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Protein

Alanine racemase

Gene

Bcell_0339

Organism
Bacillus cellulosilyticus (strain ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Bcell_0339)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei42Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei141SubstrateUniRule annotation1
Active sitei274Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei321Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBCEL649639:G1GPN-365-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Bcell_0339Imported
OrganismiBacillus cellulosilyticus (strain ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4)Imported
Taxonomic identifieri649639 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001401 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi649639.Bcell_0339

Structurei

3D structure databases

ProteinModelPortaliE6TV42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini253 – 378Ala_racemase_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit

Sequencei

Sequence statusi: Complete.

E6TV42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTNHFYRN TWVEVDLNAI RENVKNLKNH LPSHVHIMAA VKANGYGHSS
60 70 80 90 100
VPVAEAALQA GATYLGVALL DEAIELRENG IKAPILVLGY VSPKYVNVAA
110 120 130 140 150
EYDIRLTVFQ SEWVEEAAKV LEADNKGKIA CHVKIDTGMG RLGIRTKEEG
160 170 180 190 200
NALIVKLKKY SLFTIEGLFT HYATADELDT SYLELQQQRF KDMISWFEAT
210 220 230 240 250
WGAEVPMKHC GNSATALRFS SEYYNLVRYG ISMYGLSPSE EIKELLPFPL
260 270 280 290 300
KQAFSLYSEI THIKKAEKGD GISYGATYKS PGEEWIGTIP IGYADGWIRA
310 320 330 340 350
NATGEVLVNG ERVPIVGRIC MDQMMVALKQ PVQIGTKVTI IGKQGNSFIT
360 370 380
IDEVANRLNT INYEIPCTIG SRVPRIMVDK K
Length:381
Mass (Da):42,371
Last modified:March 8, 2011 - v1
Checksum:iBC4E7CBA6418698A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002394 Genomic DNA Translation: ADU28625.1
RefSeqiWP_013486966.1, NC_014829.1

Genome annotation databases

EnsemblBacteriaiADU28625; ADU28625; Bcell_0339
KEGGibco:Bcell_0339

Similar proteinsi

Entry informationi

Entry nameiE6TV42_BACCJ
AccessioniPrimary (citable) accession number: E6TV42
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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