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Protein
Submitted name:

Heat shock factor protein 4

Gene

HSF4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Heat shock factor protein 4Imported
Gene namesi
Name:HSF4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000102878.16
HGNCiHGNC:5227 HSF4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000102878

PTM / Processingi

Proteomic databases

MaxQBiE5RK26
PeptideAtlasiE5RK26
PRIDEiE5RK26

Expressioni

Gene expression databases

BgeeiENSG00000102878 Expressed in 155 organ(s), highest expression level in lower esophagus muscularis layer
ExpressionAtlasiE5RK26 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE5RK26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 83HSF_DOMAINInterPro annotationAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili143 – 163Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the HSF family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000001182

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000232 HSF_DNA-bd
IPR027725 HSF_fam
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10015 PTHR10015, 2 hits
PfamiView protein in Pfam
PF00447 HSF_DNA-bind, 1 hit
PRINTSiPR00056 HSFDOMAIN
SMARTiView protein in SMART
SM00415 HSF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00434 HSF_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

E5RK26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEAPAALPT EPGPSPVPAF LGKLWALVGD PGTDHLIRWS PSGTSFLVSD
60 70 80 90 100
QSRFAKEVLP QYFKHSNMAS FVRQLNMYGF RKVVSIEQGG LLRPERDHVE
110 120 130 140 150
FQHPSFVRGR EQLLERVRRK VPALRGDDGR WRPEDLGRLL GEVQALRGVQ
160 170 180 190 200
ESTEARLREL RQQNEILWRE VVTLRQSHGQ QHRVIGKLIQ CLFGPLQAGP
210 220 230 240 250
SNAGGKRKLS LMLDEGSSCP TPAKFNTCPL PGALLQDPYF IQSPLPETNL
260 270 280 290 300
GLSPHRARGP IISDIPEDSP SPEGTRLSPS SDGRRGPLGL ESGDRSPESL
310 320 330 340 350
LPPMLLQPPQ ESVEPAGPLD VLGPSLQGRE WTLMDLDMEL SLMQPLVPER
360 370 380 390 400
GEPELAVKGL NSPSPGKDPT LGAPLLLDVQ AALGGPALGL PGALTIYSTP
410
ESRTASYLGP EASPSP
Length:416
Mass (Da):45,230
Last modified:February 8, 2011 - v1
Checksum:iDE2C848CFE89CCC2
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9ULV5HSF4_HUMAN
Heat shock factor protein 4
HSF4
492Annotation score:
E5RJV4E5RJV4_HUMAN
Heat shock factor protein 4
HSF4
318Annotation score:
E7EWW4E7EWW4_HUMAN
Heat shock factor protein 4
HSF4
315Annotation score:
E5RG51E5RG51_HUMAN
Heat shock factor protein 4
HSF4
194Annotation score:
H0YBT7H0YBT7_HUMAN
Heat shock factor protein 4
HSF4
185Annotation score:
H0YC39H0YC39_HUMAN
Heat shock factor protein 4
HSF4
141Annotation score:
H0YAU2H0YAU2_HUMAN
Heat shock factor protein 4
HSF4
223Annotation score:
E5RHY0E5RHY0_HUMAN
Heat shock factor protein 4
HSF4
47Annotation score:
H0YBS6H0YBS6_HUMAN
Heat shock factor protein 4
HSF4
182Annotation score:
H0YBG9H0YBG9_HUMAN
Heat shock factor protein 4
HSF4
63Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei416Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC074143 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000517685; ENSP00000428978; ENSG00000102878
UCSCiuc059vox.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC074143 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE5RK26
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE5RK26
PeptideAtlasiE5RK26
PRIDEiE5RK26

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000517685; ENSP00000428978; ENSG00000102878
UCSCiuc059vox.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000102878.16
HGNCiHGNC:5227 HSF4
OpenTargetsiENSG00000102878
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000001182

Gene expression databases

BgeeiENSG00000102878 Expressed in 155 organ(s), highest expression level in lower esophagus muscularis layer
ExpressionAtlasiE5RK26 baseline and differential

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000232 HSF_DNA-bd
IPR027725 HSF_fam
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10015 PTHR10015, 2 hits
PfamiView protein in Pfam
PF00447 HSF_DNA-bind, 1 hit
PRINTSiPR00056 HSFDOMAIN
SMARTiView protein in SMART
SM00415 HSF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00434 HSF_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE5RK26_HUMAN
AccessioniPrimary (citable) accession number: E5RK26
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 12, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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