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Protein
Submitted name:

Thrombospondin type-1 domain-containing protein 7B

Gene

THSD7B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Names & Taxonomyi

Protein namesi
Submitted name:
Thrombospondin type-1 domain-containing protein 7BImported
Gene namesi
Name:THSD7BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144229.11
HGNCiHGNC:29348 THSD7B

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1556 – 1580HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144229

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
ChainiPRO_500321730237 – 1606Sequence analysisAdd BLAST1570

Proteomic databases

PRIDEiE7EM75

Expressioni

Gene expression databases

BgeeiENSG00000144229 Expressed in 108 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiE7EM75 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE7EM75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XR0P LUCA
GeneTreeiENSGT00930000150896

Family and domain databases

Gene3Di2.20.100.10, 10 hits
InterProiView protein in InterPro
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00090 TSP_1, 8 hits
SMARTiView protein in SMART
SM00209 TSP1, 16 hits
SUPFAMiSSF82895 SSF82895, 12 hits
PROSITEiView protein in PROSITE
PS50092 TSP1, 13 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E7EM75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPKSNLTVT CWVWRSMRKL FLLLSLLLSH AAHLEGKKDN QFIWKPGPWG
60 70 80 90 100
RCTGDCGPGG VQSRAVWCFH VDGWTSHLSN CGESNRPPKE RSCFRVCDWH
110 120 130 140 150
SDLFQWEVSD WHHCVLVPYA RGEVKPRTAE CVTAQHGLQH RMVRCIQKLN
160 170 180 190 200
RTVVANEICE HFALQPPTEQ ACLIPCPRDC VVSEFLPWSN CSKGCGKKLQ
210 220 230 240 250
HRTRAVIAPP LFGGLQCPNL TESRACDAPI SCPLGEEEYT FSLKVGPWSK
260 270 280 290 300
CRLPHLKEIN PSGRTVLDFN SDSNERVTFK HQSYKAHHHS KSWAIEIGYQ
310 320 330 340 350
TRQVSCTRSD GQNAMLSLCL QDSFPLTVQS CIMPKDCETS QWSSWSPCSK
360 370 380 390 400
TCRSGSLLPG FRSRSRNVKH MAIGGGKECP ELLEKEACIV EGELLQQCPR
410 420 430 440 450
YSWRTSEWKE CQVSLLLEQQ DPHWHVTGPV CGGGIQTREV YCAQSVPAAA
460 470 480 490 500
ALRAKEVSRP VEKALCVGPA PLPSQLCNIP CSTDCIVSSW SAWGLCIHEN
510 520 530 540 550
CHDPQGKKGF RTRQRHVLME STGPAGHCPH LVESVPCEDP MCYRWLASEG
560 570 580 590 600
ICFPDHGKCG LGHRILKAVC QNDRGEDVSG SLCPVPPPPE RKSCEIPCRM
610 620 630 640 650
DCVLSEWTEW SSCSQSCSNK NSDGKQTRSR TILALAGEGG KPCPPSQALQ
660 670 680 690 700
EHRLCNDHSC MQLHWETSPW GPCSEDTLVT ALNATIGWNG EATCGVGIQT
710 720 730 740 750
RRVFCVKSHV GQVMTKRCPD STRPETVRPC FLPCKKDCIV TAFSEWTPCP
760 770 780 790 800
RMCQAGNATV KQSRYRIIIQ EAANGGQECP DTLYEERECE DVSLCPVYRW
810 820 830 840 850
KPQKWSPCIL VPESVWQGIT GSSEACGKGL QTRAVSCISD DNRSAEMMEC
860 870 880 890 900
LKQTNGMPLL VQECTVPCRE DCTFTAWSKF TPCSTNCEAT KSRRRQLTGK
910 920 930 940 950
SRKKEKCQDS DLYPLVETEL CPCDEFISQP YGNWSDCILP EGRREPHRGL
960 970 980 990 1000
RVQADSKECG EGLRFRAVAC SDKNGRPVDP SFCSSSGYIQ EKCVIPCPFD
1010 1020 1030 1040 1050
CKLSDWSSWG SCSSSCGIGV RIRSKWLKEK PYNGGRPCPK LDLKNQVHEA
1060 1070 1080 1090 1100
VPCYSECNQY SWVVEHWSSC KINNELRSLR CGGGTQSRKI RCVNTADGEG
1110 1120 1130 1140 1150
GAVDSNLCNQ DEIPPETQSC SLMCPNECVM SEWGLWSKCP QSCDPHTMQR
1160 1170 1180 1190 1200
RTRHLLRPSL NSRTCAEDSQ VQPCLLNENC FQFQYNLTEW STCQLSENAP
1210 1220 1230 1240 1250
CGQGVRTRLL SCVCSDGKPV SMDQCEQHNL EKPQRMSIPC LVECVVNCQL
1260 1270 1280 1290 1300
SGWTAWTECS QTCGHGGRMS RTRFIIMPTQ GEGRPCPTEL TQEKTCPVTP
1310 1320 1330 1340 1350
CYSWVLGNWS ACKLEGGDCG EGVQIRSLSC MVHSGSISHA AGRVEDALCG
1360 1370 1380 1390 1400
EMPFQDSILK QLCSVPCPGD CHLTEWSEWS TCELTCIDGR SFETVGRQSR
1410 1420 1430 1440 1450
SRTFIIQSFE NQDSCPQQVL ETRPCTGGKC YHYTWKASLW NNNERTVWCQ
1460 1470 1480 1490 1500
RSDGVNVTGG CSPQARPAAI RQCIPACRKP FSYCTQGGVC GCEKGYTEIM
1510 1520 1530 1540 1550
KSNGFLDYCM KVPGSEDKKA DVKNLSGKNR PVNSKIHDIF KGWSLQPLDP
1560 1570 1580 1590 1600
DGRVKIWVYG VSGGAFLIMI FLIFTSYLVC KKPKPHQSTP PQQKPLTLAY

DGDLDM
Length:1,606
Mass (Da):179,199
Last modified:March 8, 2011 - v1
Checksum:i0947780C9CAD0B8C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9C0I4THS7B_HUMAN
Thrombospondin type-1 domain-contai...
THSD7B KIAA1679
1,608Annotation score:
C9JKN6C9JKN6_HUMAN
Thrombospondin type-1 domain-contai...
THSD7B
1,577Annotation score:
R4GMU2R4GMU2_HUMAN
Thrombospondin type-1 domain-contai...
THSD7B
50Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010100 Genomic DNA No translation available.
AC010873 Genomic DNA No translation available.
AC011231 Genomic DNA No translation available.
AC012000 Genomic DNA No translation available.
AC016679 Genomic DNA No translation available.
AC017082 Genomic DNA No translation available.
AC019067 Genomic DNA No translation available.
KF456714 Genomic DNA No translation available.
RefSeqiNP_001303278.1, NM_001316349.1
UniGeneiHs.68533

Genome annotation databases

EnsembliENST00000409968; ENSP00000387145; ENSG00000144229
GeneIDi80731
KEGGihsa:80731
UCSCiuc061ock.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010100 Genomic DNA No translation available.
AC010873 Genomic DNA No translation available.
AC011231 Genomic DNA No translation available.
AC012000 Genomic DNA No translation available.
AC016679 Genomic DNA No translation available.
AC017082 Genomic DNA No translation available.
AC019067 Genomic DNA No translation available.
KF456714 Genomic DNA No translation available.
RefSeqiNP_001303278.1, NM_001316349.1
UniGeneiHs.68533

3D structure databases

ProteinModelPortaliE7EM75
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE7EM75

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409968; ENSP00000387145; ENSG00000144229
GeneIDi80731
KEGGihsa:80731
UCSCiuc061ock.1 human

Organism-specific databases

CTDi80731
EuPathDBiHostDB:ENSG00000144229.11
HGNCiHGNC:29348 THSD7B
OpenTargetsiENSG00000144229
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XR0P LUCA
GeneTreeiENSGT00930000150896

Miscellaneous databases

ChiTaRSiTHSD7B human

Gene expression databases

BgeeiENSG00000144229 Expressed in 108 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiE7EM75 baseline and differential

Family and domain databases

Gene3Di2.20.100.10, 10 hits
InterProiView protein in InterPro
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00090 TSP_1, 8 hits
SMARTiView protein in SMART
SM00209 TSP1, 16 hits
SUPFAMiSSF82895 SSF82895, 12 hits
PROSITEiView protein in PROSITE
PS50092 TSP1, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE7EM75_HUMAN
AccessioniPrimary (citable) accession number: E7EM75
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 7, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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