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UniProtKB - E5RGU3 (E5RGU3_HUMAN)
Protein
Submitted name:
Catenin alpha-1
Gene
CTNNA1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin filament binding Source: InterPro
- cadherin binding Source: InterPro
GO - Biological processi
- brain morphogenesis Source: InterPro
- cell adhesion Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Catenin alpha-1Imported |
Gene namesi | Name:CTNNA1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2509, CTNNA1 |
VEuPathDBi | HostDB:ENSG00000044115 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- adherens junction Source: InterPro
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000044115, Expressed in corpus callosum and 250 other tissues |
ExpressionAtlasi | E5RGU3, baseline and differential |
Interactioni
GO - Molecular functioni
- actin filament binding Source: InterPro
- cadherin binding Source: InterPro
Family & Domainsi
Sequence similaritiesi
Belongs to the vinculin/alpha-catenin family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT01030000234543 |
OMAi | QXNHILE |
Family and domain databases
InterProi | View protein in InterPro IPR036723, Alpha-catenin/vinculin-like_sf IPR030046, CTNNA2 IPR006077, Vinculin/catenin |
PANTHERi | PTHR18914:SF23, PTHR18914:SF23, 1 hit |
Pfami | View protein in Pfam PF01044, Vinculin, 1 hit |
SUPFAMi | SSF47220, SSF47220, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 28 potential isoforms that are computationally mapped.Show allAlign All
E5RGU3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKKTRDLRR QLRKAVMDHV SDSFLETNVP LLVLIEAAKN GNEKEVKEYA
60 70
QVFREHANKL IEVANLACSI S
Computationally mapped potential isoform sequencesi
There are 28 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP35221 | CTNA1_HUMAN | Catenin alpha-1 | CTNNA1 | 906 | Annotation score: | ||
G3XAM7 | G3XAM7_HUMAN | Catenin (Cadherin-associated protei... | CTNNA1 hCG_1782385 | 841 | Annotation score: | ||
E5RIB1 | E5RIB1_HUMAN | Catenin alpha-1 | CTNNA1 | 215 | Annotation score: | ||
E5RJ41 | E5RJ41_HUMAN | Catenin alpha-1 | CTNNA1 | 161 | Annotation score: | ||
E5RGY7 | E5RGY7_HUMAN | Catenin alpha-1 | CTNNA1 | 136 | Annotation score: | ||
E5RG03 | E5RG03_HUMAN | Catenin alpha-1 | CTNNA1 | 156 | Annotation score: | ||
E5RGD2 | E5RGD2_HUMAN | Catenin alpha-1 | CTNNA1 | 128 | Annotation score: | ||
E5RFK9 | E5RFK9_HUMAN | Catenin alpha-1 | CTNNA1 | 105 | Annotation score: | ||
E5RGY6 | E5RGY6_HUMAN | Catenin alpha-1 | CTNNA1 | 139 | Annotation score: | ||
E5RHV7 | E5RHV7_HUMAN | Catenin alpha-1 | CTNNA1 | 123 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 71 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010453 Genomic DNA No translation available. AC011405 Genomic DNA No translation available. AC034243 Genomic DNA No translation available. AC113340 Genomic DNA No translation available. KF458015 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000521683; ENSP00000430981; ENSG00000044115 |
UCSCi | uc063hnp.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010453 Genomic DNA No translation available. AC011405 Genomic DNA No translation available. AC034243 Genomic DNA No translation available. AC113340 Genomic DNA No translation available. KF458015 Genomic DNA No translation available. |
3D structure databases
SMRi | E5RGU3 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E5RGU3 |
PeptideAtlasi | E5RGU3 |
ProteomicsDBi | 15779 |
Protocols and materials databases
Antibodypediai | 3431, 789 antibodies from 44 providers |
Genome annotation databases
Ensembli | ENST00000521683; ENSP00000430981; ENSG00000044115 |
UCSCi | uc063hnp.1, human |
Organism-specific databases
HGNCi | HGNC:2509, CTNNA1 |
OpenTargetsi | ENSG00000044115 |
VEuPathDBi | HostDB:ENSG00000044115 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01030000234543 |
OMAi | QXNHILE |
Miscellaneous databases
ChiTaRSi | CTNNA1, human |
Gene expression databases
Bgeei | ENSG00000044115, Expressed in corpus callosum and 250 other tissues |
ExpressionAtlasi | E5RGU3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR036723, Alpha-catenin/vinculin-like_sf IPR030046, CTNNA2 IPR006077, Vinculin/catenin |
PANTHERi | PTHR18914:SF23, PTHR18914:SF23, 1 hit |
Pfami | View protein in Pfam PF01044, Vinculin, 1 hit |
SUPFAMi | SSF47220, SSF47220, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E5RGU3_HUMAN | |
Accessioni | E5RGU3Primary (citable) accession number: E5RGU3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | January 19, 2022 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |