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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Enterococcus faecalis TX0309B
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158L-tryptophanUniRule annotation1
Binding sitei213ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 35ATPUniRule annotation3
Nucleotide bindingi41 – 42ATPUniRule annotation2
Nucleotide bindingi170 – 172ATPUniRule annotation3
Nucleotide bindingi222 – 226ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotation, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotationImported
ORF Names:HMPREF9507_02527Imported
OrganismiEnterococcus faecalis TX0309BImported
Taxonomic identifieri749504 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000005187 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42"HIGH" regionUniRule annotation9
Motifi222 – 226"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

E6H6L8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYFFLIKCII ELFTILSLKS GGYLMKTIFS GIQPSGTPTI GNYIGAMKQF
60 70 80 90 100
IELQNEYNCY FCIVDEHAIT VPQEPQKLRQ QIRSLAALYL AVGLDPQKAT
110 120 130 140 150
IFIQSEVSAH AEAGWIIQCN TSIGELERMT QFKDKSQKNG RAGVSAGLLT
160 170 180 190 200
YPPLMVGDIV LYNADLVPVG DDQKQHLELT RDFVERFNKR YAQKNQEILT
210 220 230 240 250
IPEVKIAEQG SRIMSLQEPT KKMSKSDTNV KGFISMLDEP AVIRKKIRSA
260 270 280 290 300
VTDSTGVIEY NKEEKPGITN LLNIYSAATG QTVEELVQAY EGKGYGDFKA
310 320 330 340 350
DLAEAVVALL EPIQVRYQEL LASEELDMIL DEGAENARLV ANKTLQRMKN
360
AVGLGRKVRR
Length:360
Mass (Da):40,241
Last modified:March 8, 2011 - v1
Checksum:i4CE00B6F9F4212F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEBO01000060 Genomic DNA Translation: EFU86043.1

Genome annotation databases

EnsemblBacteriaiEFU86043; EFU86043; HMPREF9507_02527
PATRICifig|749504.3.peg.2362

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEBO01000060 Genomic DNA Translation: EFU86043.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEFU86043; EFU86043; HMPREF9507_02527
PATRICifig|749504.3.peg.2362

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE6H6L8_ENTFL
AccessioniPrimary (citable) accession number: E6H6L8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 7, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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