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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Desulfurispirillum indicum (strain ATCC BAA-1389 / S5)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotationSAAS annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotationSAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processCell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotationSAAS annotation (EC:2.4.1.227UniRule annotationSAAS annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:Selin_0431Imported
OrganismiDesulfurispirillum indicum (strain ATCC BAA-1389 / S5)Imported
Taxonomic identifieri653733 [NCBI]
Taxonomic lineageiBacteriaChrysiogenetesChrysiogenalesChrysiogenaceaeDesulfurispirillum
Proteomesi
  • UP000002572 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Protein-protein interaction databases

STRINGi653733.Selin_0431

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 139Glyco_transf_28InterPro annotationAdd BLAST137
Domaini170 – 301Glyco_tran_28_CInterPro annotationAdd BLAST132

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DVQ Bacteria
COG0707 LUCA
HOGENOMiHOG000218321
KOiK02563
OMAiHQTKNAM
OrthoDBiPOG091H02FX

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit

Sequencei

Sequence statusi: Complete.

E6W058-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRILISGGGT GGHFFPAMAA LKSFQEKGFD VYYVGSRRGI EAEKVAAFTA
60 70 80 90 100
DFLLLELSGM LGHSALKKLQ AGWQLVFAVK ELLLLMRRMR PDAVVGFGGY
110 120 130 140 150
SSAAAIIAGR LMGVPCFIHE QNAIAGLTNR LLDRVTTRSF SAYGNIGEHV
160 170 180 190 200
GLPLRHSALV PAPADEREHL LILGGSQGSL FLNTFVGDHL GELTDLGMPV
210 220 230 240 250
YHQTGSLMHE KHMQMLHERY GRQLPANYLP FAFSDDIHHI MAGSVAAISR
260 270 280 290 300
SGAGAAFELM QLRVPSLFIP FPHAAHDHQY ANAKYFEDRG CALVYRQEEF
310 320 330 340
ERGAMDKVRT FLSCVDQYHG NMQGLEIDTD ASTLTERIIG AIRMS
Length:345
Mass (Da):37,911
Last modified:March 8, 2011 - v1
Checksum:i4BFBC301F10A5896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002432 Genomic DNA Translation: ADU65184.1

Genome annotation databases

EnsemblBacteriaiADU65184; ADU65184; Selin_0431
KEGGidin:Selin_0431

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002432 Genomic DNA Translation: ADU65184.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi653733.Selin_0431

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU65184; ADU65184; Selin_0431
KEGGidin:Selin_0431

Phylogenomic databases

eggNOGiENOG4105DVQ Bacteria
COG0707 LUCA
HOGENOMiHOG000218321
KOiK02563
OMAiHQTKNAM
OrthoDBiPOG091H02FX

Enzyme and pathway databases

UniPathwayi
UPA00219

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE6W058_DESIS
AccessioniPrimary (citable) accession number: E6W058
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 27, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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