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Entry version 80 (17 Jun 2020)
Sequence version 1 (08 Mar 2011)
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Protein
Submitted name:

E3 ubiquitin-protein ligase UBR5

Gene

UBR5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.SAAS annotation EC:2.3.2.26

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2761Glycyl thioester intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1171 – 1239UBR-typePROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processUbl conjugation pathwayPROSITE-ProRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
E3 ubiquitin-protein ligase UBR5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBR5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000104517.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16806 UBR5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000104517

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E7EMW7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E7EMW7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E7EMW7

PeptideAtlas

More...
PeptideAtlasi
E7EMW7

PRoteomics IDEntifications database

More...
PRIDEi
E7EMW7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
17027

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E7EMW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104517 Expressed in testis and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7EMW7 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1171 – 1239UBR-typeInterPro annotationAdd BLAST69
Domaini2371 – 2448PABCInterPro annotationAdd BLAST78
Domaini2497 – 2792HECTInterPro annotationAdd BLAST296

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 175DisorderedSequence analysisAdd BLAST99
Regioni322 – 346DisorderedSequence analysisAdd BLAST25
Regioni573 – 642DisorderedSequence analysisAdd BLAST70
Regioni993 – 1025DisorderedSequence analysisAdd BLAST33
Regioni1046 – 1069DisorderedSequence analysisAdd BLAST24
Regioni1293 – 1312DisorderedSequence analysisAdd BLAST20
Regioni1509 – 1734DisorderedSequence analysisAdd BLAST226
Regioni1853 – 1884DisorderedSequence analysisAdd BLAST32
Regioni1978 – 2015DisorderedSequence analysisAdd BLAST38
Regioni2111 – 2136DisorderedSequence analysisAdd BLAST26
Regioni2317 – 2386DisorderedSequence analysisAdd BLAST70
Regioni2467 – 2494DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili15 – 35Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 151PolarSequence analysisAdd BLAST65
Compositional biasi322 – 338PolyampholyteSequence analysisAdd BLAST17
Compositional biasi577 – 596PolyampholyteSequence analysisAdd BLAST20
Compositional biasi605 – 626PolarSequence analysisAdd BLAST22
Compositional biasi1011 – 1025Pro-richSequence analysisAdd BLAST15
Compositional biasi1046 – 1066PolarSequence analysisAdd BLAST21
Compositional biasi1515 – 1545PolarSequence analysisAdd BLAST31
Compositional biasi1557 – 1571AcidicSequence analysisAdd BLAST15
Compositional biasi1572 – 1601PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1616 – 1645PolarSequence analysisAdd BLAST30
Compositional biasi1654 – 1679PolarSequence analysisAdd BLAST26
Compositional biasi1687 – 1734PolarSequence analysisAdd BLAST48
Compositional biasi1870 – 1884PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1990 – 2008PolyampholyteSequence analysisAdd BLAST19
Compositional biasi2323 – 2364PolyampholyteSequence analysisAdd BLAST42
Compositional biasi2467 – 2484PolyampholyteSequence analysisAdd BLAST18

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1171 – 1239UBR-typePROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0943 Eukaryota
COG5021 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156357

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000257_0_0_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14423 CUE_UBR5, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024725 E3_UbLigase_EDD_UBA
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR036053 PABP-dom
IPR002004 PABP_HYD
IPR009091 RCC1/BLIP-II
IPR003126 Znf_UBR

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11547 E3_UbLigase_EDD, 1 hit
PF00632 HECT, 1 hit
PF00658 PABP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119 HECTc, 1 hit
SM00517 PolyA, 1 hit
SM00396 ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50985 SSF50985, 1 hit
SSF56204 SSF56204, 1 hit
SSF63570 SSF63570, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237 HECT, 1 hit
PS51309 PABC, 1 hit
PS51157 ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E7EMW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ
60 70 80 90 100
CVVGPNHAAF LLEDGRVCRI GFSVQPDRLE LGKPDNNDGS KLNSNSGAGR
110 120 130 140 150
TSRPGRTSDS PWFLSGSETL GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG
160 170 180 190 200
ARDSRRQTRV IRTGRDRGSG LLGSQPQPVI PASVIPEELI SQAQVVLQGK
210 220 230 240 250
SRSVIIRELQ RTNLDVNLAV NNLLSRDDED GDDGDDTASE SYLPGEDLMS
260 270 280 290 300
LLDADIHSAH PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRERDSE
310 320 330 340 350
LLRERESVLR LRERRWLDGA SFDNERGSTS KEGEPNLDKK NTPVQSPVSL
360 370 380 390 400
GEDLQWWPDK DGTKFICIGA LYSELLAVSS KGELYQWKWS ESEPYRNAQN
410 420 430 440 450
PSLHHPRATF LGLTNEKIVL LSANSIRATV ATENNKVATW VDETLSSVAS
460 470 480 490 500
KLEHTAQTYS ELQGERIVSL HCCALYTCAQ LENSLYWWGV VPFSQRKKML
510 520 530 540 550
EKARAKNKKP KSSAGISSMP NITVGTQVCL RNNPLYHAGA VAFSISAGIP
560 570 580 590 600
KVGVLMESVW NMNDSCRFQL RSPESLKNME KASKTTEAKP ESKQEPVKTE
610 620 630 640 650
MGPPPSPAST CSDASSIASS ASMPYKRRRS TPAPKEEEKV NEEQWSLREV
660 670 680 690 700
VFVEDVKNVP VGKVLKVDGA YVAVKFPGTS SNTNCQNSSG PDADPSSLLQ
710 720 730 740 750
DCRLLRIDEL QVVKTGGTPK VPDCFQRTPK KLCIPEKTEI LAVNVDSKGV
760 770 780 790 800
HAVLKTGNWV RYCIFDLATG KAEQENNFPT SSIAFLGQNE RNVAIFTAGQ
810 820 830 840 850
ESPIILRDGN GTIYPMAKDC MGGIRDPDWL DLPPISSLGM GVHSLINLPA
860 870 880 890 900
NSTIKKKAAV IIMAVEKQTL MQHILRCDYE ACRQYLMNLE QAVVLEQNLQ
910 920 930 940 950
MLQTFISHRC DGNRNILHAC VSVCFPTSNK ETKEEEEAER SERNTFAERL
960 970 980 990 1000
SAVEAIANAI SVVSSNGPGN RAGSSSSRSL RLREMMRRSL RAAGLGRHEA
1010 1020 1030 1040 1050
GASSSDHQDP VSPPIAPPSW VPDPPAMDPD GDIDFILAPA VGSLTTAATG
1060 1070 1080 1090 1100
TGQGPSTSTI PGPSTEPSVV ESKDRKANAH FILKLLCDSV VLQPYLRELL
1110 1120 1130 1140 1150
SAKDARGMTP FMSAVSGRAY PAAITILETA QKIAKAEISS SEKEEDVFMG
1160 1170 1180 1190 1200
MVCPSGTNPD DSPLYVLCCN DTCSFTWTGA EHINQDIFEC RTCGLLESLC
1210 1220 1230 1240 1250
CCTECARVCH KGHDCKLKRT SPTAYCDCWE KCKCKTLIAG QKSARLDLLY
1260 1270 1280 1290 1300
RLLTATNLVT LPNSRGEHLL LFLVQTVARQ TVEHCQYRPP RIREDRNRKT
1310 1320 1330 1340 1350
ASPEDSDMPD HDLEPPRFAQ LALERVLQDW NALKSMIMFG SQENKDPLSA
1360 1370 1380 1390 1400
SSRIGHLLPE EQVYLNQQSG TIRLDCFTHC LIVKCTADIL LLDTLLGTLV
1410 1420 1430 1440 1450
KELQNKYTPG RREEAIAVTM RFLRSVARVF VILSVEMASS KKKNNFIPQP
1460 1470 1480 1490 1500
IGKCKRVFQA LLPYAVEELC NVAESLIVPV RMGIARPTAP FTLASTSIDA
1510 1520 1530 1540 1550
MQGSEELFSV EPLPPRPSSD QSSSSSQSQS SYIIRNPQQR RISQSQPVRG
1560 1570 1580 1590 1600
RDEEQDDIVS ADVEEVEVVE GVAGEEDHHD EQEEHGEENA EAEGQHDEHD
1610 1620 1630 1640 1650
EDGSDMELDL LAAAETESDS ESNHSNQDNA SGRRSVVTAA TAGSEAGASS
1660 1670 1680 1690 1700
VPAFFSEDDS QSNDSSDSDS SSSQSDDIEQ ETFMLDEPLE RTTNSSHANG
1710 1720 1730 1740 1750
AAQAPRSMQW AVRNTQHQRA ASTAPSSTST PAASSAGLIY IDPSNLRRSG
1760 1770 1780 1790 1800
TISTSAAAAA AALEASNASS YLTSASSLAR AYSIVIRQIS DLMGLIPKYN
1810 1820 1830 1840 1850
HLVYSQIPAA VKLTYQDAVN LQNYVEEKLI PTWNWMVSIM DSTEAQLRYG
1860 1870 1880 1890 1900
SALASAGDPG HPNHPLHASQ NSARRERMTA REEASLRTLE GRRRATLLSA
1910 1920 1930 1940 1950
RQGMMSARGD FLNYALSLMR SHNDEHSDVL PVLDVCSLKH VAYVFQALIY
1960 1970 1980 1990 2000
WIKAMNQQTT LDTPQLERKR TRELLELGID NEDSEHENDD DTNQSATLND
2010 2020 2030 2040 2050
KDDDSLPAET GQNHPFFRRS DSMTFLGCIP PNPFEVPLAE AIPLADQPHL
2060 2070 2080 2090 2100
LQPNARKEDL FGRPSQGLYS SSASSGKCLM EVTVDRNCLE VLPTKMSYAA
2110 2120 2130 2140 2150
NLKNVMNMQN RQKKEGEEQP VLPEETESSK PGPSAHDLAA QLKSSLLAEI
2160 2170 2180 2190 2200
GLTESEGPPL TSFRPQCSFM GMVISHDMLL GRWRLSLELF GRVFMEDVGA
2210 2220 2230 2240 2250
EPGSILTELG GFEVKESKFR REMEKLRNQQ SRDLSLEVDR DRDLLIQQTM
2260 2270 2280 2290 2300
RQLNNHFGRR CATTPMAVHR VKVTFKDEPG EGSGVARSFY TAIAQAFLSN
2310 2320 2330 2340 2350
EKLPNLECIQ NANKGTHTSL MQRLRNRGER DREREREREM RRSSGLRAGS
2360 2370 2380 2390 2400
RRDRDRDFRR QLSIDTRPFR PASEGNPSDD PEPLPAHRQA LGERLYPRVQ
2410 2420 2430 2440 2450
AMQPAFASKI TGMLLELSPA QLLLLLASED SLRARVDEAM ELIIAHGREN
2460 2470 2480 2490 2500
GADSILDLGL VDSSEKVQEN RKRHGSSRSV VDMDLDDTDD GDDNAPLFYQ
2510 2520 2530 2540 2550
PGKRGFYTPR PGKNTEARLN CFRNIGRILG LCLLQNELCP ITLNRHVIKV
2560 2570 2580 2590 2600
LLGRKVNWHD FAFFDPVMYE SLRQLILASQ SSDADAVFSA MDLAFAIDLC
2610 2620 2630 2640 2650
KEEGGGQVEL IPNGVNIPVT PQNVYEYVRK YAEHRMLVVA EQPLHAMRKG
2660 2670 2680 2690 2700
LLDVLPKNSL EDLTAEDFRL LVNGCGEVNV QMLISFTSFN DESGENAEKL
2710 2720 2730 2740 2750
LQFKRWFWSI VEKMSMTERQ DLVYFWTSSP SLPASEEGFQ PMPSITIRPP
2760 2770 2780 2790
DDQHLPTANT CISRLYVPLY SSKQILKQKL LLAIKTKNFG FV
Length:2,792
Mass (Da):308,575
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE752BCAC6451DAC3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O95071UBR5_HUMAN
E3 ubiquitin-protein ligase UBR5
UBR5 EDD, EDD1, HYD, KIAA0896
2,799Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ET84E7ET84_HUMAN
E3 ubiquitin-protein ligase UBR5
UBR5
527Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAV7H0YAV7_HUMAN
E3 ubiquitin-protein ligase UBR5
UBR5
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBB4H0YBB4_HUMAN
E3 ubiquitin-protein ligase UBR5
UBR5
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFK7E5RFK7_HUMAN
E3 ubiquitin-protein ligase UBR5
UBR5
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP002907 Genomic DNA No translation available.
AP002981 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000521922; ENSP00000427819; ENSG00000104517

UCSC genome browser

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UCSCi
uc064pfu.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002907 Genomic DNA No translation available.
AP002981 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiE7EMW7

Proteomic databases

EPDiE7EMW7
jPOSTiE7EMW7
MaxQBiE7EMW7
PeptideAtlasiE7EMW7
PRIDEiE7EMW7
ProteomicsDBi17027

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
13236 274 antibodies

Genome annotation databases

EnsembliENST00000521922; ENSP00000427819; ENSG00000104517
UCSCiuc064pfu.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000104517.12
HGNCiHGNC:16806 UBR5
OpenTargetsiENSG00000104517

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0943 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00940000156357
HOGENOMiCLU_000257_0_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UBR5 human

Gene expression databases

BgeeiENSG00000104517 Expressed in testis and 228 other tissues
ExpressionAtlasiE7EMW7 baseline and differential

Family and domain databases

CDDicd14423 CUE_UBR5, 1 hit
InterProiView protein in InterPro
IPR024725 E3_UbLigase_EDD_UBA
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR036053 PABP-dom
IPR002004 PABP_HYD
IPR009091 RCC1/BLIP-II
IPR003126 Znf_UBR
PfamiView protein in Pfam
PF11547 E3_UbLigase_EDD, 1 hit
PF00632 HECT, 1 hit
PF00658 PABP, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SM00517 PolyA, 1 hit
SM00396 ZnF_UBR1, 1 hit
SUPFAMiSSF50985 SSF50985, 1 hit
SSF56204 SSF56204, 1 hit
SSF63570 SSF63570, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit
PS51309 PABC, 1 hit
PS51157 ZF_UBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7EMW7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7EMW7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: June 17, 2020
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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