UniProtKB - E5RHL2 (E5RHL2_HUMAN)
Protein
Submitted name:
Protein-tyrosine kinase 2-beta
Gene
PTK2B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: InterPro
GO - Biological processi
- regulation of actin cytoskeleton reorganization Source: InterPro
- regulation of angiogenesis Source: InterPro
- regulation of bone mineralization Source: InterPro
- regulation of cell adhesion Source: InterPro
- regulation of cell population proliferation Source: InterPro
- regulation of leukocyte chemotaxis Source: InterPro
- signal transduction Source: InterPro
Keywordsi
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Protein-tyrosine kinase 2-betaImported |
Gene namesi | Name:PTK2BImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9612, PTK2B |
VEuPathDBi | HostDB:ENSG00000120899.17 |
Subcellular locationi
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: InterPro
PTM / Processingi
Proteomic databases
MaxQBi | E5RHL2 |
PeptideAtlasi | E5RHL2 |
PRIDEi | E5RHL2 |
ProteomicsDBi | 16017 |
Expressioni
Gene expression databases
Bgeei | ENSG00000120899, Expressed in right hemisphere of cerebellum and 208 other tissues |
ExpressionAtlasi | E5RHL2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 68 | FERM_N_2InterPro annotationAdd BLAST | 30 |
Phylogenomic databases
GeneTreei | ENSGT00940000157269 |
HOGENOMi | CLU_2800653_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR041390, FADK_N IPR030610, PTK2B |
PANTHERi | PTHR24418:SF94, PTHR24418:SF94, 1 hit |
Pfami | View protein in Pfam PF18038, FERM_N_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
E5RHL2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGVSEPLSR VKLGTLRRPE GPAEPMVVVP VDVEKEDVRI LKVCFYSNSF
60
NPGKNFKLVK CTVQTEIR
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ14289 | FAK2_HUMAN | Protein-tyrosine kinase 2-beta | PTK2B FAK2, PYK2, RAFTK | 1,009 | Annotation score: | ||
C9JHV9 | C9JHV9_HUMAN | Protein-tyrosine kinase 2-beta | PTK2B | 213 | Annotation score: | ||
E5RJ77 | E5RJ77_HUMAN | Protein-tyrosine kinase 2-beta | PTK2B | 184 | Annotation score: | ||
H0YB74 | H0YB74_HUMAN | Protein-tyrosine kinase 2-beta | PTK2B | 194 | Annotation score: | ||
E5RK84 | E5RK84_HUMAN | Protein-tyrosine kinase 2-beta | PTK2B | 103 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 68 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010856 Genomic DNA No translation available. AC124649 Genomic DNA No translation available. AF311103 Genomic DNA No translation available. KC877228 Genomic DNA No translation available. KF458717 Genomic DNA No translation available. KF458718 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000522338; ENSP00000429694; ENSG00000120899 |
UCSCi | uc064lkm.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010856 Genomic DNA No translation available. AC124649 Genomic DNA No translation available. AF311103 Genomic DNA No translation available. KC877228 Genomic DNA No translation available. KF458717 Genomic DNA No translation available. KF458718 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | E5RHL2 |
PeptideAtlasi | E5RHL2 |
PRIDEi | E5RHL2 |
ProteomicsDBi | 16017 |
Protocols and materials databases
Antibodypediai | 3551, 985 antibodies |
Genome annotation databases
Ensembli | ENST00000522338; ENSP00000429694; ENSG00000120899 |
UCSCi | uc064lkm.1, human |
Organism-specific databases
HGNCi | HGNC:9612, PTK2B |
NIAGADSi | ENSG00000120899 |
OpenTargetsi | ENSG00000120899 |
VEuPathDBi | HostDB:ENSG00000120899.17 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157269 |
HOGENOMi | CLU_2800653_0_0_1 |
Miscellaneous databases
ChiTaRSi | PTK2B, human |
Gene expression databases
Bgeei | ENSG00000120899, Expressed in right hemisphere of cerebellum and 208 other tissues |
ExpressionAtlasi | E5RHL2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR041390, FADK_N IPR030610, PTK2B |
PANTHERi | PTHR24418:SF94, PTHR24418:SF94, 1 hit |
Pfami | View protein in Pfam PF18038, FERM_N_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E5RHL2_HUMAN | |
Accessioni | E5RHL2Primary (citable) accession number: E5RHL2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | February 10, 2021 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |