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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Ethanoligenens harbinense (strain DSM 18485 / JCM 12961 / CGMCC 1.5033 / YUAN-3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8SubstrateUniRule annotation1
Binding sitei12SubstrateUniRule annotation1
Active sitei60Proton acceptorUniRule annotation1
Active sitei60Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BioCyciEHAR663278:G1GPT-301-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotationSAAS annotation (EC:4.2.3.3UniRule annotationSAAS annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Ordered Locus Names:Ethha_0288Imported
OrganismiEthanoligenens harbinense (strain DSM 18485 / JCM 12961 / CGMCC 1.5033 / YUAN-3)Imported
Taxonomic identifieri663278 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeEthanoligenens
Proteomesi
  • UP000001551 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi663278.Ethha_0288

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108Z5K Bacteria
COG1803 LUCA
HOGENOMiHOG000283729
KOiK01734
OMAiFAWRELV
OrthoDBiPOG091H04UH

Family and domain databases

CDDicd01422 MGS, 1 hit
Gene3Di3.40.50.1380, 1 hit
HAMAPiMF_00549 Methylglyoxal_synth, 1 hit
InterProiView protein in InterPro
IPR004363 Methylgl_synth
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
PANTHERiPTHR30492 PTHR30492, 1 hit
PfamiView protein in Pfam
PF02142 MGS, 1 hit
PIRSFiPIRSF006614 Methylglyox_syn, 1 hit
SMARTiView protein in SMART
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
TIGRFAMsiTIGR00160 MGSA, 1 hit

Sequencei

Sequence statusi: Complete.

E6U7D9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIALIAHDA KKELIVQFCI AYCGILSRHS LCATGTTGKL IADATGLDIQ
60 70 80 90 100
RFLGGSQGGD QQISARIACN EIDLLLFFRD PLTPKPTEPK EMSMLRLCDV
110 120 130
HNIPVATNIA TAEVLVRALD RGDFDWRDIV NPKSK
Length:135
Mass (Da):14,808
Last modified:March 8, 2011 - v1
Checksum:iD94D398F22E861AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002400 Genomic DNA Translation: ADU25874.1
RefSeqiWP_013484255.1, NZ_CP025286.1

Genome annotation databases

EnsemblBacteriaiADU25874; ADU25874; Ethha_0288
KEGGieha:Ethha_0288

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002400 Genomic DNA Translation: ADU25874.1
RefSeqiWP_013484255.1, NZ_CP025286.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi663278.Ethha_0288

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU25874; ADU25874; Ethha_0288
KEGGieha:Ethha_0288

Phylogenomic databases

eggNOGiENOG4108Z5K Bacteria
COG1803 LUCA
HOGENOMiHOG000283729
KOiK01734
OMAiFAWRELV
OrthoDBiPOG091H04UH

Enzyme and pathway databases

BioCyciEHAR663278:G1GPT-301-MONOMER

Family and domain databases

CDDicd01422 MGS, 1 hit
Gene3Di3.40.50.1380, 1 hit
HAMAPiMF_00549 Methylglyoxal_synth, 1 hit
InterProiView protein in InterPro
IPR004363 Methylgl_synth
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
PANTHERiPTHR30492 PTHR30492, 1 hit
PfamiView protein in Pfam
PF02142 MGS, 1 hit
PIRSFiPIRSF006614 Methylglyox_syn, 1 hit
SMARTiView protein in SMART
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
TIGRFAMsiTIGR00160 MGSA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE6U7D9_ETHHY
AccessioniPrimary (citable) accession number: E6U7D9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 7, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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