UniProtKB - E7EPC8 (E7EPC8_HUMAN)
Protein
Submitted name:
Catenin delta-2
Gene
CTNND2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- cell-cell adhesion Source: InterPro
Keywordsi
Biological process | Cell adhesionARBA annotation |
Enzyme and pathway databases
SignaLinki | E7EPC8 |
Names & Taxonomyi
Protein namesi | Submitted name: Catenin delta-2Imported |
Gene namesi | Name:CTNND2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169862.18 |
HGNCi | HGNC:2516, CTNND2 |
Subcellular locationi
Other locations
- cell junction Source: UniProtKB-KW
Keywords - Cellular componenti
Cell junctionARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | E7EPC8 |
PeptideAtlasi | E7EPC8 |
PRIDEi | E7EPC8 |
ProteomicsDBi | 17330 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169862, Expressed in cortical plate and 171 other tissues |
ExpressionAtlasi | E7EPC8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 501 – 534 | ARMPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 545 – 588 | ARMPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 801 – 838 | ARMPROSITE-ProRule annotationAdd BLAST | 38 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 43 – 151 | DisorderedSequence analysisAdd BLAST | 109 | |
Regioni | 165 – 221 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 341 – 392 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 426 – 450 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 951 – 988 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 54 – 119 | PolarSequence analysisAdd BLAST | 66 | |
Compositional biasi | 124 – 140 | Pro-richSequence analysisAdd BLAST | 17 | |
Compositional biasi | 205 – 221 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 342 – 392 | PolarSequence analysisAdd BLAST | 51 | |
Compositional biasi | 951 – 984 | PolarSequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the beta-catenin family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000154952 |
OrthoDBi | 233858at2759 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR028435, Plakophilin/d_Catenin |
PANTHERi | PTHR10372, PTHR10372, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 4 hits |
SMARTi | View protein in SMART SM00185, ARM, 7 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
E7EPC8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSMSSAEEQ FQWQSQDGQK DIEDELTTGL ELVDSCIRSL QESGILDPQD
60 70 80 90 100
YSTGERPSLL SQSALQLNSK PEGSFQYPAS YHSNQTLALG ETTPSQLPAR
110 120 130 140 150
GTQARATGQS FSQGTTSRAG HLAGPEPAPP PPPPPREPFA PSLGSAFHLP
160 170 180 190 200
DAPPAAAAAA LYYSSSTLPA PPRGGSPLAA PQGGSPTKLQ RGGSAPEGAT
210 220 230 240 250
YAAPRGSSPK QSPSRLAKSY STSSPINIVV SSAGLSPIRV TSPPTVQSTI
260 270 280 290 300
SSSPIHQLSS TIGTYATLSP TKRLVHASEQ YSKHSQELYA TATLQRPGSL
310 320 330 340 350
AAGSRASYSS QHGHLGPELR ALQSPEHHID PIYEDRVYQK PPMRSLSQSQ
360 370 380 390 400
GDPLPPAHTG TYRTSTAPSS PGVDSVPLQR TGSQHGPQNA AAATFQRASY
410 420 430 440 450
AAGPASNYAD PYRQLQYCPS VESPYSKSGP ALPPEGTLAR SPSIDSIQKD
460 470 480 490 500
PREFGWRDPE LPEVIQMLQH QFPSVQSNAA AYLQHLCFGD NKIKAEIRRQ
510 520 530 540 550
GGIQLLVDLL DHRMTEVHRS ACGALRNLVY GKANDDNKIA LKNCGGIPAL
560 570 580 590 600
VRLLRKTTDL EIRELVTGVL WNLSSCDALK MPIIQDALAV LTNAVIIPHS
610 620 630 640 650
GWENSPLQDD RKIQLHSSQV LRNATGCLRN VSSAGEEARR RMRECDGLTD
660 670 680 690 700
ALLYVIQSAL GSSEIDSKTV ENCVCILRNL SYRLAAETSQ GQHMGTDELD
710 720 730 740 750
GLLCGEANGK DAESSGCWGK KKKKKKSQDQ WDGVGPLPDC AEPPKGIQML
760 770 780 790 800
WHPSIVKPYL TLLSECSNPD TLEGAAGALQ NLAAGSWKWS VYIRAAVRKE
810 820 830 840 850
KGLPILVELL RIDNDRVVCA VATALRNMAL DVRNKELIGK YAMRDLVHRL
860 870 880 890 900
PGGNNSNNTA SKAMSDDTVT AVCCTLHEVI TKNMENAKAL RDAGGIEKLV
910 920 930 940 950
GISKSKGDKH SPKVVKAASQ VLNSMWQYRD LRSLYKKDGW SQYHFVASSS
960 970 980 990 1000
TIERDRQRPY SSSRTPSISP VRVSPNNRSA SAPASPREMI SLKERKTDYE
1010 1020 1030 1040 1050
CTGSNATYHG AKGEHTSRKD AMTAQNTGIS TLYRNSYGAP AEDIKHNQVS
1060 1070 1080 1090 1100
AQPVPQEPSR KDYETYQPFQ NSTRNYDESF FEDQVHHRPP ASEYTMHLGL
1110 1120 1130
KSTGNYVDFY SAARPYSELN YETSHYPASP DSWV
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UQB3 | CTND2_HUMAN | Catenin delta-2 | CTNND2 NPRAP | 1,225 | Annotation score: | ||
E9PHB5 | E9PHB5_HUMAN | Catenin delta-2 | CTNND2 | 912 | Annotation score: | ||
B4DRK2 | B4DRK2_HUMAN | Catenin delta-2 | CTNND2 | 888 | Annotation score: | ||
D6R9A8 | D6R9A8_HUMAN | Catenin delta-2 | CTNND2 | 320 | Annotation score: | ||
D6RBA8 | D6RBA8_HUMAN | Catenin delta-2 | CTNND2 | 169 | Annotation score: | ||
D6RC65 | D6RC65_HUMAN | Catenin delta-2 | CTNND2 | 209 | Annotation score: | ||
D6RHE9 | D6RHE9_HUMAN | Catenin delta-2 | CTNND2 | 231 | Annotation score: | ||
D6RF55 | D6RF55_HUMAN | Catenin delta-2 | CTNND2 | 181 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC003954 Genomic DNA No translation available. AC004648 Genomic DNA No translation available. AC005367 Genomic DNA No translation available. AC005610 Genomic DNA No translation available. AC010626 Genomic DNA No translation available. KC876929 Genomic DNA No translation available. KC876931 Genomic DNA No translation available. KF457862 Genomic DNA No translation available. |
RefSeqi | NP_001275644.1, NM_001288715.1 |
Genome annotation databases
Ensembli | ENST00000511377; ENSP00000426510; ENSG00000169862 |
GeneIDi | 1501 |
UCSCi | uc010itt.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC003954 Genomic DNA No translation available. AC004648 Genomic DNA No translation available. AC005367 Genomic DNA No translation available. AC005610 Genomic DNA No translation available. AC010626 Genomic DNA No translation available. KC876929 Genomic DNA No translation available. KC876931 Genomic DNA No translation available. KF457862 Genomic DNA No translation available. |
RefSeqi | NP_001275644.1, NM_001288715.1 |
3D structure databases
SMRi | E7EPC8 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E7EPC8 |
PeptideAtlasi | E7EPC8 |
PRIDEi | E7EPC8 |
ProteomicsDBi | 17330 |
Protocols and materials databases
Antibodypediai | 9404, 188 antibodies |
Genome annotation databases
Ensembli | ENST00000511377; ENSP00000426510; ENSG00000169862 |
GeneIDi | 1501 |
UCSCi | uc010itt.4, human |
Organism-specific databases
CTDi | 1501 |
EuPathDBi | HostDB:ENSG00000169862.18 |
HGNCi | HGNC:2516, CTNND2 |
OpenTargetsi | ENSG00000169862 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154952 |
OrthoDBi | 233858at2759 |
Enzyme and pathway databases
SignaLinki | E7EPC8 |
Miscellaneous databases
BioGRID-ORCSi | 1501, 2 hits in 845 CRISPR screens |
ChiTaRSi | CTNND2, human |
GenomeRNAii | 1501 |
Gene expression databases
Bgeei | ENSG00000169862, Expressed in cortical plate and 171 other tissues |
ExpressionAtlasi | E7EPC8, baseline and differential |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR028435, Plakophilin/d_Catenin |
PANTHERi | PTHR10372, PTHR10372, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 4 hits |
SMARTi | View protein in SMART SM00185, ARM, 7 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7EPC8_HUMAN | |
Accessioni | E7EPC8Primary (citable) accession number: E7EPC8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |