UniProtKB - E7ERK2 (E7ERK2_HUMAN)
Protein
Submitted name:
Paired box protein Pax-5
Gene
PAX5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: InterPro
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Paired box protein Pax-5Imported |
Gene namesi | Name:PAX5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196092.12 |
HGNCi | HGNC:8619, PAX5 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: HPA
Nucleus
- fibrillar center Source: HPA
- nucleoplasm Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000196092, Expressed in buccal mucosa cell and 134 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 34 | PairedInterPro annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 78 – 110 | DisorderedSequence analysisAdd BLAST | 33 |
Keywords - Domaini
Paired boxARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159636 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001523, Paired_dom IPR022130, Pax2_C IPR043565, PAX_fam IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR45636, PTHR45636, 1 hit |
Pfami | View protein in Pfam PF00292, PAX, 1 hit PF12403, Pax2_C, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51057, PAIRED_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
E7ERK2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFAWEIRDRL LAERVCDNDT VPSVSSINRI IRTKVQQPPN QPVPASSHSI
60 70 80 90 100
VSTGSVTQVS SVSTDSAGSS YSISGILGIT SPSADTNKRK RDEGIQESPV
110 120 130 140 150
PNGHSLPGRD FLRKQMRGDL FTQQQLEVLD RVFERQHYSD IFTTTEPIKP
160 170 180 190 200
EQTTEYSAMA SLAGGLDDMK ANLASPTPAD IGSSVPGPQS YPIVTGRDLA
210 220 230 240 250
STTLPGYPPH VPPAGQGSYS APTLTGMVPG SEFSGSPYSH PQYSSYNDSW
260 270 280
RFPNPGLLGS PYYYSAAARG AAPPAAATAY DRH
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ02548 | PAX5_HUMAN | Paired box protein Pax-5 | PAX5 | 391 | Annotation score: | ||
E7EQT0 | E7EQT0_HUMAN | Paired box protein Pax-5 | PAX5 | 324 | Annotation score: | ||
E7ERW5 | E7ERW5_HUMAN | Paired box protein Pax-5 | PAX5 | 295 | Annotation score: | ||
E7ES87 | E7ES87_HUMAN | Paired box protein Pax-5 | PAX5 | 220 | Annotation score: | ||
H0YB47 | H0YB47_HUMAN | Paired box protein Pax-5 | PAX5 | 60 | Annotation score: | ||
C0KTE2 | C0KTE2_HUMAN | B cell specific activator protein v... | PAX5 | 218 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL161781 Genomic DNA No translation available. AL450267 Genomic DNA No translation available. |
RefSeqi | NP_001267485.1, NM_001280556.1 |
Genome annotation databases
Ensembli | ENST00000522003; ENSP00000429359; ENSG00000196092 ENST00000651550; ENSP00000498443; ENSG00000196092 |
GeneIDi | 5079 |
UCSCi | uc011lqa.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL161781 Genomic DNA No translation available. AL450267 Genomic DNA No translation available. |
RefSeqi | NP_001267485.1, NM_001280556.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | E7ERK2 |
PRIDEi | E7ERK2 |
ProteomicsDBi | 17800 |
Protocols and materials databases
Antibodypediai | 3668, 900 antibodies |
Genome annotation databases
Ensembli | ENST00000522003; ENSP00000429359; ENSG00000196092 ENST00000651550; ENSP00000498443; ENSG00000196092 |
GeneIDi | 5079 |
UCSCi | uc011lqa.3, human |
Organism-specific databases
CTDi | 5079 |
EuPathDBi | HostDB:ENSG00000196092.12 |
HGNCi | HGNC:8619, PAX5 |
OpenTargetsi | ENSG00000196092 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159636 |
Miscellaneous databases
BioGRID-ORCSi | 5079, 16 hits in 869 CRISPR screens |
ChiTaRSi | PAX5, human |
GenomeRNAii | 5079 |
Gene expression databases
Bgeei | ENSG00000196092, Expressed in buccal mucosa cell and 134 other tissues |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001523, Paired_dom IPR022130, Pax2_C IPR043565, PAX_fam IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR45636, PTHR45636, 1 hit |
Pfami | View protein in Pfam PF00292, PAX, 1 hit PF12403, Pax2_C, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51057, PAIRED_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7ERK2_HUMAN | |
Accessioni | E7ERK2Primary (citable) accession number: E7ERK2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |