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Protein
Submitted name:

Sodium-dependent multivitamin transporter

Gene

SLC5A6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium-dependent multivitamin transporterImported
Gene namesi
Name:SLC5A6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138074.14
HGNCiHGNC:11041 SLC5A6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 47HelicalSequence analysisAdd BLAST22
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei100 – 122HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138074

PTM / Processingi

Proteomic databases

MaxQBiE7ENG0
PeptideAtlasiE7ENG0

Expressioni

Gene expression databases

BgeeiENSG00000138074 Expressed in 182 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiE7ENG0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE7ENG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2349 Eukaryota
COG0591 LUCA
GeneTreeiENSGT00760000118955

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
PfamiView protein in Pfam
PF00474 SSF, 1 hit
PROSITEiView protein in PROSITE
PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

E7ENG0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVGVSTSAP LSPTSGTSVG MSTFSIMDYV VFVLLLVLSL AIGLYHACRG
60 70 80 90 100
WGRHTVGELL MADRKMGCLP VALSLLATFQ SAVAILGVPS EIYRFGTQYW
110 120 130
FLGCCYFLGL LIPAHIFIPV FYRLHLTSAY EYL
Length:133
Mass (Da):14,550
Last modified:March 8, 2011 - v1
Checksum:i9C4B441F79DC379C
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Y289SC5A6_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6 SMVT
635Annotation score:
E7EW78E7EW78_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
147Annotation score:
E7ENN0E7ENN0_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
153Annotation score:
E7EMX0E7EMX0_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
193Annotation score:
E7ERE1E7ERE1_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
115Annotation score:
E7EW41E7EW41_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
78Annotation score:
E7EXC0E7EXC0_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
38Annotation score:
E7EP02E7EP02_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
58Annotation score:
Q9HD19Q9HD19_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6 SMVT
27Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei133Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013403 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000432106; ENSP00000411536; ENSG00000138074
UCSCiuc061hlh.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013403 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE7ENG0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE7ENG0
PeptideAtlasiE7ENG0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432106; ENSP00000411536; ENSG00000138074
UCSCiuc061hlh.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000138074.14
HGNCiHGNC:11041 SLC5A6
OpenTargetsiENSG00000138074
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2349 Eukaryota
COG0591 LUCA
GeneTreeiENSGT00760000118955

Miscellaneous databases

ChiTaRSiSLC5A6 human

Gene expression databases

BgeeiENSG00000138074 Expressed in 182 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiE7ENG0 baseline and differential

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
PfamiView protein in Pfam
PF00474 SSF, 1 hit
PROSITEiView protein in PROSITE
PS50283 NA_SOLUT_SYMP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE7ENG0_HUMAN
AccessioniPrimary (citable) accession number: E7ENG0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 12, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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