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UniProtKB - E7EQA0 (E7EQA0_HUMAN)
Protein
Calpain inhibitor
Gene
CAST
Organism
Homo sapiens (Human)
Status
Functioni
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
ARBA annotationNames & Taxonomyi
Protein namesi | Recommended name: Calpain inhibitorARBA annotationAlternative name(s): CalpastatinARBA annotation |
Gene namesi | Name:CASTImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1515, CAST |
VEuPathDBi | HostDB:ENSG00000153113 |
PTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
MaxQBi | E7EQA0 |
PeptideAtlasi | E7EQA0 |
PRIDEi | E7EQA0 |
ProteomicsDBi | 17531 |
Expressioni
Gene expression databases
Bgeei | ENSG00000153113, Expressed in calcaneal tendon and 251 other tissues |
ExpressionAtlasi | E7EQA0, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 43 – 250 | DisorderedSequence analysisAdd BLAST | 208 | |
Regioni | 266 – 431 | DisorderedSequence analysisAdd BLAST | 166 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 43 – 117 | Basic and acidic residuesSequence analysisAdd BLAST | 75 | |
Compositional biasi | 160 – 220 | Basic and acidic residuesSequence analysisAdd BLAST | 61 | |
Compositional biasi | 266 – 282 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 284 – 373 | Basic and acidic residuesSequence analysisAdd BLAST | 90 | |
Compositional biasi | 413 – 431 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00390000002993 |
Family and domain databases
InterProi | View protein in InterPro IPR026998, Calpastatin IPR001259, Prot_inh_calpain |
PANTHERi | PTHR10077, PTHR10077, 1 hit |
Pfami | View protein in Pfam PF00748, Calpain_inhib, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 33 potential isoforms that are computationally mapped.Show allAlign All
E7EQA0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGQFLSSTFL EGSPATVWHD KLCDGERRGA REAVRIFQDQ AKAKEEKLEK
60 70 80 90 100
CGEDDETIPS EYRLKPATDK DGKPLLPEPE EKPKPRSESE LIDELSEDFD
110 120 130 140 150
RSECKEKPSK PTEKTEESKA AAPAPVSEAV CRTSMCSIQS APPEPATLKG
160 170 180 190 200
TVPDDAVEAL ADSLGKKEAD PEDGKPVMDK VKEKAKEEDR EKLGEKEETI
210 220 230 240 250
PPDYRLEEVK DKDGKPLLPK ESKEQLPPMS EDFLLDALSE DFSGPQNASS
260 270 280 290 300
LKFEDAKLAA AISEVVSQTP ASTTQAGAPP RDTSQSDKDL DDALDKLSDS
310 320 330 340 350
LGQRQPDPDE NKPMEDKVKE KAKAEHRDKL GERDDTIPPE YRHLLDDNGQ
360 370 380 390 400
DKPVKPPTKK SEDSKKPADD QDPIDALSGD LDSCPSTTET SQNTAKDKCK
410 420 430
KAASSSKAPK NGGKAKDSAK TTEETSKPKD D
Computationally mapped potential isoform sequencesi
There are 33 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP20810 | ICAL_HUMAN | Calpastatin | CAST | 708 | Annotation score: | ||
E9PCH5 | E9PCH5_HUMAN | Calpain inhibitor | CAST | 673 | Annotation score: | ||
E9PDE4 | E9PDE4_HUMAN | Calpain inhibitor | CAST | 636 | Annotation score: | ||
A0A0C4DGB5 | A0A0C4DGB5_HUMAN | Calpain inhibitor | CAST | 741 | Annotation score: | ||
F8W7E0 | F8W7E0_HUMAN | Calpain inhibitor | CAST | 393 | Annotation score: | ||
E7ES10 | E7ES10_HUMAN | Calpain inhibitor | CAST | 642 | Annotation score: | ||
E7EVY3 | E7EVY3_HUMAN | Calpain inhibitor | CAST | 693 | Annotation score: | ||
H0YA91 | H0YA91_HUMAN | Calpain inhibitor | CAST | 301 | Annotation score: | ||
B7Z574 | B7Z574_HUMAN | Calpain inhibitor | CAST | 694 | Annotation score: | ||
E7EQ12 | E7EQ12_HUMAN | Calpain inhibitor | CAST | 423 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008906 Genomic DNA No translation available. AC020900 Genomic DNA No translation available. AC104125 Genomic DNA No translation available. KC877037 Genomic DNA No translation available. |
RefSeqi | XP_006714776.1, XM_006714713.3 |
Genome annotation databases
Ensembli | ENST00000515663; ENSP00000422929; ENSG00000153113 |
UCSCi | uc032vds.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008906 Genomic DNA No translation available. AC020900 Genomic DNA No translation available. AC104125 Genomic DNA No translation available. KC877037 Genomic DNA No translation available. |
RefSeqi | XP_006714776.1, XM_006714713.3 |
3D structure databases
SMRi | E7EQA0 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E7EQA0 |
PeptideAtlasi | E7EQA0 |
PRIDEi | E7EQA0 |
ProteomicsDBi | 17531 |
Protocols and materials databases
Antibodypediai | 4008, 410 antibodies from 32 providers |
Genome annotation databases
Ensembli | ENST00000515663; ENSP00000422929; ENSG00000153113 |
UCSCi | uc032vds.2, human |
Organism-specific databases
HGNCi | HGNC:1515, CAST |
OpenTargetsi | ENSG00000153113 |
VEuPathDBi | HostDB:ENSG00000153113 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000002993 |
Miscellaneous databases
BioGRID-ORCSi | 831, 13 hits in 1046 CRISPR screens |
ChiTaRSi | CAST, human |
GenomeRNAii | 831 |
Gene expression databases
Bgeei | ENSG00000153113, Expressed in calcaneal tendon and 251 other tissues |
ExpressionAtlasi | E7EQA0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR026998, Calpastatin IPR001259, Prot_inh_calpain |
PANTHERi | PTHR10077, PTHR10077, 1 hit |
Pfami | View protein in Pfam PF00748, Calpain_inhib, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | E7EQA0_HUMAN | |
Accessioni | E7EQA0Primary (citable) accession number: E7EQA0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | January 19, 2022 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |