UniProtKB - E7ERK2 (E7ERK2_HUMAN)

BLAST

>tr|E7ERK2|E7ERK2_HUMAN Paired box protein Pax-5 OS=Homo sapiens OX=9606 GN=PAX5 PE=1 SV=1
MFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVS
SVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDL
FTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPAD
IGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSH
PQYSSYNDSWRFPNPGLLGSPYYYSAAARGAAPPAAATAYDRH

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History
Entry version 62 (12 Sep 2018)
Sequence version 1 (08 Mar 2011)
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Protein

Submitted name:

Paired box protein Pax-5

Gene

PAX5

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: UniProtKB-UniRule
transcription, DNA-templated Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingPROSITE-ProRule annotation
Biological process	Transcription, Transcription regulationPROSITE-ProRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Paired box protein Pax-5Imported
Gene namesⁱ	Name:PAX5Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196092.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8619 PAX5

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotation

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000196092

OpenTargetsⁱ

ENSG00000196092

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E7ERK2
PeptideAtlas More...PeptideAtlasⁱ	E7ERK2
PRIDEⁱ	E7ERK2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000196092 Expressed in 112 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasⁱ	E7ERK2 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E7ERK2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 34	PairedInterPro annotationAdd BLAST		34

Keywords - Domainⁱ

Paired boxPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3862 Eukaryota ENOG410ZT0S LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00680000099553

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001523 Paired_dom IPR022130 Pax2_C IPR036388 WH-like_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00292 PAX, 1 hit PF12403 Pax2_C, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51057 PAIRED_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

E7ERK2-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MFAWEIRDRL LAERVCDNDT VPSVSSINRI IRTKVQQPPN QPVPASSHSI 
        60         70         80         90        100
VSTGSVTQVS SVSTDSAGSS YSISGILGIT SPSADTNKRK RDEGIQESPV 
       110        120        130        140        150
PNGHSLPGRD FLRKQMRGDL FTQQQLEVLD RVFERQHYSD IFTTTEPIKP 
       160        170        180        190        200
EQTTEYSAMA SLAGGLDDMK ANLASPTPAD IGSSVPGPQS YPIVTGRDLA 
       210        220        230        240        250
STTLPGYPPH VPPAGQGSYS APTLTGMVPG SEFSGSPYSH PQYSSYNDSW 
       260        270        280 
RFPNPGLLGS PYYYSAAARG AAPPAAATAY DRH

Length:283

Mass (Da):30,321

Last modified:March 8, 2011 - v1

Checksum:ⁱ20828150572E66D5

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q02548	PAX5_HUMAN	Paired box protein Pax-5 Paired box protein Pax-5 (B-cell-specific transcription factor, BSAP)	PAX5	391	Annotation score:
E7EQT0	E7EQT0_HUMAN	Paired box protein Pax-5 Paired box protein Pax-5	PAX5	324	Annotation score:
E7ERW5	E7ERW5_HUMAN	Paired box protein Pax-5 Paired box protein Pax-5	PAX5	295	Annotation score:
E7ES87	E7ES87_HUMAN	Paired box protein Pax-5 Paired box protein Pax-5	PAX5	220	Annotation score:
C0KTE2	C0KTE2_HUMAN	B cell specific activator protein v... B cell specific activator protein variant insert 6/7 (Paired box protein Pax-5)	PAX5	218	Annotation score:
H0YB47	H0YB47_HUMAN	Paired box protein Pax-5 Paired box protein Pax-5	PAX5	60	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL161781 Genomic DNA No translation available. AL450267 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001267485.1, NM_001280556.1
UniGeneⁱ	Hs.654464

Genome annotation databases

Ensemblⁱ	ENST00000522003; ENSP00000429359; ENSG00000196092
GeneIDⁱ	5079
UCSC genome browser More...UCSCⁱ	uc011lqa.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
E7ERK2	Paired box protein Pax-5	)	HUMAN		391	UniRef100_Q02548
PAX5 isoform 1		PANTR		391
B-cell-specific transcription factor		MACMU		391
B-cell-specific transcription factor		MACFA		391
Paired box 5		SAIBB		391
+8

Protein	Similar proteins		Species	Score	Length	Source
E7ERK2	Paired box protein Pax-5	)	HUMAN		391	UniRef90_Q02548
Paired box protein Pax-5		MOUSE		391
PAX5 isoform 1		PANTR		391
B-cell-specific transcription factor		MACMU		391
B-cell-specific transcription factor		MACFA		391
+164

Protein	Similar proteins		Species	Score	Length	Source
E7ERK2	Isoform 9 of Paired box protein Pax-2a		DANRE		389	UniRef50_Q90268-9
Paired box protein Pax-5		MOUSE		391
Paired box protein Pax-5	)	HUMAN		391
paired box protein Pax-2 isoform X9		ICTPU		461
Uncharacterized protein		RABIT		448
+404

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL161781 Genomic DNA No translation available. AL450267 Genomic DNA No translation available.
RefSeqⁱ	NP_001267485.1, NM_001280556.1
UniGeneⁱ	Hs.654464

3D structure databases

ProteinModelPortalⁱ	E7ERK2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQBⁱ	E7ERK2
PeptideAtlasⁱ	E7ERK2
PRIDEⁱ	E7ERK2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000522003; ENSP00000429359; ENSG00000196092
GeneIDⁱ	5079
UCSCⁱ	uc011lqa.3 human

Organism-specific databases

CTDⁱ	5079
EuPathDBⁱ	HostDB:ENSG00000196092.12
HGNCⁱ	HGNC:8619 PAX5
OpenTargetsⁱ	ENSG00000196092
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3862 Eukaryota ENOG410ZT0S LUCA
GeneTreeⁱ	ENSGT00680000099553

Miscellaneous databases

ChiTaRSⁱ	PAX5 human
GenomeRNAiⁱ	5079

Gene expression databases

Bgeeⁱ	ENSG00000196092 Expressed in 112 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasⁱ	E7ERK2 baseline and differential

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001523 Paired_dom IPR022130 Pax2_C IPR036388 WH-like_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00292 PAX, 1 hit PF12403 Pax2_C, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51057 PAIRED_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E7ERK2_HUMAN
Accessionⁱ	E7ERK2Primary (citable) accession number: E7ERK2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 8, 2011
	Last sequence update:	March 8, 2011
	Last modified:	September 12, 2018
	This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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Supporting data

UniProtKB - E7ERK2 (E7ERK2_HUMAN)

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Paired box protein Pax-5

PAX5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ