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Protein

Putative serine protease 46

Gene

PRSS46P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83Charge relay systemBy similarity1
Active sitei128Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.394

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine protease 46 (EC:3.4.21.-)
Alternative name(s):
Serine protease 46 pseudogeneImported
Gene namesi
Name:PRSS46PImported
Synonyms:PRSS46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000261603.1
HGNCiHGNC:37325 PRSS46P
neXtProtiNX_E5RG02

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiPRSS46

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004183321 – 174Putative serine protease 46Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 84PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiE5RG02
PRIDEiE5RG02
ProteomicsDBi15511

Expressioni

Gene expression databases

BgeeiENSG00000261603 Expressed in 67 organ(s), highest expression level in right testis

Interactioni

Protein-protein interaction databases

BioGridi939023, 1 interactor
STRINGi9606.ENSP00000430307

Structurei

3D structure databases

ProteinModelPortaliE5RG02
SMRiE5RG02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 174Peptidase S1PROSITE-ProRule annotationAdd BLAST132

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
InParanoidiE5RG02
OMAiVMVGVHQ
OrthoDBiEOG091G0DF7

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

E5RG02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACGPGDLQS LTSPLSSARL DYQPSIEGPW LRACGQTNVS CRVVKGKLVE
60 70 80 90 100
VGKWPWQVSI LFLGTYICSG SLIHHQWVLT AAHCLQRFKD LSLYSVMVGV
110 120 130 140 150
HQRPENSTQL PLTRMVIHKD FSNLMSQDIA LLKLRDSISW SPFVQPVCLP
160 170
NIKFKPSIGS MCWVIGWGTT GKKG
Length:174
Mass (Da):19,341
Last modified:February 8, 2011 - v1
Checksum:iC81897F137B09408
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134504 Genomic DNA No translation available.
RefSeqiNP_001192200.1, NM_001205271.1
UniGeneiHs.673244

Genome annotation databases

UCSCiuc021wxf.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134504 Genomic DNA No translation available.
RefSeqiNP_001192200.1, NM_001205271.1
UniGeneiHs.673244

3D structure databases

ProteinModelPortaliE5RG02
SMRiE5RG02
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi939023, 1 interactor
STRINGi9606.ENSP00000430307

Protein family/group databases

MEROPSiS01.394

Polymorphism and mutation databases

BioMutaiPRSS46

Proteomic databases

PaxDbiE5RG02
PRIDEiE5RG02
ProteomicsDBi15511

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc021wxf.2 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000261603.1
GeneCardsiPRSS46P
HGNCiHGNC:37325 PRSS46P
neXtProtiNX_E5RG02
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
InParanoidiE5RG02
OMAiVMVGVHQ
OrthoDBiEOG091G0DF7

Miscellaneous databases

GenomeRNAii100287362
PROiPR:E5RG02

Gene expression databases

BgeeiENSG00000261603 Expressed in 67 organ(s), highest expression level in right testis

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRS46_HUMAN
AccessioniPrimary (citable) accession number: E5RG02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: February 8, 2011
Last modified: September 12, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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