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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei226By similarity1
Active sitei446By similarity1
Active sitei503By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:CGB_E0630W
OrganismiCryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
Taxonomic identifieri367775 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus gattii species complex
Proteomesi
  • UP000007805 Componenti: Chromosome E

Organism-specific databases

EuPathDBiFungiDB:CGB_E0630W

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini? – 573LumenalSequence analysis
Transmembranei574 – 594HelicalSequence analysisAdd BLAST21
Topological domaini595 – 687CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000411918? – 687Pheromone-processing carboxypeptidase KEX1
Signal peptidei1 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiE6R6G5

Interactioni

Protein-protein interaction databases

STRINGi367775.XP_003194073.1

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 35Poly-Ser6

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
KOiK01288
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E6R6G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGNDARARV RSLPSTSSPL ETRDSDEQES SSSQSQRGSR KRGPQRRATE
60 70 80 90 100
LPSAADLYVP SLPGLPDMAT HPTHPLNIYA GMLPSYPGEG KVGGEGETGK
110 120 130 140 150
DAKLYFLMAK ARRNAGKERV IFWFNGGPGC SSFDGSLMEV GPFRTVPASE
160 170 180 190 200
TTTGMVEAKL VEGGWEEFAT VVFVDQPPGT GYSYAATNGY LHDFDELSAH
210 220 230 240 250
FIEFLQNFYT VFPELKGVDT YLAGESFAGQ YIPFFADALI NSAELPNFPL
260 270 280 290 300
KGIAIGNGWI DPKEQYPGYV EFAYEKGLID SGTPVSAAFV DLHKERADQM
310 320 330 340 350
LTDQEAEEME AALKRCQEEM DKYTDPFTTP VNIDHCGEVM DSVTRPFTQE
360 370 380 390 400
LNGKKVCMNV YDVRLVDDFP ACGMNWPPDL PDVYTFLRQD EVISALHASS
410 420 430 440 450
KETAWVECNN KVSYELNLKH SHMSAALLPS ILEAGVPILM FAGAEDLICN
460 470 480 490 500
YKGIERIVNG LEWGGEKGFA NATSQEWYLN GTQVGTWQTS RGLSYAKIFD
510 520 530 540 550
SSHMVGFDVP HVTNDMIMRF MDVDVSLLPG MISQWSSRIG DDERTMIHVG
560 570 580 590 600
DAGEAGGVPL IKGGNTDWEA WYNAVFAFLV LGILVSIVGL YFYFRRKPVS
610 620 630 640 650
YRSRIALKQR GRHRQSHDRD EGDTAERMPL GSERLELDDI ERAEGYEFDD
660 670 680
RDDEGYSGKG KGKGKELADD REEVMFALGD DDEDDRH
Length:687
Mass (Da):76,275
Last modified:March 8, 2011 - v1
Checksum:iF6E945C8D8CB3B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000290 Genomic DNA Translation: ADV22286.1
RefSeqiXP_003194073.1, XM_003194025.1

Genome annotation databases

EnsemblFungiiADV22286; ADV22286; CGB_E0630W
GeneIDi10190080
KEGGicgi:CGB_E0630W

Similar proteinsi

Entry informationi

Entry nameiKEX1_CRYGW
AccessioniPrimary (citable) accession number: E6R6G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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