UniProtKB - E5RJM6 (ANR65_HUMAN)
Protein
Ankyrin repeat domain-containing protein 65
Gene
ANKRD65
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin repeat domain-containing protein 65 |
Gene namesi | Name:ANKRD65 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000235098.8 |
HGNCi | HGNC:42950 ANKRD65 |
neXtProti | NX_E5RJM6 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000235098 |
Polymorphism and mutation databases
BioMutai | ANKRD65 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000414484 | 1 – 399 | Ankyrin repeat domain-containing protein 65Add BLAST | 399 |
Proteomic databases
PaxDbi | E5RJM6 |
PRIDEi | E5RJM6 |
ProteomicsDBi | 16650 16651 [E5RJM6-2] |
PTM databases
PhosphoSitePlusi | E5RJM6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000235098 Expressed in 131 organ(s), highest expression level in right uterine tube |
Genevisiblei | E5RJM6 HS |
Organism-specific databases
HPAi | HPA065720 |
Interactioni
Protein-protein interaction databases
BioGridi | 137829, 1 interactor |
STRINGi | 9606.ENSP00000445688 |
Structurei
3D structure databases
ProteinModelPortali | E5RJM6 |
SMRi | E5RJM6 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 40 – 69 | ANK 1Add BLAST | 30 | |
Repeati | 73 – 102 | ANK 2Add BLAST | 30 | |
Repeati | 106 – 135 | ANK 3Add BLAST | 30 | |
Repeati | 139 – 168 | ANK 4Add BLAST | 30 | |
Repeati | 176 – 205 | ANK 5Add BLAST | 30 | |
Repeati | 207 – 231 | ANK 6Add BLAST | 25 | |
Repeati | 235 – 264 | ANK 7Add BLAST | 30 | |
Repeati | 268 – 297 | ANK 8Add BLAST | 30 | |
Repeati | 301 – 330 | ANK 9Add BLAST | 30 | |
Repeati | 334 – 363 | ANK 10Add BLAST | 30 |
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG4177 Eukaryota COG0666 LUCA |
GeneTreei | ENSGT00940000163707 |
InParanoidi | E5RJM6 |
OMAi | QWAEVAQ |
OrthoDBi | 812341at2759 |
PhylomeDBi | E5RJM6 |
TreeFami | TF329520 |
Family and domain databases
CDDi | cd00204 ANK, 3 hits |
Gene3Di | 1.25.40.20, 4 hits |
InterProi | View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796 Ank_2, 2 hits |
PRINTSi | PR01415 ANKYRIN |
SMARTi | View protein in SMART SM00248 ANK, 9 hits |
SUPFAMi | SSF48403 SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 7 hits |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: E5RJM6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDSQRPEPRE EEEEEQELRW MELDSEEALG TRTEGPSVVQ GWGHLLQAVW
60 70 80 90 100
RGPAGLVTQL LRQGASVEER DHAGRTPLHL AVLRGHAPLV RLLLQRGAPV
110 120 130 140 150
GAVDRAGRTA LHEAAWHGHS RVAELLLQRG ASAAARSGTG LTPLHWAAAL
160 170 180 190 200
GHTLLAARLL EAPGPGPAAA EAEDARGWTA AHWAAAGGRL AVLELLAAGG
210 220 230 240 250
AGLDGALLVA AAAGRGAALR FLLARGARVD ARDGAGATAL GLAAALGRSQ
260 270 280 290 300
DIEVLLGHGA DPGIRDRHGR SALHRAAARG HLLAVQLLVT QGAEVDARDT
310 320 330 340 350
LGLTPLHHAS REGHVEVAGC LLDRGAQVDA TGWLRKTPLH LAAERGHGPT
360 370 380 390
VGLLLSRGAS PTLRTQWAEV AQMPEGDLPQ ALPELGGGEK ECEGIESTG
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045962 | 65 | A → H in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_045963 | 66 – 399 | Missing in isoform 3. 1 PublicationAdd BLAST | 334 | |
Alternative sequenceiVSP_042085 | 71 – 173 | DHAGR…AAEAE → TLRCCWATGQTQASGTGMAA LRCTGLPPEDTCLPSSCWSP RGPRWMRGTPWASHPCITPL GKATWRLPAACWTGVPRWML PAGSERPPYTWLQSEGMGLP WGFC in isoform 2. 1 PublicationAdd BLAST | 103 | |
Alternative sequenceiVSP_042086 | 174 – 399 | Missing in isoform 2. 1 PublicationAdd BLAST | 226 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL391244 Genomic DNA No translation available. BC063445 mRNA No translation available. BC094869 mRNA No translation available. AI522076 mRNA No translation available. |
CCDSi | CCDS55558.1 [E5RJM6-1] CCDS57962.1 [E5RJM6-2] CCDS57963.1 [E5RJM6-3] |
RefSeqi | NP_001138682.1, NM_001145210.2 [E5RJM6-1] NP_001230464.1, NM_001243535.1 [E5RJM6-2] NP_001230465.1, NM_001243536.1 [E5RJM6-3] XP_005244809.1, XM_005244752.4 [E5RJM6-1] XP_006710710.1, XM_006710647.3 [E5RJM6-1] XP_011539791.1, XM_011541489.2 [E5RJM6-1] XP_016856813.1, XM_017001324.1 [E5RJM6-1] XP_016856814.1, XM_017001325.1 [E5RJM6-2] XP_016856815.1, XM_017001326.1 [E5RJM6-3] |
UniGenei | Hs.381222 |
Genome annotation databases
Ensembli | ENST00000427211; ENSP00000428419; ENSG00000235098 [E5RJM6-2] ENST00000442470; ENSP00000428201; ENSG00000235098 [E5RJM6-2] ENST00000454272; ENSP00000482314; ENSG00000235098 [E5RJM6-1] ENST00000520296; ENSP00000429035; ENSG00000235098 [E5RJM6-3] ENST00000537107; ENSP00000445688; ENSG00000235098 [E5RJM6-1] |
GeneIDi | 441869 |
KEGGi | hsa:441869 |
UCSCi | uc001afp.3 human [E5RJM6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL391244 Genomic DNA No translation available. BC063445 mRNA No translation available. BC094869 mRNA No translation available. AI522076 mRNA No translation available. |
CCDSi | CCDS55558.1 [E5RJM6-1] CCDS57962.1 [E5RJM6-2] CCDS57963.1 [E5RJM6-3] |
RefSeqi | NP_001138682.1, NM_001145210.2 [E5RJM6-1] NP_001230464.1, NM_001243535.1 [E5RJM6-2] NP_001230465.1, NM_001243536.1 [E5RJM6-3] XP_005244809.1, XM_005244752.4 [E5RJM6-1] XP_006710710.1, XM_006710647.3 [E5RJM6-1] XP_011539791.1, XM_011541489.2 [E5RJM6-1] XP_016856813.1, XM_017001324.1 [E5RJM6-1] XP_016856814.1, XM_017001325.1 [E5RJM6-2] XP_016856815.1, XM_017001326.1 [E5RJM6-3] |
UniGenei | Hs.381222 |
3D structure databases
ProteinModelPortali | E5RJM6 |
SMRi | E5RJM6 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 137829, 1 interactor |
STRINGi | 9606.ENSP00000445688 |
PTM databases
PhosphoSitePlusi | E5RJM6 |
Polymorphism and mutation databases
BioMutai | ANKRD65 |
Proteomic databases
PaxDbi | E5RJM6 |
PRIDEi | E5RJM6 |
ProteomicsDBi | 16650 16651 [E5RJM6-2] |
Protocols and materials databases
DNASUi | 441869 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000427211; ENSP00000428419; ENSG00000235098 [E5RJM6-2] ENST00000442470; ENSP00000428201; ENSG00000235098 [E5RJM6-2] ENST00000454272; ENSP00000482314; ENSG00000235098 [E5RJM6-1] ENST00000520296; ENSP00000429035; ENSG00000235098 [E5RJM6-3] ENST00000537107; ENSP00000445688; ENSG00000235098 [E5RJM6-1] |
GeneIDi | 441869 |
KEGGi | hsa:441869 |
UCSCi | uc001afp.3 human [E5RJM6-1] |
Organism-specific databases
CTDi | 441869 |
EuPathDBi | HostDB:ENSG00000235098.8 |
GeneCardsi | ANKRD65 |
HGNCi | HGNC:42950 ANKRD65 |
HPAi | HPA065720 |
neXtProti | NX_E5RJM6 |
OpenTargetsi | ENSG00000235098 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4177 Eukaryota COG0666 LUCA |
GeneTreei | ENSGT00940000163707 |
InParanoidi | E5RJM6 |
OMAi | QWAEVAQ |
OrthoDBi | 812341at2759 |
PhylomeDBi | E5RJM6 |
TreeFami | TF329520 |
Miscellaneous databases
ChiTaRSi | ANKRD65 human |
GenomeRNAii | 441869 |
PROi | PR:E5RJM6 |
Gene expression databases
Bgeei | ENSG00000235098 Expressed in 131 organ(s), highest expression level in right uterine tube |
Genevisiblei | E5RJM6 HS |
Family and domain databases
CDDi | cd00204 ANK, 3 hits |
Gene3Di | 1.25.40.20, 4 hits |
InterProi | View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796 Ank_2, 2 hits |
PRINTSi | PR01415 ANKYRIN |
SMARTi | View protein in SMART SM00248 ANK, 9 hits |
SUPFAMi | SSF48403 SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 7 hits |
ProtoNeti | Search... |
Entry informationi
Entry namei | ANR65_HUMAN | |
Accessioni | E5RJM6Primary (citable) accession number: E5RJM6 Secondary accession number(s): J3KR93 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 14, 2011 |
Last sequence update: | December 14, 2011 | |
Last modified: | January 16, 2019 | |
This is version 64 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM