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Protein
Submitted name:

Homeobox-containing protein 1

Gene

HMBOX1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox-containing protein 1Imported
Gene namesi
Name:HMBOX1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147421.17
HGNCiHGNC:26137 HMBOX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147421

PTM / Processingi

Proteomic databases

MaxQBiE5RHH9
PeptideAtlasiE5RHH9

Expressioni

Gene expression databases

BgeeiENSG00000147421 Expressed in 225 organ(s), highest expression level in heart
ExpressionAtlasiE5RHH9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE5RHH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 112HNF-1_NInterPro annotationAdd BLAST88

Phylogenomic databases

eggNOGiENOG410IIRR Eukaryota
ENOG4111F86 LUCA
GeneTreeiENSGT00920000149039

Family and domain databases

InterProiView protein in InterPro
IPR006899 HNF-1_N
PfamiView protein in Pfam
PF04814 HNF-1_N, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E5RHH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSSFPVVLL ETMSHYTDEP RFTIEQIDLL QRLRRTGMTK HEILHALETL
60 70 80 90 100
DRLDQEHSDK FGRRSSYGGS SYGNSTNNVP ASSSTATAST QTQHSGMSPS
110
PSNSYDTSPQ PCTTNQNG
Length:118
Mass (Da):13,024
Last modified:February 8, 2011 - v1
Checksum:iBC645F3C7829E44A
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6NT76HMBX1_HUMAN
Homeobox-containing protein 1
HMBOX1 HOT1, TAH1
420Annotation score:
H0YKJ1H0YKJ1_HUMAN
Homeobox-containing protein 1
HMBOX1
396Annotation score:
E5RGZ2E5RGZ2_HUMAN
Homeobox-containing protein 1
HMBOX1
386Annotation score:
H0YLF2H0YLF2_HUMAN
Homeobox-containing protein 1
HMBOX1
364Annotation score:
H0YBM8H0YBM8_HUMAN
Homeobox-containing protein 1
HMBOX1
45Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei118Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC040975 Genomic DNA No translation available.
AC091558 Genomic DNA No translation available.
AC108449 Genomic DNA No translation available.
KC877224 Genomic DNA No translation available.
KF458725 Genomic DNA No translation available.
KF458730 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000519662; ENSP00000429767; ENSG00000147421
UCSCiuc064lpw.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC040975 Genomic DNA No translation available.
AC091558 Genomic DNA No translation available.
AC108449 Genomic DNA No translation available.
KC877224 Genomic DNA No translation available.
KF458725 Genomic DNA No translation available.
KF458730 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE5RHH9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE5RHH9
PeptideAtlasiE5RHH9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000519662; ENSP00000429767; ENSG00000147421
UCSCiuc064lpw.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000147421.17
HGNCiHGNC:26137 HMBOX1
OpenTargetsiENSG00000147421
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIRR Eukaryota
ENOG4111F86 LUCA
GeneTreeiENSGT00920000149039

Miscellaneous databases

ChiTaRSiHMBOX1 human

Gene expression databases

BgeeiENSG00000147421 Expressed in 225 organ(s), highest expression level in heart
ExpressionAtlasiE5RHH9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR006899 HNF-1_N
PfamiView protein in Pfam
PF04814 HNF-1_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE5RHH9_HUMAN
AccessioniPrimary (citable) accession number: E5RHH9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 12, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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