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Entry version 47 (02 Jun 2021)
Sequence version 1 (08 Mar 2011)
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Protein

Innexin

Gene

unc-9

Organism
Trichinella spiralis (Trichina worm)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural component of the gap junctions.

UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channelUniRule annotation
Biological processIon transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.25.1.12, the gap junction-forming innexin (innexin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
InnexinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-9Imported
Synonyms:inxUniRule annotation
ORF Names:T01_2939Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrichinella spiralis (Trichina worm)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6334 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaEnopleaDorylaimiaTrichinellidaTrichinellidaeTrichinella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000054776 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei112 – 134HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei194 – 217HelicalPROSITE-ProRule annotationAdd BLAST24
Transmembranei286 – 310HelicalPROSITE-ProRule annotationAdd BLAST25
Transmembranei503 – 524HelicalPROSITE-ProRule annotationAdd BLAST22
Transmembranei588 – 614HelicalPROSITE-ProRule annotationAdd BLAST27
Transmembranei679 – 703HelicalPROSITE-ProRule annotationAdd BLAST25

Keywords - Cellular componenti

Cell junction, Gap junctionPROSITE-ProRule annotationARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni781 – 813DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi781 – 798Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWRS, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_347287_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FRICTIC

Database of Orthologous Groups

More...
OrthoDBi
738314at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000990, Innexin

The PANTHER Classification System

More...
PANTHERi
PTHR11893, PTHR11893, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00876, Innexin, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01262, INNEXIN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51013, PANNEXIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E5SKQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKLTQYLSS IKPYRDCDFI DRLNSFYTVI GTVCFAVLVS GWSFVGTPIQ
60 70 80 90 100
CWFPAYFKGW WIQYSLDYCY VQNTYFLPFT KSVPLKNYWD LIRSPIDIPE
110 120 130 140 150
SVEKREERLI GYYQWVPFIL ALVAVCFWMP MAFWRALNMH SGISVKTVCD
160 170 180 190 200
MTSIVEHVEP LSRRKNVDKI AQLLDHSTVL SARLHGRNLF TGRYILLLYL
210 220 230 240 250
AVKIYYVINA VMLFFMLQHF LGVDDSFWGA RVFYNLVYGR QWEETGNFPR
260 270 280 290 300
VTICDFEVRE LGNVHRHSVQ CVLMINMFNE KIFLFFWWWF VILAVLNSIN
310 320 330 340 350
LLCWIASIIF DSFSWSYVIS YLQDSDQWEM SESEFLLNIE NFVKTCLQPD
360 370 380 390 400
GMFLLRLIGT NSGEIVSKEL VNSLWNRYLS RKISNHKKMD DDQSLLDFGT
410 420 430 440 450
TATMFFVDSF LRALTPHNDD DLVDRVNYYY TPIIIAFFSL TLSAKQYVGQ
460 470 480 490 500
PIQCWVPAQF TGAWEQYTEN YCFVQNTYFL QLTNQIPVDY VERDSREIGY
510 520 530 540 550
YQWVPFILAL QAFLFYLPCL IWRLTNWYSG ISVLGITNMA VDAGNMDHET
560 570 580 590 600
RKKNVKTVAQ HIRQSLNLQR ELSTSGKLFG FLIYGKHYGI YVTGLYLFIK
610 620 630 640 650
FLYILNVVCQ FLILNRFLGA QYTFWGFEIL RDLAYGREWQ ESGHFPRVTM
660 670 680 690 700
CDFDVRVLGN LHRWTVQCVL MINMFNEKIY LFLWWWFFII SIFTFLNFFY
710 720 730 740 750
WIFVSFNENM QVNFISRYLR VSDKISDTLP EQRRVGKFVR RELRPDGVFL
760 770 780 790 800
LRIIASNAGD IIATELIKSL WTVYDAKQNH PTPPPVQSKK NMNYDKNDQS
810
PYQEEKMPLA GSQ
Length:813
Mass (Da):96,130
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF36064FE6C17AB69
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0V1BCD9A0A0V1BCD9_TRISP
Innexin
unc-9 inx, T01_2939
852Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JYDH01000062 Genomic DNA Translation: KRY34730.1

NCBI Reference Sequences

More...
RefSeqi
XP_003373184.1, XM_003373136.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
EFV54644; EFV54644; EFV54644

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10905512

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tsp:Tsp_10030

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JYDH01000062 Genomic DNA Translation: KRY34730.1
RefSeqiXP_003373184.1, XM_003373136.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.25.1.12, the gap junction-forming innexin (innexin) family

Genome annotation databases

EnsemblMetazoaiEFV54644; EFV54644; EFV54644
GeneIDi10905512
KEGGitsp:Tsp_10030

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10905512

Phylogenomic databases

eggNOGiENOG502QWRS, Eukaryota
HOGENOMiCLU_347287_0_0_1
OMAiFRICTIC
OrthoDBi738314at2759

Family and domain databases

InterProiView protein in InterPro
IPR000990, Innexin
PANTHERiPTHR11893, PTHR11893, 2 hits
PfamiView protein in Pfam
PF00876, Innexin, 2 hits
PRINTSiPR01262, INNEXIN
PROSITEiView protein in PROSITE
PS51013, PANNEXIN, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5SKQ0_TRISP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5SKQ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: June 2, 2021
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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