UniProtKB - E7EPU1 (E7EPU1_HUMAN)
Protein
Submitted name:
Urea transporter 2
Gene
SLC14A2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Urea transporter 2Imported |
Gene namesi | Name:SLC14A2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10919, SLC14A2 |
VEuPathDBi | HostDB:ENSG00000132874.13 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 121 – 145 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 151 – 170 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000132874, Expressed in kidney and 72 other tissues |
ExpressionAtlasi | E7EPU1, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 57 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 43 – 57 | PolyampholyteSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the urea transporter family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000018729 |
HOGENOMi | CLU_102985_0_0_1 |
Family and domain databases
Gene3Di | 1.10.3430.10, 1 hit |
InterProi | View protein in InterPro IPR029020, Ammonium/urea_transptr IPR004937, Urea_transporter |
PANTHERi | PTHR10464, PTHR10464, 2 hits |
Pfami | View protein in Pfam PF03253, UT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
E7EPU1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDPHSSPLL PEPLSSRYKL YEAEFTSPSW PSTSPDTHPA LPLLEMPEEK
60 70 80 90 100
DLRSSNEDSH IVKIEKLNER SKRKDDGVAH RDSAGQRCIC LSKAVGYLTG
110 120 130 140 150
DMKEYRIWLK DKHLALQFID WVLRGTAQVM FINNPLSGLI IFIGLLIQNP
160 170 180 190 200
WWTITGGLGT VVSTLTALAL GQDRSAIASG LHGYNGMLVG LLMAVFSEKL
210 220 230
DYYWWLLFPV TFTAMSWMET DFNWSKSGCW KHLLQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ15849 | UT2_HUMAN | Urea transporter 2 | SLC14A2 HUT2, UT2 | 920 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021517 Genomic DNA No translation available. AC021810 Genomic DNA No translation available. AC023421 Genomic DNA No translation available. AC090376 Genomic DNA No translation available. AC091151 Genomic DNA No translation available. KF456392 Genomic DNA No translation available. KF456398 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000323329; ENSP00000320689; ENSG00000132874 |
UCSCi | uc060oss.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021517 Genomic DNA No translation available. AC021810 Genomic DNA No translation available. AC023421 Genomic DNA No translation available. AC090376 Genomic DNA No translation available. AC091151 Genomic DNA No translation available. KF456392 Genomic DNA No translation available. KF456398 Genomic DNA No translation available. |
3D structure databases
SMRi | E7EPU1 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | E7EPU1 |
PRIDEi | E7EPU1 |
ProteomicsDBi | 17442 |
Genome annotation databases
Ensembli | ENST00000323329; ENSP00000320689; ENSG00000132874 |
UCSCi | uc060oss.1, human |
Organism-specific databases
HGNCi | HGNC:10919, SLC14A2 |
OpenTargetsi | ENSG00000132874 |
VEuPathDBi | HostDB:ENSG00000132874.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000018729 |
HOGENOMi | CLU_102985_0_0_1 |
Miscellaneous databases
ChiTaRSi | SLC14A2, human |
Gene expression databases
Bgeei | ENSG00000132874, Expressed in kidney and 72 other tissues |
ExpressionAtlasi | E7EPU1, baseline and differential |
Family and domain databases
Gene3Di | 1.10.3430.10, 1 hit |
InterProi | View protein in InterPro IPR029020, Ammonium/urea_transptr IPR004937, Urea_transporter |
PANTHERi | PTHR10464, PTHR10464, 2 hits |
Pfami | View protein in Pfam PF03253, UT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7EPU1_HUMAN | |
Accessioni | E7EPU1Primary (citable) accession number: E7EPU1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | February 10, 2021 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |