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Protein
Submitted name:

Caspase-8

Gene

CASP8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase-8Imported
Gene namesi
Name:CASP8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000064012.21
HGNCiHGNC:1509 CASP8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000064012

PTM / Processingi

Proteomic databases

MaxQBiE7EQ06
PeptideAtlasiE7EQ06
PRIDEiE7EQ06

Expressioni

Gene expression databases

BgeeiENSG00000064012 Expressed in 196 organ(s), highest expression level in small intestine Peyer's patch
ExpressionAtlasiE7EQ06 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE7EQ06
SMRiE7EQ06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 80DEDInterPro annotationAdd BLAST79
Domaini100 – 177DEDInterPro annotationAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili69 – 89Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00760000118912

Family and domain databases

InterProiView protein in InterPro
IPR033170 Caspase-8
IPR011029 DEATH-like_dom_sf
IPR001875 DED_dom
PANTHERiPTHR10454:SF162 PTHR10454:SF162, 1 hit
PfamiView protein in Pfam
PF01335 DED, 2 hits
SMARTiView protein in SMART
SM00031 DED, 2 hits
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50168 DED, 2 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.iShow all

E7EQ06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFSRNLYDI GEQLDSEDLA SLKFLSLDYI PQRKQEPIKD ALMLFQRLQE
60 70 80 90 100
KRMLEESNLS FLKELLFRIN RLDLLITYLN TRKEEMEREL QTPGRAQISA
110 120 130 140 150
YRVMLYQISE EVSRSELRSF KFLLQEEISK CKLDDDMNLL DIFIEMEKRV
160 170 180 190 200
ILGEGKLDIL KRVCAQINKS LLKIINDYEE FSKDFGQSLP NEKQTSGILS

DHQQSQFCK
Length:209
Mass (Da):24,748
Last modified:March 8, 2011 - v1
Checksum:iA205EBFDEA07256F
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q14790CASP8_HUMAN
Caspase-8
CASP8 MCH5
479Annotation score:
H7C0E2H7C0E2_HUMAN
Caspase-8
CASP8
258Annotation score:
E7ETB7E7ETB7_HUMAN
Caspase-8
CASP8
198Annotation score:
E7EVN1E7EVN1_HUMAN
Caspase-8
CASP8
124Annotation score:
E7EQ01E7EQ01_HUMAN
Caspase-8
CASP8
116Annotation score:
A0A0A0MS31A0A0A0MS31_HUMAN
Caspase-8
CASP8
278Annotation score:
C9JB29C9JB29_HUMAN
Caspase-8
CASP8
149Annotation score:
F8WF39F8WF39_HUMAN
Caspase-8
CASP8
58Annotation score:
H7BZM4H7BZM4_HUMAN
Caspase-8
CASP8
83Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei209Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007256 Genomic DNA No translation available.
AC007283 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000447616; ENSP00000388306; ENSG00000064012
UCSCiuc061rjv.1 human

Similar proteinsi

Entry informationi

Entry nameiE7EQ06_HUMAN
AccessioniPrimary (citable) accession number: E7EQ06
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 12, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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