Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - E5RIG2 (E5RIG2_HUMAN)

Entry version 81 (02 Dec 2020)
Sequence version 1 (08 Feb 2011)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

CUB and sushi domain-containing protein 1

Gene

CSMD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CUB and sushi domain-containing protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSMD1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000183117.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:14026, CSMD1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3489 – 3510HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000183117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501457086927 – 3565Sequence analysisAdd BLAST3539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi554 ↔ 581PROSITE-ProRule annotation
Disulfide bondi900 ↔ 927PROSITE-ProRule annotation
Disulfide bondi1278 ↔ 1305PROSITE-ProRule annotation
Disulfide bondi2649 ↔ 2676PROSITE-ProRule annotation
Disulfide bondi2707 ↔ 2734PROSITE-ProRule annotation
Disulfide bondi2765 ↔ 2792PROSITE-ProRule annotation
Disulfide bondi2828 ↔ 2855PROSITE-ProRule annotation
Disulfide bondi2886 ↔ 2913PROSITE-ProRule annotation
Disulfide bondi2947 ↔ 2974PROSITE-ProRule annotation
Disulfide bondi3006 ↔ 3033PROSITE-ProRule annotation
Disulfide bondi3124 ↔ 3151PROSITE-ProRule annotation
Disulfide bondi3182 ↔ 3209PROSITE-ProRule annotation
Disulfide bondi3244 ↔ 3271PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		16276

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183117, Expressed in primary visual cortex and 156 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 140CUBInterPro annotationAdd BLAST109
Domaini143 – 204SushiInterPro annotationAdd BLAST62
Domaini208 – 312CUBInterPro annotationAdd BLAST105
Domaini347 – 409SushiInterPro annotationAdd BLAST63
Domaini412 – 523CUBInterPro annotationAdd BLAST112
Domaini526 – 583SushiInterPro annotationAdd BLAST58
Domaini585 – 693CUBInterPro annotationAdd BLAST109
Domaini696 – 757SushiInterPro annotationAdd BLAST62
Domaini759 – 867CUBInterPro annotationAdd BLAST109
Domaini872 – 929SushiInterPro annotationAdd BLAST58
Domaini931 – 1041CUBInterPro annotationAdd BLAST111
Domaini1044 – 1103SushiInterPro annotationAdd BLAST60
Domaini1105 – 1213CUBInterPro annotationAdd BLAST109
Domaini1216 – 1276SushiInterPro annotationAdd BLAST61
Domaini1278 – 1387CUBInterPro annotationAdd BLAST110
Domaini1390 – 1450SushiInterPro annotationAdd BLAST61
Domaini1452 – 1560CUBInterPro annotationAdd BLAST109
Domaini1563 – 1624SushiInterPro annotationAdd BLAST62
Domaini1626 – 1734CUBInterPro annotationAdd BLAST109
Domaini1740 – 1801SushiInterPro annotationAdd BLAST62
Domaini1803 – 1911CUBInterPro annotationAdd BLAST109
Domaini1914 – 1973SushiInterPro annotationAdd BLAST60
Domaini1975 – 2083CUBInterPro annotationAdd BLAST109
Domaini2086 – 2145SushiInterPro annotationAdd BLAST60
Domaini2147 – 2258CUBInterPro annotationAdd BLAST112
Domaini2257 – 2318SushiInterPro annotationAdd BLAST62
Domaini2320 – 2431CUBInterPro annotationAdd BLAST112
Domaini2431 – 2493SushiInterPro annotationAdd BLAST63
Domaini2494 – 2555SushiInterPro annotationAdd BLAST62
Domaini2556 – 2620SushiInterPro annotationAdd BLAST65
Domaini2621 – 2678SushiInterPro annotationAdd BLAST58
Domaini2679 – 2736SushiInterPro annotationAdd BLAST58
Domaini2737 – 2794SushiInterPro annotationAdd BLAST58
Domaini2795 – 2857SushiInterPro annotationAdd BLAST63
Domaini2858 – 2915SushiInterPro annotationAdd BLAST58
Domaini2919 – 2976SushiInterPro annotationAdd BLAST58
Domaini2977 – 3035SushiInterPro annotationAdd BLAST59
Domaini3036 – 3095SushiInterPro annotationAdd BLAST60
Domaini3096 – 3153SushiInterPro annotationAdd BLAST58
Domaini3154 – 3211SushiInterPro annotationAdd BLAST58
Domaini3215 – 3273SushiInterPro annotationAdd BLAST59
Domaini3274 – 3333SushiInterPro annotationAdd BLAST60

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155701

Identification of Orthologs from Complete Genome Data

More...OMAi		SPGFCGD

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 28 hits
cd00041, CUB, 14 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.290, 14 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 14 hits
PF00084, Sushi, 28 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 28 hits
SM00042, CUB, 14 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49854, SSF49854, 14 hits
SSF57535, SSF57535, 28 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180, CUB, 14 hits
PS50923, SUSHI, 28 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E5RIG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAWRRFQSL LLLLGLLVLC ARLLTAAKGQ NCGGLVQGPN GTIESPGFPH 
        60         70         80         90        100
GYPNYANCTW IIITGERNRI QLSFHTFALE EDFDILSVYD GQPQQGNLKV 
       110        120        130        140        150
RLSGFQLPSS IVSTGSILTL WFTTDFAVSA QGFKALYEVL PSHTCGNPGE 
       160        170        180        190        200
ILKGVLHGTR FNIGDKIRYS CLPGYILEGH AILTCIVSPG NGASWDFPAP 
       210        220        230        240        250
FCRAEGACGG TLRGTSSSIS SPHFPSEYEN NADCTWTILA EPGDTIALVF 
       260        270        280        290        300
TDFQLEEGYD FLEISGTEAP SIWLTGMNLP SPVISSKNWL RLHFTSDSNH 
       310        320        330        340        350
RRKGFNAQFQ VKKAIELKSR GVKMLPSKDG SHKNSVLSQG GVALVSDMCP 
       360        370        380        390        400
DPGIPENGRR AGSDFSRVGA NVQFSCEDNY VLQGSKSITC QRVTETLAAW 
       410        420        430        440        450
SDHRPICRAR TCGSNLRGPS GVITSPNYPV QYEDNAHCVW VITTTDPDKV 
       460        470        480        490        500
IKLAFEEFEL ERGYDTLTVG DAGKVGDTRS VLYVLTGSSV PDLIVSMSNQ 
       510        520        530        540        550
MWLHLQSDDS IGSPGFKAVY QEIEKGGCGD PGIPAYGKRT GSSFLHGDTL 
       560        570        580        590        600
TFECPAAFEL VGERVITCQQ NNQWSGNKPS CVFSCFFNFT ASSGIILSPN 
       610        620        630        640        650
YPEEYGNNMN CVWLIISEPG SRIHLIFNDF DVEPQFDFLA VKDDGISDIT 
       660        670        680        690        700
VLGTFSGNEV PSQLASSGHI VRLEFQSDHS TTGRGFNITY TTFGQNECHD 
       710        720        730        740        750
PGIPINGRRF GDRFLLGSSV SFHCDDGFVK TQGSESITCI LQDGNVVWSS 
       760        770        780        790        800
TVPRCEAPCG GHLTASSGVI LPPGWPGYYK DSLHCEWIIE AKPGHSIKIT 
       810        820        830        840        850
FDRFQTEVNY DTLEVRDGPA SSSPLIGEYH GTQAPQFLIS TGNFMYLLFT 
       860        870        880        890        900
TDNSRSSIGF LIHYESVTLE SDSCLDPGIP VNGHRHGGDF GIRSTVTFSC 
       910        920        930        940        950
DPGYTLSDDE PLVCERNHQW NHALPSCDAL CGGYIQGKSG TVLSPGFPDF 
       960        970        980        990       1000
YPNSLNCTWT IEVSHGKGVQ MIFHTFHLES SHDYLLITED GSFSEPVARL 
      1010       1020       1030       1040       1050
TGSVLPHTIK AGLFGNFTAQ LRFISDFSIS YEGFNITFSE YDLEPCDDPG 
      1060       1070       1080       1090       1100
VPAFSRRIGF HFGVGDSLTF SCFLGYRLEG ATKLTCLGGG RRVWSAPLPR 
      1110       1120       1130       1140       1150
CVAECGASVK GNEGTLLSPN FPSNYDNNHE CIYKIETEAG KGIHLRTRSF 
      1160       1170       1180       1190       1200
QLFEGDTLKV YDGKDSSSRP LGTFTKNELL GLILNSTSNH LWLEFNTNGS 
      1210       1220       1230       1240       1250
DTDQGFQLTY TSFDLVKCED PGIPNYGYRI RDEGHFTDTV VLYSCNPGYA 
      1260       1270       1280       1290       1300
MHGSNTLTCL SGDRRVWDKP LPSCIAECGG QIHAATSGRI LSPGYPAPYD 
      1310       1320       1330       1340       1350
NNLHCTWIIE ADPGKTISLH FIVFDTEMAH DILKVWDGPV DSDILLKEWS 
      1360       1370       1380       1390       1400
GSALPEDIHS TFNSLTLQFD SDFFISKSGF SIQFSTSIAA TCNDPGMPQN 
      1410       1420       1430       1440       1450
GTRYGDSREA GDTVTFQCDP GYQLQGQAKI TCVQLNNRFF WQPDPPTCIA 
      1460       1470       1480       1490       1500
ACGGNLTGPA GVILSPNYPQ PYPPGKECDW RVKVNPDFVI ALIFKSFNME 
      1510       1520       1530       1540       1550
PSYDFLHIYE GEDSNSPLIG SYQGSQAPER IESSGNSLFL AFRSDASVGL 
      1560       1570       1580       1590       1600
SGFAIEFKEK PREACFDPGN IMNGTRVGTD FKLGSTITYQ CDSGYKILDP 
      1610       1620       1630       1640       1650
SSITCVIGAD GKPSWDQVLP SCNAPCGGQY TGSEGVVLSP NYPHNYTAGQ 
      1660       1670       1680       1690       1700
ICLYSITVPK EFVVFGQFAY FQTALNDLAE LFDGTHAQAR LLSSLSGSHS 
      1710       1720       1730       1740       1750
GETLPLATSN QILLRFSAKS GASARGFHFV YQAVPRTSDT QCSSVPEPRY 
      1760       1770       1780       1790       1800
GRRIGSEFSA GSIVRFECNP GYLLQGSTAL HCQSVPNALA QWNDTIPSCV 
      1810       1820       1830       1840       1850
VPCSGNFTQR RGTILSPGYP EPYGNNLNCI WKIIVTEGSG IQIQVISFAT 
      1860       1870       1880       1890       1900
EQNWDSLEIH DGGDVTAPRL GSFSGTTVPA LLNSTSNQLY LHFQSDISVA 
      1910       1920       1930       1940       1950
AAGFHLEYKT VGLAACQEPA LPSNSIKIGD RYMVNDVLSF QCEPGYTLQG 
      1960       1970       1980       1990       2000
RSHISCMPGT VRRWNYPSPL CIATCGGTLS TLGGVILSPG FPGSYPNNLD 
      2010       2020       2030       2040       2050
CTWRISLPIG YGAHIQFLNF STEANHDFLE IQNGPYHTSP MIGQFSGTDL 
      2060       2070       2080       2090       2100
PAALLSTTHE TLIHFYSDHS QNRQGFKLAY QAYELQNCPD PPPFQNGYMI 
      2110       2120       2130       2140       2150
NSDYSVGQSV SFECYPGYIL IGHPVLTCQH GINRNWNYPF PRCDAPCGYN 
      2160       2170       2180       2190       2200
VTSQNGTIYS PGFPDEYPIL KDCIWLITVP PGHGVYINFT LLQTEAVNDY 
      2210       2220       2230       2240       2250
IAVWDGPDQN SPQLGVFSGN TALETAYSST NQVLLKFHSD FSNGGFFVLN 
      2260       2270       2280       2290       2300
FHAFQLKKCQ PPPAVPQAEM LTEDDDFEIG DFVKYQCHPG YTLVGTDILT 
      2310       2320       2330       2340       2350
CKLSSQLQFE GSLPTCEAQC PANEVRTGSS GVILSPGYPG NYFNSQTCSW 
      2360       2370       2380       2390       2400
SIKVEPNYNI TIFVDTFQSE KQFDALEVFD GSSGQSPLLV VLSGNHTEQS 
      2410       2420       2430       2440       2450
NFTSRSNQLY LRWSTDHATS KKGFKIRYAA PYCSLTHPLK NGGILNRTAG 
      2460       2470       2480       2490       2500
AVGSKVHYFC KPGYRMVGHS NATCRRNPLG MYQWDSLTPL CQAVSCGIPE 
      2510       2520       2530       2540       2550
SPGNGSFTGN EFTLDSKVVY ECHEGFKLES SQQATAVCQE DGLWSNKGKP 
      2560       2570       2580       2590       2600
PTCKPVACPS IEAQLSEHVI WRLVSGSLNE YGAQVLLSCS PGYYLEGWRL 
      2610       2620       2630       2640       2650
LRCQANGTWN IGDERPSCRV ISCGSLSFPP NGNKIGTLTV YGATAIFTCN 
      2660       2670       2680       2690       2700
TGYTLVGSHV RECLANGLWS GSETRCLAGH CGSPDPIVNG HISGDGFSYR 
      2710       2720       2730       2740       2750
DTVVYQCNPG FRLVGTSVRI CLQDHKWSGQ TPVCVPITCG HPGNPAHGFT 
      2760       2770       2780       2790       2800
NGSEFNLNDV VNFTCNTGYL LQGVSRAQCR SNGQWSSPLP TCRVVNCSDP 
      2810       2820       2830       2840       2850
GFVENAIRHG QQNFPESFEY GMSILYHCKK GFYLLGSSAL TCMANGLWDR 
      2860       2870       2880       2890       2900
SLPKCLAISC GHPGVPANAV LTGELFTYGA VVHYSCRGSE SLIGNDTRVC 
      2910       2920       2930       2940       2950
QEDSHWSGAL PHCTGNNPGF CGDPGTPAHG SRLGDDFKTK SLLRFSCEMG 
      2960       2970       2980       2990       3000
HQLRGSPERT CLLNGSWSGL QPVCEAVSCG NPGTPTNGMI VSSDGILFSS 
      3010       3020       3030       3040       3050
SVIYACWEGY KTSGLMTRHC TANGTWTGTA PDCTIISCGD PGTLANGIQF 
      3060       3070       3080       3090       3100
GTDFTFNKTV SYQCNPGYVM EAVTSATIRC TKDGRWNPSK PVCKAVLCPQ 
      3110       3120       3130       3140       3150
PPPVQNGTVE GSDFRWGSSI SYSCMDGYQL SHSAILSCEG RGVWKGEIPQ 
      3160       3170       3180       3190       3200
CLPVFCGDPG IPAEGRLSGK SFTYKSEVFF QCKSPFILVG SSRRVCQADG 
      3210       3220       3230       3240       3250
TWSGIQPTCI DPAHNTCPDP GTPHFGIQNS SRGYEVGSTV FFRCRKGYHI 
      3260       3270       3280       3290       3300
QGSTTRTCLA NLTWSGIQTE CIPHACRQPE TPAHADVRAI DLPTFGYTLV 
      3310       3320       3330       3340       3350
YTCHPGFFLA GGSEHRTCKA DMKWTGKSPV CKSKGVREVN ETVTKTPVPS 
      3360       3370       3380       3390       3400
DVFFVNSLWK GYYEYLGKRQ PATLTVDWFN ATSSKVNATF SEASPVELKL 
      3410       3420       3430       3440       3450
TGIYKKEEAH LLLKAFQIKG QADIFVSKFE NDNWGLDGYV SSGLERGGFT 
      3460       3470       3480       3490       3500
FQGDIHGKDF GKFKLERQDP LNPDQDSSSH YHGTSSGSVA AAILVPFFAL 
      3510       3520       3530       3540       3550
ILSGFAFYLY KHRTRPKVQY NGYAGHENSN GQASFENPMY DTNLKPTEAK 
      3560 
AVRFDTTLNT VCTVV
Length:3,565
Mass (Da):388,823
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31218D4461751B87
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96PZ7CSMD1_HUMAN
CUB and sushi domain-containing pro...
CSMD1 KIAA1890, UNQ5952/PRO19863
3,564Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9C3F8W9C3_HUMAN
CUB and sushi domain-containing pro...
CSMD1
3,388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZ18F5GZ18_HUMAN
CUB and sushi domain-containing pro...
CSMD1
3,426Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXU2H7BXU2_HUMAN
CUB and sushi domain-containing pro...
CSMD1
2,967Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC021523 Genomic DNA No translation available.
AC023296 Genomic DNA No translation available.
AC026991 Genomic DNA No translation available.
AC087692 Genomic DNA No translation available.
AC135324 Genomic DNA No translation available.
KF458665 Genomic DNA No translation available.
KF458666 Genomic DNA No translation available.
KF458667 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000520002; ENSP00000430733; ENSG00000183117
ENST00000602557; ENSP00000473359; ENSG00000183117

UCSC genome browser

More...UCSCi		uc064jzo.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021523 Genomic DNA No translation available.
AC023296 Genomic DNA No translation available.
AC026991 Genomic DNA No translation available.
AC087692 Genomic DNA No translation available.
AC135324 Genomic DNA No translation available.
KF458665 Genomic DNA No translation available.
KF458666 Genomic DNA No translation available.
KF458667 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

ProteomicsDBi16276

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		52810, 78 antibodies

Genome annotation databases

EnsembliENST00000520002; ENSP00000430733; ENSG00000183117
ENST00000602557; ENSP00000473359; ENSG00000183117
UCSCiuc064jzo.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000183117.18
HGNCiHGNC:14026, CSMD1
OpenTargetsiENSG00000183117

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000155701
OMAiSPGFCGD

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CSMD1, human

Gene expression databases

BgeeiENSG00000183117, Expressed in primary visual cortex and 156 other tissues

Family and domain databases

CDDicd00033, CCP, 28 hits
cd00041, CUB, 14 hits
Gene3Di2.60.120.290, 14 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431, CUB, 14 hits
PF00084, Sushi, 28 hits
SMARTiView protein in SMART
SM00032, CCP, 28 hits
SM00042, CUB, 14 hits
SUPFAMiSSF49854, SSF49854, 14 hits
SSF57535, SSF57535, 28 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 14 hits
PS50923, SUSHI, 28 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5RIG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5RIG2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: December 2, 2020
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again