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Protein
Submitted name:

Erlin-2

Gene

ERLIN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Erlin-2Imported
Gene namesi
Name:ERLIN2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147475.14
HGNCiHGNC:1356 ERLIN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147475

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500319687126 – 338Sequence analysisAdd BLAST313

Proteomic databases

EPDiE5RHW4
MaxQBiE5RHW4
PeptideAtlasiE5RHW4
PRIDEiE5RHW4

Expressioni

Gene expression databases

BgeeiENSG00000147475 Expressed in 219 organ(s), highest expression level in choroid plexus epithelium
ExpressionAtlasiE5RHW4 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiE5RHW4, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliE5RHW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 187PHBInterPro annotationAdd BLAST167

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2962 Eukaryota
ENOG410XQSH LUCA
GeneTreeiENSGT00390000014666
OMAiVVNFLIQ

Family and domain databases

CDDicd03406 SPFH_like_u3, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR033294 Erlin1/2
PANTHERiPTHR15351 PTHR15351, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
SMARTiView protein in SMART
SM00244 PHB, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E5RHW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQLGAVVAV ASSFFCASLF SAVHKIEEGH IGVYYRGGAL LTSTSGPGFH
60 70 80 90 100
LMLPFITSYK SVQTTLQTDE VKNVPCGTSG GVMIYFDRIE VVNFLVPNAV
110 120 130 140 150
YDIVKNYTAD YDKALIFNKI HHELNQFCSV HTLQEVYIEL FDQIDENLKL
160 170 180 190 200
ALQQDLTSMA PGLVIQAVRV TKPNIPEAIR RNYELMESEK TKLLIAAQKQ
210 220 230 240 250
KVVEKEAETE RKKALIEAEK VAQVAEITYG QKVMEKETEK KISEIEDAAF
260 270 280 290 300
LAREKAKADA ECYTAMKIAE ANKLKLTPEY LQLMKYKAIA SNSKIYFGKD
310 320 330
IPNMFMDSAG SVSKQFEGLA DKLSFGLEDE PLETATKE
Length:338
Mass (Da):37,725
Last modified:February 8, 2011 - v1
Checksum:i0322548FD58DB063
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O94905ERLN2_HUMAN
Erlin-2
ERLIN2 C8orf2, SPFH2, UNQ2441/PRO5003/PRO9924
339Annotation score:
E5RJ09E5RJ09_HUMAN
Erlin-2
ERLIN2
197Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei338Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138356 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000521644; ENSP00000429621; ENSG00000147475
UCSCiuc064lxs.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138356 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE5RHW4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE5RHW4, 1 interactor

Proteomic databases

EPDiE5RHW4
MaxQBiE5RHW4
PeptideAtlasiE5RHW4
PRIDEiE5RHW4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000521644; ENSP00000429621; ENSG00000147475
UCSCiuc064lxs.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000147475.14
HGNCiHGNC:1356 ERLIN2
OpenTargetsiENSG00000147475
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2962 Eukaryota
ENOG410XQSH LUCA
GeneTreeiENSGT00390000014666
OMAiVVNFLIQ

Gene expression databases

BgeeiENSG00000147475 Expressed in 219 organ(s), highest expression level in choroid plexus epithelium
ExpressionAtlasiE5RHW4 baseline and differential

Family and domain databases

CDDicd03406 SPFH_like_u3, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR033294 Erlin1/2
PANTHERiPTHR15351 PTHR15351, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
SMARTiView protein in SMART
SM00244 PHB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE5RHW4_HUMAN
AccessioniPrimary (citable) accession number: E5RHW4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 7, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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