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Protein
Submitted name:

Carbonic anhydrase 1

Gene

CA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Carbonic anhydrase 1Imported
Gene namesi
Name:CA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000133742.13
HGNCiHGNC:1368 CA1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133742

PTM / Processingi

Proteomic databases

PeptideAtlasiE5RIF9
PRIDEiE5RIF9

Expressioni

Gene expression databases

BgeeiENSG00000133742 Expressed in 126 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiE5RIF9 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 148Alpha-carbonic anhydraseInterPro annotationAdd BLAST145

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
IPR018442 Carbonic_anhydrase_CA1
PANTHERiPTHR18952 PTHR18952, 1 hit
PTHR18952:SF82 PTHR18952:SF82, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All

E5RIF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPDWGYDD KNGPEQWSKL YPIANGNNQS PVDIKTSETK HDTSLKPISV
60 70 80 90 100
SYNPATAKEI INVGHSFHVN FEDNDNRSVL KGGPFSDSYR LFQFHFHWGS
110 120 130 140
TNEHGSEHTV DGVKYSAELH VAHWNSAKYS SLAEAASKAD GLAVIGVL
Length:148
Mass (Da):16,318
Last modified:February 8, 2011 - v1
Checksum:i856DB604999122C7
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P00915CAH1_HUMAN
Carbonic anhydrase 1
CA1
261Annotation score:
E5RFL2E5RFL2_HUMAN
Carbonic anhydrase 1
CA1
118Annotation score:
E5RHP7E5RHP7_HUMAN
Carbonic anhydrase 1
CA1
251Annotation score:
E5RII2E5RII2_HUMAN
Carbonic anhydrase 1
CA1
81Annotation score:
E5RH81E5RH81_HUMAN
Carbonic anhydrase 1
CA1
175Annotation score:
E5RGU8E5RGU8_HUMAN
Carbonic anhydrase 1
CA1
99Annotation score:
E5RG43E5RG43_HUMAN
Carbonic anhydrase 1
CA1
149Annotation score:
E5RFE7E5RFE7_HUMAN
Carbonic anhydrase 1
CA1
194Annotation score:
E5RJI8E5RJI8_HUMAN
Carbonic anhydrase 1
CA1
137Annotation score:
E5RJF6E5RJF6_HUMAN
Carbonic anhydrase 1
CA1
87Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei148Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025800 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000522814; ENSP00000430737; ENSG00000133742
UCSCiuc064odo.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025800 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiE5RIF9
PRIDEiE5RIF9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000522814; ENSP00000430737; ENSG00000133742
UCSCiuc064odo.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000133742.13
HGNCiHGNC:1368 CA1
OpenTargetsiENSG00000133742
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915

Gene expression databases

BgeeiENSG00000133742 Expressed in 126 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiE5RIF9 baseline and differential

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
IPR018442 Carbonic_anhydrase_CA1
PANTHERiPTHR18952 PTHR18952, 1 hit
PTHR18952:SF82 PTHR18952:SF82, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE5RIF9_HUMAN
AccessioniPrimary (citable) accession number: E5RIF9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 12, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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