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Protein
Submitted name:

Transcription factor 7

Gene

TCF7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor 7Imported
Gene namesi
Name:TCF7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000081059.19
HGNCiHGNC:11639 TCF7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000081059

PTM / Processingi

Proteomic databases

PeptideAtlasiE5RG34
PRIDEiE5RG34

Expressioni

Gene expression databases

BgeeiENSG00000081059 Expressed in 236 organ(s), highest expression level in thymus
ExpressionAtlasiE5RG34 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE5RG34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 97CTNNB1_bindingInterPro annotationAdd BLAST97

Phylogenomic databases

GeneTreeiENSGT00390000009964

Family and domain databases

InterProiView protein in InterPro
IPR013558 CTNNB1-bd_N
IPR024940 TCF/LEF
IPR028785 Tcf7
PANTHERiPTHR10373 PTHR10373, 1 hit
PTHR10373:SF33 PTHR10373:SF33, 1 hit
PfamiView protein in Pfam
PF08347 CTNNB1_binding, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

E5RG34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYKETVYSAF NLLMHYPPPS GAGQHPQPQP PLHKANQPPH GVPQLSLYEH
60 70 80 90 100
FNSPHPTPAP ADISQKQVHR PLQTPDLSGF YSLTSGSMGQ LPHTVSWPSP
110 120 130 140 150
PLYPLSPSCG YRQHFPAPTA APGAPYPRFT HPSLMLGSGV PGHPAAIPHP

AIV
Length:153
Mass (Da):16,492
Last modified:February 8, 2011 - v1
Checksum:i8A3270AA251D840B
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P36402TCF7_HUMAN
Transcription factor 7
TCF7 TCF1
384Annotation score:
B7WNT5B7WNT5_HUMAN
Transcription factor 7 (T-cell spec...
TCF7 hCG_16589
481Annotation score:
E5RHL1E5RHL1_HUMAN
Transcription factor 7
TCF7
143Annotation score:
E5RG75E5RG75_HUMAN
Transcription factor 7
TCF7
147Annotation score:
H0YAR8H0YAR8_HUMAN
Transcription factor 7
TCF7
147Annotation score:
H0YBC8H0YBC8_HUMAN
Transcription factor 7
TCF7
204Annotation score:
E5RJ51E5RJ51_HUMAN
Transcription factor 7
TCF7
122Annotation score:
E5RGQ1E5RGQ1_HUMAN
Transcription factor 7
TCF7
167Annotation score:
H0YBM1H0YBM1_HUMAN
Transcription factor 7
TCF7
71Annotation score:
H0YBP2H0YBP2_HUMAN
Transcription factor 7
TCF7
105Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei153Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008608 Genomic DNA No translation available.
AC011336 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000522375; ENSP00000427870; ENSG00000081059
UCSCiuc063gzn.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008608 Genomic DNA No translation available.
AC011336 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE5RG34
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiE5RG34
PRIDEiE5RG34

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000522375; ENSP00000427870; ENSG00000081059
UCSCiuc063gzn.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000081059.19
HGNCiHGNC:11639 TCF7
OpenTargetsiENSG00000081059
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000009964

Miscellaneous databases

ChiTaRSiTCF7 human

Gene expression databases

BgeeiENSG00000081059 Expressed in 236 organ(s), highest expression level in thymus
ExpressionAtlasiE5RG34 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013558 CTNNB1-bd_N
IPR024940 TCF/LEF
IPR028785 Tcf7
PANTHERiPTHR10373 PTHR10373, 1 hit
PTHR10373:SF33 PTHR10373:SF33, 1 hit
PfamiView protein in Pfam
PF08347 CTNNB1_binding, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE5RG34_HUMAN
AccessioniPrimary (citable) accession number: E5RG34
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 12, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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