UniProtKB - E5RK62 (E5RK62_HUMAN)
Protein
Osteonectin
Gene
SPARC
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calcium ion binding Source: InterPro
- collagen binding Source: InterPro
Keywordsi
Ligand | CopperARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: OsteonectinARBA annotationAlternative name(s): SPARCARBA annotation Secreted protein acidic and rich in cysteineARBA annotation |
Gene namesi | Name:SPARCImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11219, SPARC |
VEuPathDBi | HostDB:ENSG00000113140.10 |
Subcellular locationi
Extracellular region or secreted
- basement membrane ARBA annotation
Other locations
- Membrane ARBA annotation
Extracellular region or secreted
- basement membrane Source: UniProtKB-SubCell
- extracellular space Source: InterPro
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Basement membraneARBA annotation, Extracellular matrix, SecretedPTM / Processingi
Keywords - PTMi
GlycoproteinARBA annotationProteomic databases
MaxQBi | E5RK62 |
PeptideAtlasi | E5RK62 |
PRIDEi | E5RK62 |
ProteomicsDBi | 16815 |
Expressioni
Gene expression databases
Bgeei | ENSG00000113140, Expressed in tibia and 242 other tissues |
ExpressionAtlasi | E5RK62, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 60 | Kazal-likeInterPro annotationAdd BLAST | 58 |
Keywords - Domaini
SignalARBA annotationPhylogenomic databases
GeneTreei | ENSGT00510000046787 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR001999, Osteonectin_CS IPR037641, SPARC IPR019577, SPARC/Testican_Ca-bd-dom |
PANTHERi | PTHR13866:SF6, PTHR13866:SF6, 1 hit |
Pfami | View protein in Pfam PF00050, Kazal_1, 1 hit PF10591, SPARC_Ca_bdg, 1 hit |
SMARTi | View protein in SMART SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS51465, KAZAL_2, 1 hit PS00613, OSTEONECTIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
E5RK62-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCVCQDPTSC PAPIGEFEKV CSNDNKTFDS SCHFFATKCT LEGTKKGHKL
60 70 80 90 100
HLDYIGPCKY IPPCLDSELT EFPLRMRDWL KNVLVTLYER DEDNNLLTEK
110
QKLRVKKIHE NEKRL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP09486 | SPRC_HUMAN | SPARC | SPARC ON | 303 | Annotation score: | ||
F5GY03 | F5GY03_HUMAN | Osteonectin | SPARC | 149 | Annotation score: | ||
F5H4E2 | F5H4E2_HUMAN | SPARC | SPARC | 111 | Annotation score: | ||
E5RJA5 | E5RJA5_HUMAN | SPARC | SPARC | 53 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 115 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011374 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000521569; ENSP00000428119; ENSG00000113140 |
UCSCi | uc063ivt.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011374 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | E5RK62 |
PeptideAtlasi | E5RK62 |
PRIDEi | E5RK62 |
ProteomicsDBi | 16815 |
Protocols and materials databases
Antibodypediai | 878, 758 antibodies |
Genome annotation databases
Ensembli | ENST00000521569; ENSP00000428119; ENSG00000113140 |
UCSCi | uc063ivt.1, human |
Organism-specific databases
HGNCi | HGNC:11219, SPARC |
OpenTargetsi | ENSG00000113140 |
VEuPathDBi | HostDB:ENSG00000113140.10 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00510000046787 |
Miscellaneous databases
ChiTaRSi | SPARC, human |
Gene expression databases
Bgeei | ENSG00000113140, Expressed in tibia and 242 other tissues |
ExpressionAtlasi | E5RK62, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR001999, Osteonectin_CS IPR037641, SPARC IPR019577, SPARC/Testican_Ca-bd-dom |
PANTHERi | PTHR13866:SF6, PTHR13866:SF6, 1 hit |
Pfami | View protein in Pfam PF00050, Kazal_1, 1 hit PF10591, SPARC_Ca_bdg, 1 hit |
SMARTi | View protein in SMART SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS51465, KAZAL_2, 1 hit PS00613, OSTEONECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E5RK62_HUMAN | |
Accessioni | E5RK62Primary (citable) accession number: E5RK62 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | February 10, 2021 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |