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Protein
Submitted name:

Store-operated calcium entry-associated regulatory factor

Gene

SARAF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Store-operated calcium entry-associated regulatory factorImported
Gene namesi
Name:SARAFImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000133872.13
HGNCiHGNC:28789 SARAF

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133872

PTM / Processingi

Proteomic databases

MaxQBiE5RHW0
PeptideAtlasiE5RHW0
PRIDEiE5RHW0

Expressioni

Gene expression databases

BgeeiENSG00000133872 Expressed in 239 organ(s), highest expression level in frontal cortex
ExpressionAtlasiE5RHW0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE5RHW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IV9Z Eukaryota
ENOG4111IKY LUCA
GeneTreeiENSGT00390000013419

Family and domain databases

InterProiView protein in InterPro
IPR009567 SARAF
PANTHERiPTHR15929 PTHR15929, 1 hit
PfamiView protein in Pfam
PF06682 SARAF, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

E5RHW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLRDVKALT LHYDRYTTSR RLDPIPQLKC VGGTAGCDSY TPKVIQCQNK
60 70 80 90 100
GWDGYDVQWE CKTDLDIAYK FGKTVVSCEG YESSEDQYVL RGSCGLEYNL
110 120 130 140 150
DYTELGLQKL KESGKQHGFA SFSDYYYKWS SADSCNMSGL ITIVVLLGIA
160 170 180 190 200
FVVYKLFLSD GQYSPPPYSE YPPFSHRYQR FTNSAGPPPP GFKSEFTGPQ

NT
Length:202
Mass (Da):22,802
Last modified:February 8, 2011 - v1
Checksum:iA4584140EFE7BA68
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96BY9SARAF_HUMAN
Store-operated calcium entry-associ...
SARAF TMEM66, XTP3, HSPC035, NPD003, PSEC0019
339Annotation score:
H0YBH7H0YBH7_HUMAN
Store-operated calcium entry-associ...
SARAF
347Annotation score:
H0YAN9H0YAN9_HUMAN
Store-operated calcium entry-associ...
SARAF
218Annotation score:
H0YAZ1H0YAZ1_HUMAN
Store-operated calcium entry-associ...
SARAF
213Annotation score:
E5RFJ9E5RFJ9_HUMAN
Store-operated calcium entry-associ...
SARAF
147Annotation score:
E5RK07E5RK07_HUMAN
Store-operated calcium entry-associ...
SARAF
40Annotation score:
E5RJG8E5RJG8_HUMAN
Store-operated calcium entry-associ...
SARAF
36Annotation score:
E5RJV6E5RJV6_HUMAN
Store-operated calcium entry-associ...
SARAF
37Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei202Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC044849 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000522794; ENSP00000429630; ENSG00000133872
UCSCiuc064lro.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC044849 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE5RHW0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE5RHW0
PeptideAtlasiE5RHW0
PRIDEiE5RHW0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000522794; ENSP00000429630; ENSG00000133872
UCSCiuc064lro.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000133872.13
HGNCiHGNC:28789 SARAF
OpenTargetsiENSG00000133872
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IV9Z Eukaryota
ENOG4111IKY LUCA
GeneTreeiENSGT00390000013419

Miscellaneous databases

ChiTaRSiSARAF human

Gene expression databases

BgeeiENSG00000133872 Expressed in 239 organ(s), highest expression level in frontal cortex
ExpressionAtlasiE5RHW0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR009567 SARAF
PANTHERiPTHR15929 PTHR15929, 1 hit
PfamiView protein in Pfam
PF06682 SARAF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE5RHW0_HUMAN
AccessioniPrimary (citable) accession number: E5RHW0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 12, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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