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Protein
Submitted name:

Eukaryotic initiation factor 4A-II

Gene

EIF4A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic initiation factor 4A-IIImported
Gene namesi
Name:EIF4A2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000156976.14
HGNCiHGNC:3284 EIF4A2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156976

PTM / Processingi

Proteomic databases

MaxQBiE7EMV8
PeptideAtlasiE7EMV8
PRIDEiE7EMV8

Expressioni

Gene expression databases

BgeeiENSG00000156976 Expressed in 247 organ(s), highest expression level in Brodmann (1909) area 46
ExpressionAtlasiE7EMV8 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE7EMV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 61Q_MOTIFInterPro annotationAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 61Q motifPROSITE-ProRule annotationAdd BLAST29

Phylogenomic databases

eggNOGiKOG0327 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00530000062880

Family and domain databases

InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR037583 EIF4A
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
PANTHERiPTHR24031:SF226 PTHR24031:SF226, 1 hit
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51195 Q_MOTIF, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

E7EMV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGSADYNR EHGGPEGMDP DGVIESNWNE IVDNFDDMNL KESLLRGIYA
60 70 80 90
YGFEKPSAIQ QRAIIPCIKG YDVIAQAQSG TGKTATFAIS ILQQLEIE
Length:98
Mass (Da):10,697
Last modified:March 8, 2011 - v1
Checksum:iAEFD62F6FBD86B04
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q14240IF4A2_HUMAN
Eukaryotic initiation factor 4A-II
EIF4A2 DDX2B, EIF4F
407Annotation score:
E7EQG2E7EQG2_HUMAN
Eukaryotic initiation factor 4A-II
EIF4A2
362Annotation score:
J3KSN7J3KSN7_HUMAN
Eukaryotic initiation factor 4A-II
EIF4A2
109Annotation score:
F8WE11F8WE11_HUMAN
Eukaryotic initiation factor 4A-II
EIF4A2
97Annotation score:
C9JUF0C9JUF0_HUMAN
Eukaryotic initiation factor 4A-II
EIF4A2
57Annotation score:
E9PBH4E9PBH4_HUMAN
Eukaryotic initiation factor 4A-II
EIF4A2
96Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei98Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112907 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000445596; ENSP00000415878; ENSG00000156976
UCSCiuc062reh.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112907 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE7EMV8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE7EMV8
PeptideAtlasiE7EMV8
PRIDEiE7EMV8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445596; ENSP00000415878; ENSG00000156976
UCSCiuc062reh.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000156976.14
HGNCiHGNC:3284 EIF4A2
OpenTargetsiENSG00000156976
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0327 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00530000062880

Miscellaneous databases

ChiTaRSiEIF4A2 human

Gene expression databases

BgeeiENSG00000156976 Expressed in 247 organ(s), highest expression level in Brodmann (1909) area 46
ExpressionAtlasiE7EMV8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR037583 EIF4A
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
PANTHERiPTHR24031:SF226 PTHR24031:SF226, 1 hit
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51195 Q_MOTIF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE7EMV8_HUMAN
AccessioniPrimary (citable) accession number: E7EMV8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 12, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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