Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA polymerase II transcription factor B subunit 2

Gene

CGB_N1600W

Organism
Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
Ordered Locus Names:CGB_N1600WImported
OrganismiCryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)Imported
Taxonomic identifieri367775 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus gattii species complex
Proteomesi
  • UP000007805 Componenti: Chromosome N

Organism-specific databases

EuPathDBiFungiDB:CGB_N1600W

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi367775.XP_003197492.1

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3471 Eukaryota
COG5144 LUCA
KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

E6RG20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQPSFSAPK KDVSKQASLT SALDIFLDNQ HQSYFEELYR LLPPVCRQII
60 70 80 90 100
LHALWSHHPL RVTDVKLLLQ MDVHAPLEEC DEVMRPAINR KVLHPMHYKK
110 120 130 140 150
QKMQWSLNDS FKRGLRNALT GLGASNSFGV PFERHQATDL DLPSKDELVA
160 170 180 190 200
YGEETFESIL KYMVSSGLGT EFSGSRPQPE VLQLLHASGL MTDPGDMSRR
210 220 230 240 250
NPNIYRLTIT SKGFQFLLEK RQTQLWEILM YYLSAKEANS ERSSEVLSMF
260 270 280 290 300
FSLGCMQLGQ DYSASNSFPH AQEALNDLAQ YGFIYKPSPD SDQFWPTHLA
310 320 330 340 350
TSLCSGDASA IQSQSADDKR FLILETNYKI YAYTSNELEI AILNLFVDIR
360 370 380 390 400
IRYPNLVVGK LDRQHVKAAM EKGISARQII AYLSSHAHPQ MYNSPPPLLH
410 420 430 440 450
PTIVDQLHLW DRERNRLQTE ETVMYEFFSK ELFDDTVNEA KANAALQHAA
460 470 480
TSQKLLFIEP HTKPAITEFV KQRQNVLRGG Y
Length:481
Mass (Da):54,919
Last modified:March 8, 2011 - v1
Checksum:i092A64B9AB4ED93D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000299 Genomic DNA Translation: ADV25705.1
RefSeqiXP_003197492.1, XM_003197444.1

Genome annotation databases

EnsemblFungiiADV25705; ADV25705; CGB_N1600W
GeneIDi10186516
KEGGicgi:CGB_N1600W

Similar proteinsi

Entry informationi

Entry nameiE6RG20_CRYGW
AccessioniPrimary (citable) accession number: E6RG20
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 28, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health