE7ERK2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE7ERK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 34PairedInterPro annotationAdd BLAST34

Keywords - Domaini

Paired boxPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3862 Eukaryota
ENOG410ZT0S LUCA
GeneTreeiENSGT00680000099553

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR022130 Pax2_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PF12403 Pax2_C, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51057 PAIRED_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

E7ERK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFAWEIRDRL LAERVCDNDT VPSVSSINRI IRTKVQQPPN QPVPASSHSI
60 70 80 90 100
VSTGSVTQVS SVSTDSAGSS YSISGILGIT SPSADTNKRK RDEGIQESPV
110 120 130 140 150
PNGHSLPGRD FLRKQMRGDL FTQQQLEVLD RVFERQHYSD IFTTTEPIKP
160 170 180 190 200
EQTTEYSAMA SLAGGLDDMK ANLASPTPAD IGSSVPGPQS YPIVTGRDLA
210 220 230 240 250
STTLPGYPPH VPPAGQGSYS APTLTGMVPG SEFSGSPYSH PQYSSYNDSW
260 270 280
RFPNPGLLGS PYYYSAAARG AAPPAAATAY DRH
Length:283
Mass (Da):30,321
Last modified:March 8, 2011 - v1
Checksum:i20828150572E66D5
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q02548PAX5_HUMAN
Paired box protein Pax-5
PAX5
391Annotation score:
E7EQT0E7EQT0_HUMAN
Paired box protein Pax-5
PAX5
324Annotation score:
E7ERW5E7ERW5_HUMAN
Paired box protein Pax-5
PAX5
295Annotation score:
E7ES87E7ES87_HUMAN
Paired box protein Pax-5
PAX5
220Annotation score:
C0KTE2C0KTE2_HUMAN
B cell specific activator protein v...
PAX5
218Annotation score:
H0YB47H0YB47_HUMAN
Paired box protein Pax-5
PAX5
60Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161781 Genomic DNA No translation available.
AL450267 Genomic DNA No translation available.
RefSeqiNP_001267485.1, NM_001280556.1
UniGeneiHs.654464

Genome annotation databases

EnsembliENST00000522003; ENSP00000429359; ENSG00000196092
GeneIDi5079
UCSCiuc011lqa.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161781 Genomic DNA No translation available.
AL450267 Genomic DNA No translation available.
RefSeqiNP_001267485.1, NM_001280556.1
UniGeneiHs.654464

3D structure databases

ProteinModelPortaliE7ERK2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE7ERK2
PeptideAtlasiE7ERK2
PRIDEiE7ERK2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000522003; ENSP00000429359; ENSG00000196092
GeneIDi5079
UCSCiuc011lqa.3 human

Organism-specific databases

CTDi5079
EuPathDBiHostDB:ENSG00000196092.12
HGNCiHGNC:8619 PAX5
OpenTargetsiENSG00000196092
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3862 Eukaryota
ENOG410ZT0S LUCA
GeneTreeiENSGT00680000099553

Miscellaneous databases

ChiTaRSiPAX5 human
GenomeRNAii5079

Gene expression databases

BgeeiENSG00000196092 Expressed in 112 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiE7ERK2 baseline and differential

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR022130 Pax2_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PF12403 Pax2_C, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51057 PAIRED_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE7ERK2_HUMAN
AccessioniPrimary (citable) accession number: E7ERK2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 12, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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