Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 80 (07 Oct 2020)
Sequence version 1 (08 Feb 2011)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

CUB and sushi domain-containing protein 1

Gene

CSMD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CUB and sushi domain-containing protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSMD1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183117.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14026, CSMD1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3489 – 3510HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000183117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501457086927 – 3565Sequence analysisAdd BLAST3539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi554 ↔ 581PROSITE-ProRule annotation
Disulfide bondi900 ↔ 927PROSITE-ProRule annotation
Disulfide bondi1278 ↔ 1305PROSITE-ProRule annotation
Disulfide bondi2649 ↔ 2676PROSITE-ProRule annotation
Disulfide bondi2707 ↔ 2734PROSITE-ProRule annotation
Disulfide bondi2765 ↔ 2792PROSITE-ProRule annotation
Disulfide bondi2828 ↔ 2855PROSITE-ProRule annotation
Disulfide bondi2886 ↔ 2913PROSITE-ProRule annotation
Disulfide bondi2947 ↔ 2974PROSITE-ProRule annotation
Disulfide bondi3006 ↔ 3033PROSITE-ProRule annotation
Disulfide bondi3124 ↔ 3151PROSITE-ProRule annotation
Disulfide bondi3182 ↔ 3209PROSITE-ProRule annotation
Disulfide bondi3244 ↔ 3271PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
16276

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183117, Expressed in primary visual cortex and 156 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 140CUBInterPro annotationAdd BLAST109
Domaini143 – 204SushiInterPro annotationAdd BLAST62
Domaini208 – 312CUBInterPro annotationAdd BLAST105
Domaini347 – 409SushiInterPro annotationAdd BLAST63
Domaini412 – 523CUBInterPro annotationAdd BLAST112
Domaini526 – 583SushiInterPro annotationAdd BLAST58
Domaini585 – 693CUBInterPro annotationAdd BLAST109
Domaini696 – 757SushiInterPro annotationAdd BLAST62
Domaini759 – 867CUBInterPro annotationAdd BLAST109
Domaini872 – 929SushiInterPro annotationAdd BLAST58
Domaini931 – 1041CUBInterPro annotationAdd BLAST111
Domaini1044 – 1103SushiInterPro annotationAdd BLAST60
Domaini1105 – 1213CUBInterPro annotationAdd BLAST109
Domaini1216 – 1276SushiInterPro annotationAdd BLAST61
Domaini1278 – 1387CUBInterPro annotationAdd BLAST110
Domaini1390 – 1450SushiInterPro annotationAdd BLAST61
Domaini1452 – 1560CUBInterPro annotationAdd BLAST109
Domaini1563 – 1624SushiInterPro annotationAdd BLAST62
Domaini1626 – 1734CUBInterPro annotationAdd BLAST109
Domaini1740 – 1801SushiInterPro annotationAdd BLAST62
Domaini1803 – 1911CUBInterPro annotationAdd BLAST109
Domaini1914 – 1973SushiInterPro annotationAdd BLAST60
Domaini1975 – 2083CUBInterPro annotationAdd BLAST109
Domaini2086 – 2145SushiInterPro annotationAdd BLAST60
Domaini2147 – 2258CUBInterPro annotationAdd BLAST112
Domaini2257 – 2318SushiInterPro annotationAdd BLAST62
Domaini2320 – 2431CUBInterPro annotationAdd BLAST112
Domaini2431 – 2493SushiInterPro annotationAdd BLAST63
Domaini2494 – 2555SushiInterPro annotationAdd BLAST62
Domaini2556 – 2620SushiInterPro annotationAdd BLAST65
Domaini2621 – 2678SushiInterPro annotationAdd BLAST58
Domaini2679 – 2736SushiInterPro annotationAdd BLAST58
Domaini2737 – 2794SushiInterPro annotationAdd BLAST58
Domaini2795 – 2857SushiInterPro annotationAdd BLAST63
Domaini2858 – 2915SushiInterPro annotationAdd BLAST58
Domaini2919 – 2976SushiInterPro annotationAdd BLAST58
Domaini2977 – 3035SushiInterPro annotationAdd BLAST59
Domaini3036 – 3095SushiInterPro annotationAdd BLAST60
Domaini3096 – 3153SushiInterPro annotationAdd BLAST58
Domaini3154 – 3211SushiInterPro annotationAdd BLAST58
Domaini3215 – 3273SushiInterPro annotationAdd BLAST59
Domaini3274 – 3333SushiInterPro annotationAdd BLAST60

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155701

Identification of Orthologs from Complete Genome Data

More...
OMAi
SPGFCGD

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 28 hits
cd00041, CUB, 14 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 14 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 14 hits
PF00084, Sushi, 28 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 28 hits
SM00042, CUB, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 14 hits
SSF57535, SSF57535, 28 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 14 hits
PS50923, SUSHI, 28 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E5RIG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAWRRFQSL LLLLGLLVLC ARLLTAAKGQ NCGGLVQGPN GTIESPGFPH
60 70 80 90 100
GYPNYANCTW IIITGERNRI QLSFHTFALE EDFDILSVYD GQPQQGNLKV
110 120 130 140 150
RLSGFQLPSS IVSTGSILTL WFTTDFAVSA QGFKALYEVL PSHTCGNPGE
160 170 180 190 200
ILKGVLHGTR FNIGDKIRYS CLPGYILEGH AILTCIVSPG NGASWDFPAP
210 220 230 240 250
FCRAEGACGG TLRGTSSSIS SPHFPSEYEN NADCTWTILA EPGDTIALVF
260 270 280 290 300
TDFQLEEGYD FLEISGTEAP SIWLTGMNLP SPVISSKNWL RLHFTSDSNH
310 320 330 340 350
RRKGFNAQFQ VKKAIELKSR GVKMLPSKDG SHKNSVLSQG GVALVSDMCP
360 370 380 390 400
DPGIPENGRR AGSDFSRVGA NVQFSCEDNY VLQGSKSITC QRVTETLAAW
410 420 430 440 450
SDHRPICRAR TCGSNLRGPS GVITSPNYPV QYEDNAHCVW VITTTDPDKV
460 470 480 490 500
IKLAFEEFEL ERGYDTLTVG DAGKVGDTRS VLYVLTGSSV PDLIVSMSNQ
510 520 530 540 550
MWLHLQSDDS IGSPGFKAVY QEIEKGGCGD PGIPAYGKRT GSSFLHGDTL
560 570 580 590 600
TFECPAAFEL VGERVITCQQ NNQWSGNKPS CVFSCFFNFT ASSGIILSPN
610 620 630 640 650
YPEEYGNNMN CVWLIISEPG SRIHLIFNDF DVEPQFDFLA VKDDGISDIT
660 670 680 690 700
VLGTFSGNEV PSQLASSGHI VRLEFQSDHS TTGRGFNITY TTFGQNECHD
710 720 730 740 750
PGIPINGRRF GDRFLLGSSV SFHCDDGFVK TQGSESITCI LQDGNVVWSS
760 770 780 790 800
TVPRCEAPCG GHLTASSGVI LPPGWPGYYK DSLHCEWIIE AKPGHSIKIT
810 820 830 840 850
FDRFQTEVNY DTLEVRDGPA SSSPLIGEYH GTQAPQFLIS TGNFMYLLFT
860 870 880 890 900
TDNSRSSIGF LIHYESVTLE SDSCLDPGIP VNGHRHGGDF GIRSTVTFSC
910 920 930 940 950
DPGYTLSDDE PLVCERNHQW NHALPSCDAL CGGYIQGKSG TVLSPGFPDF
960 970 980 990 1000
YPNSLNCTWT IEVSHGKGVQ MIFHTFHLES SHDYLLITED GSFSEPVARL
1010 1020 1030 1040 1050
TGSVLPHTIK AGLFGNFTAQ LRFISDFSIS YEGFNITFSE YDLEPCDDPG
1060 1070 1080 1090 1100
VPAFSRRIGF HFGVGDSLTF SCFLGYRLEG ATKLTCLGGG RRVWSAPLPR
1110 1120 1130 1140 1150
CVAECGASVK GNEGTLLSPN FPSNYDNNHE CIYKIETEAG KGIHLRTRSF
1160 1170 1180 1190 1200
QLFEGDTLKV YDGKDSSSRP LGTFTKNELL GLILNSTSNH LWLEFNTNGS
1210 1220 1230 1240 1250
DTDQGFQLTY TSFDLVKCED PGIPNYGYRI RDEGHFTDTV VLYSCNPGYA
1260 1270 1280 1290 1300
MHGSNTLTCL SGDRRVWDKP LPSCIAECGG QIHAATSGRI LSPGYPAPYD
1310 1320 1330 1340 1350
NNLHCTWIIE ADPGKTISLH FIVFDTEMAH DILKVWDGPV DSDILLKEWS
1360 1370 1380 1390 1400
GSALPEDIHS TFNSLTLQFD SDFFISKSGF SIQFSTSIAA TCNDPGMPQN
1410 1420 1430 1440 1450
GTRYGDSREA GDTVTFQCDP GYQLQGQAKI TCVQLNNRFF WQPDPPTCIA
1460 1470 1480 1490 1500
ACGGNLTGPA GVILSPNYPQ PYPPGKECDW RVKVNPDFVI ALIFKSFNME
1510 1520 1530 1540 1550
PSYDFLHIYE GEDSNSPLIG SYQGSQAPER IESSGNSLFL AFRSDASVGL
1560 1570 1580 1590 1600
SGFAIEFKEK PREACFDPGN IMNGTRVGTD FKLGSTITYQ CDSGYKILDP
1610 1620 1630 1640 1650
SSITCVIGAD GKPSWDQVLP SCNAPCGGQY TGSEGVVLSP NYPHNYTAGQ
1660 1670 1680 1690 1700
ICLYSITVPK EFVVFGQFAY FQTALNDLAE LFDGTHAQAR LLSSLSGSHS
1710 1720 1730 1740 1750
GETLPLATSN QILLRFSAKS GASARGFHFV YQAVPRTSDT QCSSVPEPRY
1760 1770 1780 1790 1800
GRRIGSEFSA GSIVRFECNP GYLLQGSTAL HCQSVPNALA QWNDTIPSCV
1810 1820 1830 1840 1850
VPCSGNFTQR RGTILSPGYP EPYGNNLNCI WKIIVTEGSG IQIQVISFAT
1860 1870 1880 1890 1900
EQNWDSLEIH DGGDVTAPRL GSFSGTTVPA LLNSTSNQLY LHFQSDISVA
1910 1920 1930 1940 1950
AAGFHLEYKT VGLAACQEPA LPSNSIKIGD RYMVNDVLSF QCEPGYTLQG
1960 1970 1980 1990 2000
RSHISCMPGT VRRWNYPSPL CIATCGGTLS TLGGVILSPG FPGSYPNNLD
2010 2020 2030 2040 2050
CTWRISLPIG YGAHIQFLNF STEANHDFLE IQNGPYHTSP MIGQFSGTDL
2060 2070 2080 2090 2100
PAALLSTTHE TLIHFYSDHS QNRQGFKLAY QAYELQNCPD PPPFQNGYMI
2110 2120 2130 2140 2150
NSDYSVGQSV SFECYPGYIL IGHPVLTCQH GINRNWNYPF PRCDAPCGYN
2160 2170 2180 2190 2200
VTSQNGTIYS PGFPDEYPIL KDCIWLITVP PGHGVYINFT LLQTEAVNDY
2210 2220 2230 2240 2250
IAVWDGPDQN SPQLGVFSGN TALETAYSST NQVLLKFHSD FSNGGFFVLN
2260 2270 2280 2290 2300
FHAFQLKKCQ PPPAVPQAEM LTEDDDFEIG DFVKYQCHPG YTLVGTDILT
2310 2320 2330 2340 2350
CKLSSQLQFE GSLPTCEAQC PANEVRTGSS GVILSPGYPG NYFNSQTCSW
2360 2370 2380 2390 2400
SIKVEPNYNI TIFVDTFQSE KQFDALEVFD GSSGQSPLLV VLSGNHTEQS
2410 2420 2430 2440 2450
NFTSRSNQLY LRWSTDHATS KKGFKIRYAA PYCSLTHPLK NGGILNRTAG
2460 2470 2480 2490 2500
AVGSKVHYFC KPGYRMVGHS NATCRRNPLG MYQWDSLTPL CQAVSCGIPE
2510 2520 2530 2540 2550
SPGNGSFTGN EFTLDSKVVY ECHEGFKLES SQQATAVCQE DGLWSNKGKP
2560 2570 2580 2590 2600
PTCKPVACPS IEAQLSEHVI WRLVSGSLNE YGAQVLLSCS PGYYLEGWRL
2610 2620 2630 2640 2650
LRCQANGTWN IGDERPSCRV ISCGSLSFPP NGNKIGTLTV YGATAIFTCN
2660 2670 2680 2690 2700
TGYTLVGSHV RECLANGLWS GSETRCLAGH CGSPDPIVNG HISGDGFSYR
2710 2720 2730 2740 2750
DTVVYQCNPG FRLVGTSVRI CLQDHKWSGQ TPVCVPITCG HPGNPAHGFT
2760 2770 2780 2790 2800
NGSEFNLNDV VNFTCNTGYL LQGVSRAQCR SNGQWSSPLP TCRVVNCSDP
2810 2820 2830 2840 2850
GFVENAIRHG QQNFPESFEY GMSILYHCKK GFYLLGSSAL TCMANGLWDR
2860 2870 2880 2890 2900
SLPKCLAISC GHPGVPANAV LTGELFTYGA VVHYSCRGSE SLIGNDTRVC
2910 2920 2930 2940 2950
QEDSHWSGAL PHCTGNNPGF CGDPGTPAHG SRLGDDFKTK SLLRFSCEMG
2960 2970 2980 2990 3000
HQLRGSPERT CLLNGSWSGL QPVCEAVSCG NPGTPTNGMI VSSDGILFSS
3010 3020 3030 3040 3050
SVIYACWEGY KTSGLMTRHC TANGTWTGTA PDCTIISCGD PGTLANGIQF
3060 3070 3080 3090 3100
GTDFTFNKTV SYQCNPGYVM EAVTSATIRC TKDGRWNPSK PVCKAVLCPQ
3110 3120 3130 3140 3150
PPPVQNGTVE GSDFRWGSSI SYSCMDGYQL SHSAILSCEG RGVWKGEIPQ
3160 3170 3180 3190 3200
CLPVFCGDPG IPAEGRLSGK SFTYKSEVFF QCKSPFILVG SSRRVCQADG
3210 3220 3230 3240 3250
TWSGIQPTCI DPAHNTCPDP GTPHFGIQNS SRGYEVGSTV FFRCRKGYHI
3260 3270 3280 3290 3300
QGSTTRTCLA NLTWSGIQTE CIPHACRQPE TPAHADVRAI DLPTFGYTLV
3310 3320 3330 3340 3350
YTCHPGFFLA GGSEHRTCKA DMKWTGKSPV CKSKGVREVN ETVTKTPVPS
3360 3370 3380 3390 3400
DVFFVNSLWK GYYEYLGKRQ PATLTVDWFN ATSSKVNATF SEASPVELKL
3410 3420 3430 3440 3450
TGIYKKEEAH LLLKAFQIKG QADIFVSKFE NDNWGLDGYV SSGLERGGFT
3460 3470 3480 3490 3500
FQGDIHGKDF GKFKLERQDP LNPDQDSSSH YHGTSSGSVA AAILVPFFAL
3510 3520 3530 3540 3550
ILSGFAFYLY KHRTRPKVQY NGYAGHENSN GQASFENPMY DTNLKPTEAK
3560
AVRFDTTLNT VCTVV
Length:3,565
Mass (Da):388,823
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31218D4461751B87
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96PZ7CSMD1_HUMAN
CUB and sushi domain-containing pro...
CSMD1 KIAA1890, UNQ5952/PRO19863
3,564Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9C3F8W9C3_HUMAN
CUB and sushi domain-containing pro...
CSMD1
3,388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZ18F5GZ18_HUMAN
CUB and sushi domain-containing pro...
CSMD1
3,426Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXU2H7BXU2_HUMAN
CUB and sushi domain-containing pro...
CSMD1
2,967Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC021523 Genomic DNA No translation available.
AC023296 Genomic DNA No translation available.
AC026991 Genomic DNA No translation available.
AC087692 Genomic DNA No translation available.
AC135324 Genomic DNA No translation available.
KF458665 Genomic DNA No translation available.
KF458666 Genomic DNA No translation available.
KF458667 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000520002; ENSP00000430733; ENSG00000183117
ENST00000602557; ENSP00000473359; ENSG00000183117

UCSC genome browser

More...
UCSCi
uc064jzo.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021523 Genomic DNA No translation available.
AC023296 Genomic DNA No translation available.
AC026991 Genomic DNA No translation available.
AC087692 Genomic DNA No translation available.
AC135324 Genomic DNA No translation available.
KF458665 Genomic DNA No translation available.
KF458666 Genomic DNA No translation available.
KF458667 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

ProteomicsDBi16276

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
52810, 77 antibodies

Genome annotation databases

EnsembliENST00000520002; ENSP00000430733; ENSG00000183117
ENST00000602557; ENSP00000473359; ENSG00000183117
UCSCiuc064jzo.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000183117.18
HGNCiHGNC:14026, CSMD1
OpenTargetsiENSG00000183117

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155701
OMAiSPGFCGD

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CSMD1, human

Gene expression databases

BgeeiENSG00000183117, Expressed in primary visual cortex and 156 other tissues

Family and domain databases

CDDicd00033, CCP, 28 hits
cd00041, CUB, 14 hits
Gene3Di2.60.120.290, 14 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431, CUB, 14 hits
PF00084, Sushi, 28 hits
SMARTiView protein in SMART
SM00032, CCP, 28 hits
SM00042, CUB, 14 hits
SUPFAMiSSF49854, SSF49854, 14 hits
SSF57535, SSF57535, 28 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 14 hits
PS50923, SUSHI, 28 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5RIG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5RIG2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 7, 2020
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again