UniProtKB - E7EQ52 (E7EQ52_HUMAN)
Protein
Poly [ADP-ribose] polymerase
Gene
TNKS
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- NAD+ ADP-ribosyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- positive regulation of telomere maintenance via telomerase Source: InterPro
- spindle assembly Source: InterPro
- Wnt signaling pathway Source: InterPro
Keywordsi
Molecular function | GlycosyltransferaseUniRule annotation, Transferase |
Ligand | NADUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.-UniRule annotation)Short name: PARPUniRule annotation |
Gene namesi | Name:TNKSImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11941, TNKS |
VEuPathDBi | HostDB:ENSG00000173273.15 |
PTM / Processingi
Proteomic databases
MaxQBi | E7EQ52 |
PeptideAtlasi | E7EQ52 |
PRIDEi | E7EQ52 |
ProteomicsDBi | 17505 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173273, Expressed in forebrain and 242 other tissues |
ExpressionAtlasi | E7EQ52, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 706 | ANK_REP_REGIONInterPro annotationAdd BLAST | 706 | |
Repeati | 11 – 43 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 44 – 76 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 131 – 163 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 164 – 196 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 197 – 229 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 284 – 319 | ANKPROSITE-ProRule annotationAdd BLAST | 36 | |
Repeati | 320 – 352 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 353 – 385 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 446 – 478 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 479 – 511 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 512 – 544 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 599 – 631 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 632 – 664 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 665 – 697 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 793 – 852 | SAMInterPro annotationAdd BLAST | 60 | |
Domaini | 875 – 1080 | PARP catalyticInterPro annotationAdd BLAST | 206 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationARBA annotation, RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156161 |
HOGENOMi | CLU_004303_0_0_1 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 1.25.40.20, 5 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR012317, Poly(ADP-ribose)pol_cat_dom IPR001660, SAM IPR013761, SAM/pointed_sf IPR028731, TANK1 |
PANTHERi | PTHR24180:SF3, PTHR24180:SF3, 3 hits |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 3 hits PF00644, PARP, 1 hit PF07647, SAM_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 16 hits SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF48403, SSF48403, 3 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 14 hits PS51059, PARP_CATALYTIC, 1 hit PS50105, SAM_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
E7EQ52-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGANVHARDD GGLIPLHNAC SFGHAEVVSL LLCQGADPNA RDNWNYTPLH
60 70 80 90 100
EAAIKGKIDV CIVLLQHGAD PNIRNTDGKS ALDLADPSAK AVLTGEYKKD
110 120 130 140 150
ELLEAARSGN EEKLMALLTP LNVNCHASDG RKSTPLHLAA GYNRVRIVQL
160 170 180 190 200
LLQHGADVHA KDKGGLVPLH NACSYGHYEV TELLLKHGAC VNAMDLWQFT
210 220 230 240 250
PLHEAASKNR VEVCSLLLSH GADPTLVNCH GKSAVDMAPT PELRERLTYE
260 270 280 290 300
FKGHSLLQAA READLAKVKK TLALEIINFK QPQSHETALH CAVASLHPKR
310 320 330 340 350
KQVTELLLRK GANVNEKNKD FMTPLHVAAE RAHNDVMEVL HKHGAKMNAL
360 370 380 390 400
DTLGQTALHR AALAGHLQTC RLLLSYGSDP SIISLQGFTA AQMGNEAVQQ
410 420 430 440 450
ILSESTPIRT SDVDYRLLEA SKAGDLETVK QLCSSQNVNC RDLEGRHSTP
460 470 480 490 500
LHFAAGYNRV SVVEYLLHHG ADVHAKDKGG LVPLHNACSY GHYEVAELLV
510 520 530 540 550
RHGASVNVAD LWKFTPLHEA AAKGKYEICK LLLKHGADPT KKNRDGNTPL
560 570 580 590 600
DLVKEGDTDI QDLLRGDAAL LDAAKKGCLA RVQKLCTPEN INCRDTQGRN
610 620 630 640 650
STPLHLAAGY NNLEVAEYLL EHGADVNAQD KGGLIPLHNA ASYGHVDIAA
660 670 680 690 700
LLIKYNTCVN ATDKWAFTPL HEAAQKGRTQ LCALLLAHGA DPTMKNQEGQ
710 720 730 740 750
TPLDLATADD IRALLIDAMP PEALPTCFKP QATVVSASLI SPASTPSCLS
760 770 780 790 800
AASSIDNLTG PLAELAVGGA SNAGDGAAGT ERKEGEVAGL DMNISQFLKS
810 820 830 840 850
LGLEHLRDIF ETEQITLDVL ADMGHEELKE IGINAYGHRH KLIKGVERLL
860 870 880 890 900
GGQQGTNPYL TFHCVNQGTI LLDLAPEDKE YQSVEEEMQS TIREHRDGGN
910 920 930 940 950
AGGIFNRYNV IRIQKVVNKK LRERFCHRQK EVSEENHNHH NERMLFHGSP
960 970 980 990 1000
FINAIIHKGF DERHAYIGGM FGAGIYFAEN SSKSNQYVYG IGGGTGCPTH
1010 1020 1030 1040 1050
KDRSCYICHR QMLFCRVTLG KSFLQFSTMK MAHAPPGHHS VIGRPSVNGL
1060 1070 1080 1090
AYAEYVIYRG EQAYPEYLIT YQIMKPEAPS QTATAAEQKT
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO95271 | TNKS1_HUMAN | Poly [ADP-ribose] polymerase tankyr... | TNKS PARP5A, PARPL, TIN1, TINF1, TNKS1 | 1,327 | Annotation score: | ||
E7EWY6 | E7EWY6_HUMAN | Poly [ADP-ribose] polymerase tankyr... | TNKS | 617 | Annotation score: | ||
E5RHD2 | E5RHD2_HUMAN | Poly [ADP-ribose] polymerase tankyr... | TNKS | 243 | Annotation score: | ||
H0YAW5 | H0YAW5_HUMAN | Poly [ADP-ribose] polymerase tankyr... | TNKS | 61 | Annotation score: | ||
A0A0C4DGE3 | A0A0C4DGE3_HUMAN | Poly [ADP-ribose] polymerase tankyr... | TNKS | 68 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021242 Genomic DNA No translation available. AC103834 Genomic DNA No translation available. AC103877 Genomic DNA No translation available. AC104052 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000518281; ENSP00000429890; ENSG00000173273 |
UCSCi | uc011kww.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021242 Genomic DNA No translation available. AC103834 Genomic DNA No translation available. AC103877 Genomic DNA No translation available. AC104052 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | E7EQ52, 1 interactor |
Proteomic databases
MaxQBi | E7EQ52 |
PeptideAtlasi | E7EQ52 |
PRIDEi | E7EQ52 |
ProteomicsDBi | 17505 |
Protocols and materials databases
Antibodypediai | 22078, 360 antibodies |
Genome annotation databases
Ensembli | ENST00000518281; ENSP00000429890; ENSG00000173273 |
UCSCi | uc011kww.3, human |
Organism-specific databases
HGNCi | HGNC:11941, TNKS |
OpenTargetsi | ENSG00000173273 |
VEuPathDBi | HostDB:ENSG00000173273.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156161 |
HOGENOMi | CLU_004303_0_0_1 |
Miscellaneous databases
ChiTaRSi | TNKS, human |
Gene expression databases
Bgeei | ENSG00000173273, Expressed in forebrain and 242 other tissues |
ExpressionAtlasi | E7EQ52, baseline and differential |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 1.25.40.20, 5 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR012317, Poly(ADP-ribose)pol_cat_dom IPR001660, SAM IPR013761, SAM/pointed_sf IPR028731, TANK1 |
PANTHERi | PTHR24180:SF3, PTHR24180:SF3, 3 hits |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 3 hits PF00644, PARP, 1 hit PF07647, SAM_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 16 hits SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF48403, SSF48403, 3 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 14 hits PS51059, PARP_CATALYTIC, 1 hit PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7EQ52_HUMAN | |
Accessioni | E7EQ52Primary (citable) accession number: E7EQ52 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | February 10, 2021 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |