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Protein

Multifunctional tryptophan biosynthesis protein

Gene

CGB_H1160W

Organism
Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.UniRule annotation

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.UniRule annotation
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 1, 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Multifunctional tryptophan biosynthesis protein (CGB_H1160W)
  2. no protein annotated in this organism
  3. Multifunctional tryptophan biosynthesis protein (CGB_H1160W)
  4. Multifunctional tryptophan biosynthesis protein (CGB_H1160W)
  5. Tryptophan synthase (CGB_A7080C)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86NucleophilePROSITE-ProRule annotation1
Active sitei176PROSITE-ProRule annotation1
Active sitei178PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, IsomeraseUniRule annotation, Lyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040
UPA00035; UER00042
UPA00035; UER00043

Protein family/group databases

MEROPSiC26.959

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional tryptophan biosynthesis proteinUniRule annotation
Including the following 3 domains:
Anthranilate synthase component 2UniRule annotation (EC:4.1.3.27UniRule annotation)
Short name:
ASUniRule annotation
Alternative name(s):
Anthranilate synthase, glutamine amidotransferase componentUniRule annotation
Indole-3-glycerol phosphate synthaseUniRule annotation (EC:4.1.1.48UniRule annotation)
Short name:
IGPSUniRule annotation
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Ordered Locus Names:CGB_H1160WImported
OrganismiCryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)Imported
Taxonomic identifieri367775 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus gattii species complex
Proteomesi
  • UP000007805 Componenti: Chromosome H

Organism-specific databases

EuPathDBiFungiDB:CGB_H1160W

Interactioni

Protein-protein interaction databases

STRINGi367775.XP_003195590.1

Structurei

3D structure databases

ProteinModelPortaliE6RAF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 202Glutamine amidotransferase type-1InterPro annotationAdd BLAST200

Keywords - Domaini

Glutamine amidotransferasePROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0026 Eukaryota
KOG4201 Eukaryota
KOG4202 Eukaryota
COG0134 LUCA
COG0135 LUCA
COG0512 LUCA
KOiK13501
OrthoDBiEOG092C1PKC

Family and domain databases

CDDicd00331 IGPS, 1 hit
cd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 3 hits
3.40.50.880, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR016302 Anthranilate_synth_II
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR013798 Indole-3-glycerol_P_synth
IPR001468 Indole-3-GlycerolPSynthase_CS
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
IPR006221 TrpG/PapA_dom
PfamiView protein in Pfam
PF00117 GATase, 1 hit
PF00218 IGPS, 1 hit
PF00697 PRAI, 1 hit
PIRSFiPIRSF001382 TrpG-trpC-trpF, 1 hit
SUPFAMiSSF51366 SSF51366, 3 hits
SSF52317 SSF52317, 1 hit
TIGRFAMsiTIGR00566 trpG_papA, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit
PS00614 IGPS, 1 hit

Sequencei

Sequence statusi: Complete.

E6RAF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFTLLIDNY DSFTWNIYAD LASVGGNPYV VRNDKITLKE IERMFADGEL
60 70 80 90 100
ERIVISPGPG HPRTDSGVSR DVIAWGMGKL PILGVCMGLE CIVDLLGGEI
110 120 130 140 150
AYAGEIKHGK TSLVQHDSIG VFHSLPQFLS STRYHSLSAQ IQSVPSVLQV
160 170 180 190 200
TSTTKESGVI MGVRHRTYTV EAVQYHPESC MSEGGRGLMA NFIQMKGGKW
210 220 230 240 250
GGENAWCGVP AEGEEEQSKA KTNGAPSLPT ILNKIHAQRL LDVEQAEKIP
260 270 280 290 300
ATTPANVSTS LSLYTSPPLI NFRDRMVSTP HTAVMAEIKR ASPSKGDIAP
310 320 330 340 350
TASAPEQALK YALAGASVIS VLTEPTWFKG SVLDMLAVRN AVDSLPNRPA
360 370 380 390 400
ILRKDFVLSK YMIDEARLYG ADTVLLIVAM LAPQQLKELY DYSVSLGMEP
410 420 430 440 450
LVEVNNPTEL SLALEIGSKV IGVNNRNLHD FNVDMSTTSR VNAALNGRDV
460 470 480 490 500
VVCALSGISS HEDVEQYVKE GVKGVLVGEA LMRATDTKAF LRSLIGLPPL
510 520 530 540 550
EVVPKPKPLV KICGIRSADD AKLAISAGAD LLGVILVPGT KRCISTSTAR
560 570 580 590 600
EISALVQSAR SQSSSKPLEP SLSSPWFTTQ SALLSSRRKP LLVGVFQNQS
610 620 630 640 650
LSDILSAVDE IGLDLVQLHG DEPQAWAKFI PVPVIKVFRV SPEGIVRGGE
660 670 680 690 700
IRRPGLNQAI LLDAGGASGG GGEGKAFPWE HAKRLIQSGE VGSEGHVPLP
710 720 730 740 750
VILAGGLTPE NVGQAIEQAG EGVWCVDVSS GVEGEGGKVK EKVEAFVKAV

RG
Length:752
Mass (Da):80,277
Last modified:March 8, 2011 - v1
Checksum:iBEF5D889B167F5FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000293 Genomic DNA Translation: ADV23803.1
RefSeqiXP_003195590.1, XM_003195542.1

Genome annotation databases

EnsemblFungiiADV23803; ADV23803; CGB_H1160W
GeneIDi10189403
KEGGicgi:CGB_H1160W

Similar proteinsi

Entry informationi

Entry nameiE6RAF0_CRYGW
AccessioniPrimary (citable) accession number: E6RAF0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: June 20, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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