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Protein
Submitted name:

Integrin beta-2

Gene

ITGB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiE5RIG7

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin beta-2Imported
Gene namesi
Name:ITGB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160255.16
HGNCiHGNC:6155 ITGB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160255

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500319687523 – 120Sequence analysisAdd BLAST98

Proteomic databases

MaxQBiE5RIG7
PeptideAtlasiE5RIG7
PRIDEiE5RIG7

Expressioni

Gene expression databases

BgeeiENSG00000160255 Expressed in 187 organ(s), highest expression level in blood
ExpressionAtlasiE5RIG7 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 74PSIInterPro annotationAdd BLAST51

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064

Family and domain databases

InterProiView protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015439 Integrin_bsu-2
IPR016201 PSI
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF15 PTHR10082:SF15, 1 hit
PfamiView protein in Pfam
PF17205 PSI_integrin, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00423 PSI, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.iShow all

E5RIG7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN
60 70 80 90 100
FTGPGDPDSI RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP
110 120
QKVTLYLRPG QAAAFNVTFR
Length:120
Mass (Da):13,015
Last modified:February 8, 2011 - v1
Checksum:i57878F51B9B69EF4
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P05107ITB2_HUMAN
Integrin beta-2
ITGB2 CD18, MFI7
769Annotation score:
D3DSM0D3DSM0_HUMAN
Integrin beta
ITGB2 hCG_401305
712Annotation score:
E7EVZ9E7EVZ9_HUMAN
Integrin beta
ITGB2
166Annotation score:
E5RK25E5RK25_HUMAN
Integrin beta
ITGB2
160Annotation score:
J3KNI6J3KNI6_HUMAN
Integrin beta
ITGB2
322Annotation score:
A8MVG7A8MVG7_HUMAN
Integrin beta-2
ITGB2
108Annotation score:
E5RFI0E5RFI0_HUMAN
Integrin beta-2
ITGB2
70Annotation score:
E5RIE4E5RIE4_HUMAN
Integrin beta-2
ITGB2
93Annotation score:
E5RHT0E5RHT0_HUMAN
Integrin beta-2
ITGB2
49Annotation score:
E5RK54E5RK54_HUMAN
Integrin beta-2
ITGB2
49Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei120Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773603 Genomic DNA No translation available.
AL844907 Genomic DNA No translation available.
AL844908 Genomic DNA No translation available.
KC877928 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000517563; ENSP00000428413; ENSG00000160255
UCSCiuc062aug.1 human

Similar proteinsi

Entry informationi

Entry nameiE5RIG7_HUMAN
AccessioniPrimary (citable) accession number: E5RIG7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 12, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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