CAST

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: CalpastatinImported
Gene namesⁱ	Name:CASTImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000153113.23
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1515 CAST

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000153113

OpenTargetsⁱ

ENSG00000153113

PTM / Processingⁱ

Proteomic databases

EPDⁱ	E7EQA0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E7EQA0
PeptideAtlas More...PeptideAtlasⁱ	E7EQA0
PRIDEⁱ	E7EQA0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000153113
ExpressionAtlasⁱ	E7EQA0 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E7EQA0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	178 – 198	Sequence analysisAdd BLAST		21

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IFF9 Eukaryota ENOG4111YF0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002993

Family and domain databases

InterProⁱ	View protein in InterPro IPR026998 Calpastatin IPR001259 Prot_inh_calpain
PANTHERⁱ	PTHR10077 PTHR10077, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00748 Calpain_inhib, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

E7EQA0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGQFLSSTFL EGSPATVWHD KLCDGERRGA REAVRIFQDQ AKAKEEKLEK 
        60         70         80         90        100
CGEDDETIPS EYRLKPATDK DGKPLLPEPE EKPKPRSESE LIDELSEDFD 
       110        120        130        140        150
RSECKEKPSK PTEKTEESKA AAPAPVSEAV CRTSMCSIQS APPEPATLKG 
       160        170        180        190        200
TVPDDAVEAL ADSLGKKEAD PEDGKPVMDK VKEKAKEEDR EKLGEKEETI 
       210        220        230        240        250
PPDYRLEEVK DKDGKPLLPK ESKEQLPPMS EDFLLDALSE DFSGPQNASS 
       260        270        280        290        300
LKFEDAKLAA AISEVVSQTP ASTTQAGAPP RDTSQSDKDL DDALDKLSDS 
       310        320        330        340        350
LGQRQPDPDE NKPMEDKVKE KAKAEHRDKL GERDDTIPPE YRHLLDDNGQ 
       360        370        380        390        400
DKPVKPPTKK SEDSKKPADD QDPIDALSGD LDSCPSTTET SQNTAKDKCK 
       410        420        430 
KAASSSKAPK NGGKAKDSAK TTEETSKPKD D

Length:431

Mass (Da):47,171

Last modified:March 8, 2011 - v1

Checksum:ⁱE668821E9BFDA2D5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC008906 Genomic DNA No translation available. AC020900 Genomic DNA No translation available. AC104125 Genomic DNA No translation available. KC877037 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_006714776.1, XM_006714713.3
UniGeneⁱ	Hs.436186

Genome annotation databases

Ensemblⁱ	ENST00000515663; ENSP00000422929; ENSG00000153113
UCSC genome browser More...UCSCⁱ	uc032vds.2 human

Protein	Similar proteins		Species	Score	Length
E7EQA0	Calpastatin (Fragment)		HUMAN		465
CAST isoform 4 (Fragment)		PANTR		435
CAST isoform 35 (Fragment)		PONAB		435
Calpastatin (Fragment)		HUMAN		436
Calpastatin (Fragment)		HUMAN		435
+6

Protein	Similar proteins		Species	Score	Length
E7EQA0	UPI000A31A2C9		MUSCR		446
Calpastatin, isoform CRA_a		MOUSE		445
UPI000A312630		MUSPA		445
cDNA FLJ77693, highly similar to Homo sapiens calpastatin (CAST), transcript variant 3, mRNA		HUMAN		431
CAST isoform 35 (Fragment)		PONAB		435
+48

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC008906 Genomic DNA No translation available. AC020900 Genomic DNA No translation available. AC104125 Genomic DNA No translation available. KC877037 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_006714776.1, XM_006714713.3
UniGeneⁱ	Hs.436186

3D structure databases

ProteinModelPortalⁱ	E7EQA0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

EPDⁱ	E7EQA0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E7EQA0
PeptideAtlas More...PeptideAtlasⁱ	E7EQA0
PRIDEⁱ	E7EQA0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000515663; ENSP00000422929; ENSG00000153113
UCSC genome browser More...UCSCⁱ	uc032vds.2 human

Organism-specific databases

CTDⁱ	831
EuPathDBⁱ	HostDB:ENSG00000153113.23
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1515 CAST
Open Targets More...OpenTargetsⁱ	ENSG00000153113
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFF9 Eukaryota ENOG4111YF0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002993

Miscellaneous databases

ChiTaRSⁱ	CAST human
GenomeRNAiⁱ	831

Gene expression databases

Bgeeⁱ	ENSG00000153113
ExpressionAtlasⁱ	E7EQA0 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR026998 Calpastatin IPR001259 Prot_inh_calpain
PANTHERⁱ	PTHR10077 PTHR10077, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00748 Calpain_inhib, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E7EQA0_HUMAN
Accessionⁱ	E7EQA0Primary (citable) accession number: E7EQA0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 8, 2011
	Last sequence update:	March 8, 2011
	Last modified:	June 20, 2018
	This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - E7EQA0 (E7EQA0_HUMAN)

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Calpastatin

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Names & Taxonomyⁱ

Organism-specific databases

Pathology & Biotechⁱ

Organism-specific databases

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

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UniRef

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Supporting data

UniProtKB - E7EQA0 (E7EQA0_HUMAN)

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Calpastatin

CAST

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ