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Entry version 79 (12 Aug 2020)
Sequence version 2 (03 Apr 2013)
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Protein
Submitted name:

Triple functional domain protein

Gene

TRIO

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseARBA annotation, Transferase
LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Triple functional domain proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIOImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000038382.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12303, TRIO

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000038382

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E7EPJ7

PeptideAtlas

More...
PeptideAtlasi
E7EPJ7

PRoteomics IDEntifications database

More...
PRIDEi
E7EPJ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
17374

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000038382, Expressed in stomach and 232 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7EPJ7, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E7EPJ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1025 – 1200DHInterPro annotationAdd BLAST176
Domaini1212 – 1324PHInterPro annotationAdd BLAST113
Domaini1389 – 1454SH3InterPro annotationAdd BLAST66
Domaini1702 – 1878DHInterPro annotationAdd BLAST177
Domaini1890 – 2004PHInterPro annotationAdd BLAST115
Domaini2284 – 2349SH3InterPro annotationAdd BLAST66
Domaini2418 – 2508Ig-likeInterPro annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1334 – 1383DisorderedSequence analysisAdd BLAST50
Regioni1512 – 1639DisorderedSequence analysisAdd BLAST128
Regioni1660 – 1698DisorderedSequence analysisAdd BLAST39
Regioni2020 – 2285DisorderedSequence analysisAdd BLAST266
Regioni2372 – 2393DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili490 – 517Sequence analysisAdd BLAST28
Coiled coili618 – 638Sequence analysisAdd BLAST21
Coiled coili676 – 696Sequence analysisAdd BLAST21
Coiled coili908 – 928Sequence analysisAdd BLAST21
Coiled coili1639 – 1659Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1361 – 1383PolarSequence analysisAdd BLAST23
Compositional biasi1539 – 1568PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1569 – 1588PolarSequence analysisAdd BLAST20
Compositional biasi1611 – 1639PolarSequence analysisAdd BLAST29
Compositional biasi1664 – 1688PolarSequence analysisAdd BLAST25
Compositional biasi2052 – 2073PolarSequence analysisAdd BLAST22
Compositional biasi2086 – 2104PolarSequence analysisAdd BLAST19
Compositional biasi2105 – 2123Pro-richSequence analysisAdd BLAST19
Compositional biasi2130 – 2147PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2213 – 2246PolarSequence analysisAdd BLAST34
Compositional biasi2257 – 2285PolarSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154766

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000373_1_0_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160, RhoGEF, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR028570, TRIO

The PANTHER Classification System

More...
PANTHERi
PTHR22826:SF104, PTHR22826:SF104, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679, I-set, 1 hit
PF00169, PH, 2 hits
PF00621, RhoGEF, 2 hits
PF00018, SH3_1, 1 hit
PF00435, Spectrin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00233, PH, 2 hits
SM00325, RhoGEF, 2 hits
SM00326, SH3, 2 hits
SM00150, SPEC, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 2 hits
SSF48726, SSF48726, 1 hit
SSF50044, SSF50044, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 2 hits
PS50835, IG_LIKE, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS50002, SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E7EPJ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
IKAPIEDLDL EGQKLLQRIQ SSESFPKKNS GSGNADLQNL LPKVSTMLDR
60 70 80 90 100
LHSTRQHLHQ MWHVRKLKLD QCFQLRLFEQ DAEKMFDWIT HNKGLFLNSY
110 120 130 140 150
TEIGTSHPHA MELQTQHNHF AMNCMNVYVN INRIMSVANR LVESGHYASQ
160 170 180 190 200
QIRQIASQLE QEWKAFAAAL DERSTLLDMS SIFHQKAEKY MSNVDSWCKA
210 220 230 240 250
CGEVDLPSEL QDLEDAIHHH QGIYEHITLA YSEVSQDGKS LLDKLQRPLT
260 270 280 290 300
PGSSDSLTAS ANYSKAVHHV LDVIHEVLHH QRQLENIWQH RKVRLHQRLQ
310 320 330 340 350
LCVFQQDVQQ VLDWIENHGE AFLSKHTGVG KSLHRARALQ KRHEDFEEVA
360 370 380 390 400
QNTYTNADKL LEAAEQLAQT GECDPEEIYQ AAHQLEDRIQ DFVRRVEQRK
410 420 430 440 450
ILLDMSVSFH THVKELWTWL EELQKELLDD VYAESVEAVQ DLIKRFGQQQ
460 470 480 490 500
QTTLQVTVNV IKEGEDLIQQ LRDSAISSNK TPHNSSINHI ETVLQQLDEA
510 520 530 540 550
QSQMEELFQE RKIKLELFLQ LRIFERDAID IISDLESWND ELSQQMNDFD
560 570 580 590 600
TEDLTIAEQR LQHHADKALT MNNLTFDVIH QGQDLLQYVN EVQASGVELL
610 620 630 640 650
CDRDVDMATR VQDLLEFLHE KQQELDLAAE QHRKHLEQCV QLRHLQAEVK
660 670 680 690 700
QVLGWIRNGE SMLNAGLITA SSLQEAEQLQ REHEQFQHAI EKTHQSALQV
710 720 730 740 750
QQKAEAMLQA NHYDMDMIRD CAEKVASHWQ QLMLKMEDRL KLVNASVAFY
760 770 780 790 800
KTSEQVCSVL ESLEQEYKRE EDWCGGADKL GPNSETDHVT PMISKHLEQK
810 820 830 840 850
EAFLKACTLA RRNADVFLKY LHRNSVNMPG MVTHIKAPEQ QVKNILNELF
860 870 880 890 900
QRENRVLHYW TMRKRRLDQC QQYVVFERSA KQALEWIHDN GEFYLSTHTS
910 920 930 940 950
TGSSIQHTQE LLKEHEEFQI TAKQTKERVK LLIQLADGFC EKGHAHAAEI
960 970 980 990 1000
KKCVTAVDKR YRDFSLRMEK YRTSLEKALG ISSDSNKSSK SLQLDIIPAS
1010 1020 1030 1040 1050
IPGSEVKLRD AAHELNEEKR KSARRKEFIM AELIQTEKAY VRDLRECMDT
1060 1070 1080 1090 1100
YLWEMTSGVE EIPPGIVNKE LIIFGNMQEI YEFHNNIFLK ELEKYEQLPE
1110 1120 1130 1140 1150
DVGHCFVTWA DKFQMYVTYC KNKPDSTQLI LEHAGSYFDE IQQRHGLANS
1160 1170 1180 1190 1200
ISSYLIKPVQ RITKYQLLLK ELLTCCEEGK GEIKDGLEVM LSVPKRANDA
1210 1220 1230 1240 1250
MHLSMLEGFD ENIESQGELI LQESFQVWDP KTLIRKGRER HLFLFEMSLV
1260 1270 1280 1290 1300
FSKEVKDSSG RSKYLYKSKL FTSELGVTEH VEGDPCKFAL WVGRTPTSDN
1310 1320 1330 1340 1350
KIVLKASSIE NKQDWIKHIR EVIQERTIHL KGALKEPIHI PKTAPATRQK
1360 1370 1380 1390 1400
GRRDGEDLDS QGDGSSQPDT ISIASRTSQN TLDSDKLSGG CELTVVIHDF
1410 1420 1430 1440 1450
TACNSNELTI RRGQTVEVLE RPHDKPDWCL VRTTDRSPAA EGLVPCGSLC
1460 1470 1480 1490 1500
IAHSRSSMEM EGIFNHKDSL SVSSNDASPP ASVASLQPHM IGAQSSPGPK
1510 1520 1530 1540 1550
RPGNTLRKWL TSPVRRLSSG KADGHVKKLA HKHKKSREVR KSADAGSQKD
1560 1570 1580 1590 1600
SDDSAATPQD ETVEERGRNE GLSSGTLSKS SSSGMQSCGE EEGEEGADAV
1610 1620 1630 1640 1650
PLPPPMAIQQ HSLLQPDSQD DKASSRLLVR PTSSETPSAA ELVSAIEELV
1660 1670 1680 1690 1700
KSKMALEDRP SSLLVDQGDS SSPSFNPSDN SLLSSSSPID EMEERKSSSL
1710 1720 1730 1740 1750
KRRHYVLQEL VETERDYVRD LGYVVEGYMA LMKEDGVPDD MKGKDKIVFG
1760 1770 1780 1790 1800
NIHQIYDWHR DFFLGELEKC LEDPEKLGSL FVKHERRLHM YIAYCQNKPK
1810 1820 1830 1840 1850
SEHIVSEYID TFFEDLKQRL GHRLQLTDLL IKPVQRIMKY QLLLKDFLKY
1860 1870 1880 1890 1900
SKKASLDTSE LERAVEVMCI VPRRCNDMMN VGRLQGFDGK IVAQGKLLLQ
1910 1920 1930 1940 1950
DTFLVTDQDA GLLPRCRERR IFLFEQIVIF SEPLDKKKGF SMPGFLFKNS
1960 1970 1980 1990 2000
IKVSCLCLEE NVENDPCKFA LTSRTGDVVE TFILHSSSPS VRQTWIHEIN
2010 2020 2030 2040 2050
QILENQRNFL NALTSPIEYQ RNHSGGGGGG GSGGSGGGGG SGGGGAPSGG
2060 2070 2080 2090 2100
SGHSGGPSSC GGAPSTSRSR PSRIPQPVRH HPPVLVSSAA SSQAEADKMS
2110 2120 2130 2140 2150
GTSTPGPSLP PPGAAPEAGP SAPSRRPPGA DAEGSEREAE PIPKMKVLES
2160 2170 2180 2190 2200
PRKGAANASG SSPDAPAKDA RASLGTLPLG KPRAGAASPL NSPLSSAVPS
2210 2220 2230 2240 2250
LGKEPFPPSS PLQKGGSFWS SIPASPASRP GSFTFPGDSD SLQRQTPRHA
2260 2270 2280 2290 2300
APGKDTDRMS TCSSASEQSV QSTQSNGSES SSSSNISTML VTHDYTAVKE
2310 2320 2330 2340 2350
DEINVYQGEV VQILASNQQN MFLVFRAATD QCPAAEGWIP GFVLGHTSAV
2360 2370 2380 2390 2400
IVENPDGTLK KSTSWHTALR LRKKSEKKDK DGKREGKLEN GYRKSREGLS
2410 2420 2430 2440 2450
NKVSVKLLNP NYIYDVPPEF VIPLSEVTCE TGETVVLRCR VCGRPKASIT
2460 2470 2480 2490 2500
WKGPEHNTLN NDGHYSISYS DLGEATLKIV GVTTEDDGIY TCIAVNDMGS
2510 2520 2530 2540
ASSSASLRVL GPGMDGIMVT WKDNFDSFYS EVAELGRANW NNWSPY
Length:2,546
Mass (Da):285,812
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38FC0B0F3E91BEA6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O75962TRIO_HUMAN
Triple functional domain protein
TRIO
3,097Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWP2E7EWP2_HUMAN
Triple functional domain protein
TRIO
2,309Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRD7A0A1W2PRD7_HUMAN
Triple functional domain protein
TRIO
458Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X139A0A087X139_HUMAN
Triple functional domain protein
TRIO
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H228F5H228_HUMAN
Triple functional domain protein
TRIO
1,508Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010419 Genomic DNA No translation available.
AC016549 Genomic DNA No translation available.
AC016654 Genomic DNA No translation available.
AC016656 Genomic DNA No translation available.
AC026456 Genomic DNA No translation available.
KC876940 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000513206; ENSP00000426342; ENSG00000038382

UCSC genome browser

More...
UCSCi
uc063cko.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010419 Genomic DNA No translation available.
AC016549 Genomic DNA No translation available.
AC016654 Genomic DNA No translation available.
AC016656 Genomic DNA No translation available.
AC026456 Genomic DNA No translation available.
KC876940 Genomic DNA No translation available.

3D structure databases

SMRiE7EPJ7
ModBaseiSearch...

Proteomic databases

MaxQBiE7EPJ7
PeptideAtlasiE7EPJ7
PRIDEiE7EPJ7
ProteomicsDBi17374

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2116, 53 antibodies

Genome annotation databases

EnsembliENST00000513206; ENSP00000426342; ENSG00000038382
UCSCiuc063cko.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000038382.17
HGNCiHGNC:12303, TRIO
OpenTargetsiENSG00000038382

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00940000154766
HOGENOMiCLU_000373_1_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRIO, human

Gene expression databases

BgeeiENSG00000038382, Expressed in stomach and 232 other tissues
ExpressionAtlasiE7EPJ7, baseline and differential

Family and domain databases

CDDicd00160, RhoGEF, 2 hits
Gene3Di1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR028570, TRIO
PANTHERiPTHR22826:SF104, PTHR22826:SF104, 3 hits
PfamiView protein in Pfam
PF07679, I-set, 1 hit
PF00169, PH, 2 hits
PF00621, RhoGEF, 2 hits
PF00018, SH3_1, 1 hit
PF00435, Spectrin, 4 hits
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00233, PH, 2 hits
SM00325, RhoGEF, 2 hits
SM00326, SH3, 2 hits
SM00150, SPEC, 5 hits
SUPFAMiSSF48065, SSF48065, 2 hits
SSF48726, SSF48726, 1 hit
SSF50044, SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS50010, DH_2, 2 hits
PS50835, IG_LIKE, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS50002, SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7EPJ7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7EPJ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: April 3, 2013
Last modified: August 12, 2020
This is version 79 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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