UniProtKB - E5RJF8 (E5RJF8_HUMAN)
Protein
Submitted name:
Centrin-3
Gene
CETN3
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
- G-protein beta/gamma-subunit complex binding Source: Ensembl
- microtubule binding Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Centrin-3Imported |
Gene namesi | Name:CETN3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000153140.8 |
HGNCi | HGNC:1868, CETN3 |
Subcellular locationi
Cytoskeleton
- centriole Source: Ensembl
- centrosome Source: HPA
- ciliary basal body Source: Ensembl
Other locations
- photoreceptor connecting cilium Source: Ensembl
PTM / Processingi
Proteomic databases
EPDi | E5RJF8 |
MaxQBi | E5RJF8 |
PeptideAtlasi | E5RJF8 |
PRIDEi | E5RJF8 |
ProteomicsDBi | 16586 |
Expressioni
Gene expression databases
Bgeei | ENSG00000153140, Expressed in testis and 247 other tissues |
ExpressionAtlasi | E5RJF8, baseline and differential |
Interactioni
GO - Molecular functioni
- microtubule binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9606.ENSP00000428259 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 60 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 61 – 96 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 98 – 133 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 134 – 154 | EF-handInterPro annotationAdd BLAST | 21 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 120 – 140 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG0028, Eukaryota |
GeneTreei | ENSGT00940000157995 |
OMAi | EFFAIMT |
OrthoDBi | 1340191at2759 |
PhylomeDBi | E5RJF8 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
E5RJF8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL
60 70 80 90 100
KVAMRALGFD VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH
110 120 130 140 150
EEILKAFKLF DDDDSGKISL RNLRRVAREL GENMSDEELR AMIEEFDKDG
160 170 180 190
DGEILKNILL LPIWSRCLSL NREFFSEVNQ EEFIAIMTGD I
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO15182 | CETN3_HUMAN | Centrin-3 | CETN3 CEN3 | 167 | Annotation score: | ||
E5RK82 | E5RK82_HUMAN | Centrin-3 | CETN3 | 156 | Annotation score: | ||
E5RFM2 | E5RFM2_HUMAN | Centrin-3 | CETN3 | 153 | Annotation score: | ||
E5RH67 | E5RH67_HUMAN | Centrin-3 | CETN3 | 111 | Annotation score: | ||
H0YBL5 | H0YBL5_HUMAN | Centrin-3 | CETN3 | 81 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC093510 Genomic DNA No translation available. |
RefSeqi | NP_001284694.1, NM_001297765.1 |
Genome annotation databases
Ensembli | ENST00000522083; ENSP00000428259; ENSG00000153140 |
GeneIDi | 1070 |
UCSCi | uc063fhr.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC093510 Genomic DNA No translation available. |
RefSeqi | NP_001284694.1, NM_001297765.1 |
3D structure databases
SMRi | E5RJF8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000428259 |
Proteomic databases
EPDi | E5RJF8 |
MaxQBi | E5RJF8 |
PeptideAtlasi | E5RJF8 |
PRIDEi | E5RJF8 |
ProteomicsDBi | 16586 |
Protocols and materials databases
Antibodypediai | 24818, 165 antibodies |
Genome annotation databases
Ensembli | ENST00000522083; ENSP00000428259; ENSG00000153140 |
GeneIDi | 1070 |
UCSCi | uc063fhr.1, human |
Organism-specific databases
CTDi | 1070 |
EuPathDBi | HostDB:ENSG00000153140.8 |
HGNCi | HGNC:1868, CETN3 |
OpenTargetsi | ENSG00000153140 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0028, Eukaryota |
GeneTreei | ENSGT00940000157995 |
OMAi | EFFAIMT |
OrthoDBi | 1340191at2759 |
PhylomeDBi | E5RJF8 |
Miscellaneous databases
BioGRID-ORCSi | 1070, 17 hits in 827 CRISPR screens |
ChiTaRSi | CETN3, human |
GenomeRNAii | 1070 |
Gene expression databases
Bgeei | ENSG00000153140, Expressed in testis and 247 other tissues |
ExpressionAtlasi | E5RJF8, baseline and differential |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E5RJF8_HUMAN | |
Accessioni | E5RJF8Primary (citable) accession number: E5RJF8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |