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Protein
Submitted name:

Ganglioside GM2 activator

Gene

GM2A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Ganglioside GM2 activatorImported
Gene namesi
Name:GM2AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000196743.8
HGNCiHGNC:4367 GM2A

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196743

PTM / Processingi

Proteomic databases

MaxQBiE5RJD0
PeptideAtlasiE5RJD0
PRIDEiE5RJD0

Expressioni

Gene expression databases

BgeeiENSG00000196743 Expressed in 239 organ(s), highest expression level in visceral pleura
ExpressionAtlasiE5RJD0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE5RJD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 141MLInterPro annotationAdd BLAST94

Phylogenomic databases

eggNOGiENOG410IX9N Eukaryota
ENOG4111JSM LUCA
GeneTreeiENSGT00390000003288

Family and domain databases

Gene3Di2.70.220.10, 1 hit
InterProiView protein in InterPro
IPR028996 GM2-AP
IPR036846 GM2-AP_sf
IPR003172 ML_dom
PANTHERiPTHR17357 PTHR17357, 1 hit
PfamiView protein in Pfam
PF02221 E1_DerP2_DerF2, 1 hit
SUPFAMiSSF63707 SSF63707, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E5RJD0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWVEAAGVS STALEDRIVA KHEEVPEVSV QYEEKFQNHH KLPSQLSSFS
60 70 80 90 100
WDNCDEGKDP AVIRSLTLEP DPIIVPGNVT LSVMGSTSVP LSSPLKVDLV
110 120 130 140
LEKEVAGLWI KIPCTDYIGS CTFEHFCDVL DMLIPTGEPC PEPLRT
Length:146
Mass (Da):16,065
Last modified:February 8, 2011 - v1
Checksum:i73E5AA1362DBECC6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P17900SAP3_HUMAN
Ganglioside GM2 activator
GM2A
193Annotation score:
H0YBY3H0YBY3_HUMAN
Ganglioside GM2 activator
GM2A
104Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei146Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008385 Genomic DNA No translation available.
AC011342 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000523466; ENSP00000429100; ENSG00000196743
UCSCiuc063iuv.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008385 Genomic DNA No translation available.
AC011342 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE5RJD0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE5RJD0
PeptideAtlasiE5RJD0
PRIDEiE5RJD0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000523466; ENSP00000429100; ENSG00000196743
UCSCiuc063iuv.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000196743.8
HGNCiHGNC:4367 GM2A
OpenTargetsiENSG00000196743
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX9N Eukaryota
ENOG4111JSM LUCA
GeneTreeiENSGT00390000003288

Miscellaneous databases

ChiTaRSiGM2A human

Gene expression databases

BgeeiENSG00000196743 Expressed in 239 organ(s), highest expression level in visceral pleura
ExpressionAtlasiE5RJD0 baseline and differential

Family and domain databases

Gene3Di2.70.220.10, 1 hit
InterProiView protein in InterPro
IPR028996 GM2-AP
IPR036846 GM2-AP_sf
IPR003172 ML_dom
PANTHERiPTHR17357 PTHR17357, 1 hit
PfamiView protein in Pfam
PF02221 E1_DerP2_DerF2, 1 hit
SUPFAMiSSF63707 SSF63707, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE5RJD0_HUMAN
AccessioniPrimary (citable) accession number: E5RJD0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 12, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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