Interleukin-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: UniProtKB-UniRule
• interleukin-1 receptor antagonist activity Source: InterPro
• interleukin-1 receptor binding Source: UniProtKB-UniRule

GO - Biological processⁱ

• cellular response to lipopolysaccharide Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cytokine-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• defense response to bacterium Source: ZFIN <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Host immune response and acute disease in a zebrafish model of Francisella pathogenesis."
    Vojtech L.N., Sanders G.E., Conway C., Ostland V., Hansen J.D.
    Infect Immun 77:914-925(2009) [PubMed] [Europe PMC] [Abstract]
• fin regeneration Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Transient inflammatory response mediated by interleukin-1beta is required for proper regeneration in zebrafish fin fold."
    Hasegawa T., Hall C.J., Crosier P.S., Abe G., Kawakami K., Kudo A., Kawakami A.
    Elife 6:0-0(2017) [PubMed] [Europe PMC] [Abstract]
• immune response Source: ZFINInferred from direct assayⁱ
  • "Pathogenesis and inflammatory response to Edwardsiella tarda infection in the zebrafish."
    Pressley M.E., Phelan P.E., Witten P.E., Mellon M.T., Kim C.H.
    Dev Comp Immunol 29:501-513(2005) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• macrophage chemotaxis Source: ZFINInferred from mutant phenotypeⁱ
  • "Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response."
    Ogryzko N.V., Hoggett E.E., Solaymani-Kohal S., Tazzyman S., Chico T.J., Renshaw S.A., Wilson H.L.
    Dis Model Mech 7:259-264(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of interleukin-1-mediated signaling pathway Source: InterPro
• neutrophil activation Source: ZFINInferred from mutant phenotypeⁱ
  • "Transient infection of the zebrafish notochord with E. coli induces chronic inflammation."
    Nguyen-Chi M., Phan Q.T., Gonzalez C., Dubremetz J.F., Levraud J.P., Lutfalla G.
    Dis Model Mech 7:871-882(2014) [PubMed] [Europe PMC] [Abstract]
• neutrophil chemotaxis Source: ZFINInferred from mutant phenotypeⁱ
  • "IL-1beta and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model."
    Yan B., Han P., Pan L., Lu W., Xiong J., Zhang M., Zhang W., Li L., Wen Z.
    J Immunol 192:5998-6008(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of NIK/NF-kappaB signaling Source: ZFINInferred from direct assayⁱ
  • "Discovery of the DIGIRR gene from teleost fish: a novel Toll-IL-1 receptor family member serving as a negative regulator of IL-1 signaling."
    Gu Y.F., Fang Y., Jin Y., Dong W.R., Xiang L.X., Shao J.Z.
    J Immunol 187:2514-2530(2011) [PubMed] [Europe PMC] [Abstract]
• response to arsenic-containing substance Source: ZFINInferred from direct assayⁱ
  • "Effects of low concentrations of arsenic on the innate immune system of the zebrafish (Danio rerio)."
    Nayak A.S., Lage C.R., Kim C.H.
    Toxicol Sci 98:118-124(2007) [PubMed] [Europe PMC] [Abstract]
• response to bacterium Source: ZFINInferred from direct assayⁱ
  • "Effects of low concentrations of arsenic on the innate immune system of the zebrafish (Danio rerio)."
    Nayak A.S., Lage C.R., Kim C.H.
    Toxicol Sci 98:118-124(2007) [PubMed] [Europe PMC] [Abstract]
  • "Innate immune gene expression in individual zebrafish after Listonella anguillarum inoculation."
    Rojo I., de Ilarduya O.M., Estonba A., Pardo M.A.
    Fish Shellfish Immunol 23:1285-1293(2007) [PubMed] [Europe PMC] [Abstract]
• response to exogenous dsRNA Source: ZFINInferred from direct assayⁱ
  • "Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation."
    Sepulcre M.P., Alcaraz-Perez F., Lopez-Munoz A., Roca F.J., Meseguer J., Cayuela M.L., Mulero V.
    J Immunol 182:1836-1845(2009) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: ZFINInferred from direct assayⁱ
  • "Bacterial lipopolysaccharides induce genes involved in the innate immune response in embryos of the zebrafish (Danio rerio)."
    Watzke J., Schirmer K., Scholz S.
    Fish Shellfish Immunol 23:901-905(2007) [PubMed] [Europe PMC] [Abstract]
  • "Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation."
    Sepulcre M.P., Alcaraz-Perez F., Lopez-Munoz A., Roca F.J., Meseguer J., Cayuela M.L., Mulero V.
    J Immunol 182:1836-1845(2009) [PubMed] [Europe PMC] [Abstract]
• response to molecule of bacterial origin Source: ZFINInferred from direct assayⁱ
  • "Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation."
    Sepulcre M.P., Alcaraz-Perez F., Lopez-Munoz A., Roca F.J., Meseguer J., Cayuela M.L., Mulero V.
    J Immunol 182:1836-1845(2009) [PubMed] [Europe PMC] [Abstract]
• response to virus Source: ZFINInferred from direct assayⁱ
  • "Mortality Caused by Bath Exposure of Zebrafish (Danio rerio) Larvae to Nervous Necrosis Virus Is Limited to the Fourth Day Postfertilization."
    Morick D., Faigenbaum O., Smirnov M., Fellig Y., Inbal A., Kotler M.
    Appl Environ Microbiol 81:3280-3287(2015) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• cytokine activity Source: UniProtKB-UniRule
• interleukin-1 receptor antagonist activity Source: InterPro
• interleukin-1 receptor binding Source: UniProtKB-UniRule

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MACGQYEVTI APKNLWETDG AVYSDSDEMD CSDPLAMSYR CDMHEGIRLE 
        60         70         80         90        100
MWTSQHKMKQ LVNVIIALNR MKHIKPQSTE FGEKEVLDML MANVIQEREV 
       110        120        130        140        150
NVVDSVPSYT KTKNVLQCTI CDQYKKSLVR SGGSPHLQAV TLRAGSSDLK 
       160        170        180        190        200
VRFSMSTYAS PSAPATSAQP VCLGISKSNL YLACSPAEGS APHLVLKEIS 
       210        220        230        240        250
GSLETIKAGD PNGYDQLLFF RKETGSSINT FESVKCPGWF ISTAYEDSQM 
       260        270 
VEMDRKDTER IINFELQDKV RI                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ