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UniProtKB - E5RJM6 (ANR65_HUMAN)

Entry version 64 (16 Jan 2019)
Sequence version 2 (14 Dec 2011)
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Protein

Ankyrin repeat domain-containing protein 65

Gene

ANKRD65

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 65
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD65
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000235098.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:42950 ANKRD65

neXtProt; the human protein knowledge platform

More...neXtProti		NX_E5RJM6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000235098

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ANKRD65

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004144841 – 399Ankyrin repeat domain-containing protein 65Add BLAST399

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E5RJM6

PRoteomics IDEntifications database

More...PRIDEi		E5RJM6

ProteomicsDB human proteome resource

More...ProteomicsDBi		16650
16651 [E5RJM6-2]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		E5RJM6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000235098 Expressed in 131 organ(s), highest expression level in right uterine tube

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		E5RJM6 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA065720

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		137829, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000445688

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		E5RJM6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E5RJM6

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati40 – 69ANK 1Add BLAST30
Repeati73 – 102ANK 2Add BLAST30
Repeati106 – 135ANK 3Add BLAST30
Repeati139 – 168ANK 4Add BLAST30
Repeati176 – 205ANK 5Add BLAST30
Repeati207 – 231ANK 6Add BLAST25
Repeati235 – 264ANK 7Add BLAST30
Repeati268 – 297ANK 8Add BLAST30
Repeati301 – 330ANK 9Add BLAST30
Repeati334 – 363ANK 10Add BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163707

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E5RJM6

Identification of Orthologs from Complete Genome Data

More...OMAi		QWAEVAQ

Database of Orthologous Groups

More...OrthoDBi		812341at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		E5RJM6

TreeFam database of animal gene trees

More...TreeFami		TF329520

Family and domain databases

Conserved Domains Database

More...CDDi		cd00204 ANK, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796 Ank_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248 ANK, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: E5RJM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSQRPEPRE EEEEEQELRW MELDSEEALG TRTEGPSVVQ GWGHLLQAVW 
        60         70         80         90        100
RGPAGLVTQL LRQGASVEER DHAGRTPLHL AVLRGHAPLV RLLLQRGAPV 
       110        120        130        140        150
GAVDRAGRTA LHEAAWHGHS RVAELLLQRG ASAAARSGTG LTPLHWAAAL 
       160        170        180        190        200
GHTLLAARLL EAPGPGPAAA EAEDARGWTA AHWAAAGGRL AVLELLAAGG 
       210        220        230        240        250
AGLDGALLVA AAAGRGAALR FLLARGARVD ARDGAGATAL GLAAALGRSQ 
       260        270        280        290        300
DIEVLLGHGA DPGIRDRHGR SALHRAAARG HLLAVQLLVT QGAEVDARDT 
       310        320        330        340        350
LGLTPLHHAS REGHVEVAGC LLDRGAQVDA TGWLRKTPLH LAAERGHGPT 
       360        370        380        390 
VGLLLSRGAS PTLRTQWAEV AQMPEGDLPQ ALPELGGGEK ECEGIESTG
Length:399
Mass (Da):41,497
Last modified:December 14, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13AE59F52E54CF4A
GO
Isoform 2 (identifier: E5RJM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-173: DHAGRTPLHL...GPGPAAAEAE → TLRCCWATGQ...EGMGLPWGFC
     174-399: Missing.

Show »
Length:174
Mass (Da):19,375
Checksum:iD9F1F20E2157F6E8
GO
Isoform 3 (identifier: E5RJM6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-65: A → H
     66-399: Missing.

Note: No experimental confirmation available.
Show »
Length:65
Mass (Da):7,466
Checksum:i8A801D058E1262DA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04596265A → H in isoform 3. 1 Publication1
Alternative sequenceiVSP_04596366 – 399Missing in isoform 3. 1 PublicationAdd BLAST334
Alternative sequenceiVSP_04208571 – 173DHAGR…AAEAE → TLRCCWATGQTQASGTGMAA LRCTGLPPEDTCLPSSCWSP RGPRWMRGTPWASHPCITPL GKATWRLPAACWTGVPRWML PAGSERPPYTWLQSEGMGLP WGFC in isoform 2. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_042086174 – 399Missing in isoform 2. 1 PublicationAdd BLAST226

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL391244 Genomic DNA No translation available.
BC063445 mRNA No translation available.
BC094869 mRNA No translation available.
AI522076 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55558.1 [E5RJM6-1]
CCDS57962.1 [E5RJM6-2]
CCDS57963.1 [E5RJM6-3]

NCBI Reference Sequences

More...RefSeqi		NP_001138682.1, NM_001145210.2 [E5RJM6-1]
NP_001230464.1, NM_001243535.1 [E5RJM6-2]
NP_001230465.1, NM_001243536.1 [E5RJM6-3]
XP_005244809.1, XM_005244752.4 [E5RJM6-1]
XP_006710710.1, XM_006710647.3 [E5RJM6-1]
XP_011539791.1, XM_011541489.2 [E5RJM6-1]
XP_016856813.1, XM_017001324.1 [E5RJM6-1]
XP_016856814.1, XM_017001325.1 [E5RJM6-2]
XP_016856815.1, XM_017001326.1 [E5RJM6-3]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.381222

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000427211; ENSP00000428419; ENSG00000235098 [E5RJM6-2]
ENST00000442470; ENSP00000428201; ENSG00000235098 [E5RJM6-2]
ENST00000454272; ENSP00000482314; ENSG00000235098 [E5RJM6-1]
ENST00000520296; ENSP00000429035; ENSG00000235098 [E5RJM6-3]
ENST00000537107; ENSP00000445688; ENSG00000235098 [E5RJM6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		441869

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:441869

UCSC genome browser

More...UCSCi		uc001afp.3 human [E5RJM6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391244 Genomic DNA No translation available.
BC063445 mRNA No translation available.
BC094869 mRNA No translation available.
AI522076 mRNA No translation available.
CCDSiCCDS55558.1 [E5RJM6-1]
CCDS57962.1 [E5RJM6-2]
CCDS57963.1 [E5RJM6-3]
RefSeqiNP_001138682.1, NM_001145210.2 [E5RJM6-1]
NP_001230464.1, NM_001243535.1 [E5RJM6-2]
NP_001230465.1, NM_001243536.1 [E5RJM6-3]
XP_005244809.1, XM_005244752.4 [E5RJM6-1]
XP_006710710.1, XM_006710647.3 [E5RJM6-1]
XP_011539791.1, XM_011541489.2 [E5RJM6-1]
XP_016856813.1, XM_017001324.1 [E5RJM6-1]
XP_016856814.1, XM_017001325.1 [E5RJM6-2]
XP_016856815.1, XM_017001326.1 [E5RJM6-3]
UniGeneiHs.381222

3D structure databases

ProteinModelPortaliE5RJM6
SMRiE5RJM6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137829, 1 interactor
STRINGi9606.ENSP00000445688

PTM databases

PhosphoSitePlusiE5RJM6

Polymorphism and mutation databases

BioMutaiANKRD65

Proteomic databases

PaxDbiE5RJM6
PRIDEiE5RJM6
ProteomicsDBi16650
16651 [E5RJM6-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		441869
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427211; ENSP00000428419; ENSG00000235098 [E5RJM6-2]
ENST00000442470; ENSP00000428201; ENSG00000235098 [E5RJM6-2]
ENST00000454272; ENSP00000482314; ENSG00000235098 [E5RJM6-1]
ENST00000520296; ENSP00000429035; ENSG00000235098 [E5RJM6-3]
ENST00000537107; ENSP00000445688; ENSG00000235098 [E5RJM6-1]
GeneIDi441869
KEGGihsa:441869
UCSCiuc001afp.3 human [E5RJM6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		441869
EuPathDBiHostDB:ENSG00000235098.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		ANKRD65
HGNCiHGNC:42950 ANKRD65
HPAiHPA065720
neXtProtiNX_E5RJM6
OpenTargetsiENSG00000235098

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000163707
InParanoidiE5RJM6
OMAiQWAEVAQ
OrthoDBi812341at2759
PhylomeDBiE5RJM6
TreeFamiTF329520

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ANKRD65 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		441869

Protein Ontology

More...PROi		PR:E5RJM6

Gene expression databases

BgeeiENSG00000235098 Expressed in 131 organ(s), highest expression level in right uterine tube
GenevisibleiE5RJM6 HS

Family and domain databases

CDDicd00204 ANK, 3 hits
Gene3Di1.25.40.20, 4 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 9 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR65_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5RJM6
Secondary accession number(s): J3KR93
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: December 14, 2011
Last modified: January 16, 2019
This is version 64 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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