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Entry version 57 (12 Aug 2020)
Sequence version 1 (08 Mar 2011)
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Protein

Thiol:disulfide interchange protein

Gene

trbB

Organism
Escherichia coli
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomeraseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thiol:disulfide interchange proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trbBImported
ORF Names:BMA87_23085Imported, BMA87_28470Imported, BvCmsHHP001_04380Imported, BvCmsKKP036_00903Imported, D4U49_22380Imported, D4U49_28605Imported, D6T98_18525Imported, DL326_14550Imported, DLX38_21065Imported, DLX38_27745Imported, DM272_24735Imported, DM272_27730Imported, EHJ36_26800Imported, EPT01_20930Imported, FNJ69_25405Imported, FY127_08960Imported, HUS41_pI0068Imported, RCS90_PI0039Imported, SAMEA3472147_02795Imported, SK85_04777Imported, WQ89_24590Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid RCS90_pIImported
Plasmid p168-2Imported
Plasmid p3521Imported
Plasmid pHUSEC41-1Imported
Plasmid rcs90_piImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coliImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000036012 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000366423 Componenti: Unassembled WGS sequence
  • UP000250899 Componenti: Unassembled WGS sequence
  • UP000301113 Componenti: Unassembled WGS sequence
  • UP000373361 Componenti: Unassembled WGS sequence
  • UP000343782 Componenti: Unassembled WGS sequence
  • UP000404131 Componenti: Unassembled WGS sequence
  • UP000346445 Componenti: Unassembled WGS sequence
  • UP000413862 Componenti: Unassembled WGS sequence
  • UP000306525 Componenti: Plasmid rcs90_pi
  • UP000290456 Componenti: Unassembled WGS sequence
  • UP000322733 Componenti: Unassembled WGS sequence
  • UP000036812 Componenti: Unassembled WGS sequence
  • UP000315393 Componenti: Plasmid p168-2
  • UP000301935 Componenti: Unassembled WGS sequence
  • UP000376288 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei104 – 128HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, PeriplasmUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini222 – 339Thioredoxin-like_foldInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni138 – 195DisorderedSequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi149 – 163PolyampholyteSequence analysisAdd BLAST15
Compositional biasi168 – 186PolarSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thioredoxin family. DsbC subfamily.UniRule annotationARBA annotation

Keywords - Domaini

Redox-active centerUniRule annotationARBA annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03020, DsbA_DsbC_DsbG, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033954, DiS-bond_Isoase_DsbC/G
IPR012336, Thioredoxin-like_fold
IPR036249, Thioredoxin-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13098, Thioredoxin_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833, SSF52833, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7BTB7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIHYTATLN NKHLSLIALY PDGNREVIAI LPVTELGALI NRNNRLMHLS
60 70 80 90 100
FSSPFREITE TVLVDTVDAE RPGHHIGRML SAIDACLDAE YAGKGKHPSR
110 120 130 140 150
KNGFWRTLMC GFIAGIALPA TVAGYHWMKA EPPSTLAYPT SQEWRAEPVT
160 170 180 190 200
DTETPRPHTE HHVNSIPARP APTQQEPSSA PAPTAVTEEQ HVQAAEARRN
210 220 230 240 250
LATVLKRNAD RGMFTINLST GHERTLYAFL DPACINCRLL EPALKQLARE
260 270 280 290 300
FSVVIYPVSV IGGESSTKRT APLLCEPDSQ KRATGWHQLY SADSGMAPTG
310 320 330 340 350
DAPAAQDGQC LTAARAAIDV NNQAFRQFGF GGTPWVLSDT GWHLPSGILK
360 370
DATSVRLFLK ATDSEEYHNE PAPR
Length:374
Mass (Da):40,942
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8828CD61674AACCA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GU256641 Genomic DNA Translation: ADB84917.1
HE603110 Genomic DNA Translation: CCE21087.1
AAAAKE010000110 Genomic DNA Translation: EAA0954421.1
AAAAKE010000426 Genomic DNA Translation: EAA0955638.1
AAAAMO010000016 Genomic DNA Translation: EAA1118308.1
AAAASZ010000116 Genomic DNA Translation: EAA1960505.1
AAAASZ010000309 Genomic DNA Translation: EAA1961036.1
AAADOH010000078 Genomic DNA Translation: EAB1137140.1
AAAFLE010000034 Genomic DNA Translation: EAB6683504.1
AAAFMF010000069 Genomic DNA Translation: EAB6864294.1
AAAFMF010000282 Genomic DNA Translation: EAB6865255.1
AAAFOP010000092 Genomic DNA Translation: EAB7205221.1
AAAFOP010000309 Genomic DNA Translation: EAB7206346.1
BFKI01000158 Genomic DNA Translation: GCR90420.1
BFXJ01000024 Genomic DNA Translation: GDG83187.1
LEUM01000029 Genomic DNA Translation: KLX89778.1
LGZP01000062 Genomic DNA Translation: KNF74760.1
CP041565 Genomic DNA Translation: QDN33412.1
SCIR01000046 Genomic DNA Translation: RXB60733.1
LT985300 Genomic DNA Translation: SPE03536.1
UCZG01000025 Genomic DNA Translation: SQP97496.1
VTAZ01000019 Genomic DNA Translation: TYR57954.1

NCBI Reference Sequences

More...
RefSeqi
WP_000152378.1, NZ_WTQN01000014.1
YP_004119716.1, NC_014843.1
YP_006940098.1, NC_018995.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CRL88807; CRL88807; AL505_190002
KLX89778; KLX89778; SK85_04777
KNF74760; KNF74760; WQ89_24590
KQJ15652; KQJ15652; AM266_11920
KXQ42670; KXQ42670; AUQ01_01565
OAO65853; OAO65853; OO96_19515
OAO69060; OAO69060; OK10_25055

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10076125
13877058

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|562.10476.peg.2661

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU256641 Genomic DNA Translation: ADB84917.1
HE603110 Genomic DNA Translation: CCE21087.1
AAAAKE010000110 Genomic DNA Translation: EAA0954421.1
AAAAKE010000426 Genomic DNA Translation: EAA0955638.1
AAAAMO010000016 Genomic DNA Translation: EAA1118308.1
AAAASZ010000116 Genomic DNA Translation: EAA1960505.1
AAAASZ010000309 Genomic DNA Translation: EAA1961036.1
AAADOH010000078 Genomic DNA Translation: EAB1137140.1
AAAFLE010000034 Genomic DNA Translation: EAB6683504.1
AAAFMF010000069 Genomic DNA Translation: EAB6864294.1
AAAFMF010000282 Genomic DNA Translation: EAB6865255.1
AAAFOP010000092 Genomic DNA Translation: EAB7205221.1
AAAFOP010000309 Genomic DNA Translation: EAB7206346.1
BFKI01000158 Genomic DNA Translation: GCR90420.1
BFXJ01000024 Genomic DNA Translation: GDG83187.1
LEUM01000029 Genomic DNA Translation: KLX89778.1
LGZP01000062 Genomic DNA Translation: KNF74760.1
CP041565 Genomic DNA Translation: QDN33412.1
SCIR01000046 Genomic DNA Translation: RXB60733.1
LT985300 Genomic DNA Translation: SPE03536.1
UCZG01000025 Genomic DNA Translation: SQP97496.1
VTAZ01000019 Genomic DNA Translation: TYR57954.1
RefSeqiWP_000152378.1, NZ_WTQN01000014.1
YP_004119716.1, NC_014843.1
YP_006940098.1, NC_018995.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiCRL88807; CRL88807; AL505_190002
KLX89778; KLX89778; SK85_04777
KNF74760; KNF74760; WQ89_24590
KQJ15652; KQJ15652; AM266_11920
KXQ42670; KXQ42670; AUQ01_01565
OAO65853; OAO65853; OO96_19515
OAO69060; OAO69060; OK10_25055
GeneIDi10076125
13877058
PATRICifig|562.10476.peg.2661

Family and domain databases

CDDicd03020, DsbA_DsbC_DsbG, 1 hit
Gene3Di3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR033954, DiS-bond_Isoase_DsbC/G
IPR012336, Thioredoxin-like_fold
IPR036249, Thioredoxin-like_sf
PfamiView protein in Pfam
PF13098, Thioredoxin_2, 1 hit
SUPFAMiSSF52833, SSF52833, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7BTB7_ECOLX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7BTB7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: August 12, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

PlasmidImported
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