UniProtKB - E5RFG9 (E5RFG9_HUMAN)
Protein
Carboxylic ester hydrolase
Gene
CES5A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- hydrolase activity Source: UniProtKB-KW
Keywordsi
Molecular function | HydrolaseUniRule annotation |
Protein family/group databases
ESTHERi | human-CES5A, Carb_B_Chordata |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CES5AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000159398.15 |
HGNCi | HGNC:26459, CES5A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | UniRule annotationAdd BLAST | 20 | |
ChainiPRO_5005128174 | 21 – 545 | Carboxylic ester hydrolaseUniRule annotationAdd BLAST | 525 |
Proteomic databases
PeptideAtlasi | E5RFG9 |
PRIDEi | E5RFG9 |
ProteomicsDBi | 15340 |
Expressioni
Gene expression databases
Bgeei | ENSG00000159398, Expressed in cauda epididymis and 53 other tissues |
ExpressionAtlasi | E5RFG9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 99 | COesteraseInterPro annotationAdd BLAST | 69 | |
Domaini | 108 – 509 | COesteraseInterPro annotationAdd BLAST | 402 |
Sequence similaritiesi
Belongs to the type-B carboxylesterase/lipase family.UniRule annotation
Keywords - Domaini
SignalUniRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000161596 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS |
Pfami | View protein in Pfam PF00135, COesterase, 2 hits |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
E5RFG9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGNWVHPGQ ILIWAIWVLA APTKGPSAEG PQRNTRLGWI QGKQVTVLGS
60 70 80 90 100
PVPVNVFLGV PFAAPPLGSL RFTNPQPASP WDNLREATSY PNLCLQNSEW
110 120 130 140 150
LLLDQHMLKV LVWFPGGAFK TGSASIFDGS ALAAYEDVLV VVVQYRLGIF
160 170 180 190 200
GFFTTWDQHA PGNWAFKDQV AALSWVQKNI EFFGGDPSSV TIFGESAGAI
210 220 230 240 250
SVSSLILSPM AKGLFHKAIM ESGVAIIPYL EAHDYEKSED LQVVAHFCGN
260 270 280 290 300
NASDSEALLR CLRTKPSKEL LTLSQKTKSF TRVVDGAFFP NEPLDLLSQK
310 320 330 340 350
AFKAIPSIIG VNNHECGFLL PMKEAPEILS GSNKSLALHL IQNILHIPPQ
360 370 380 390 400
YLHLVANEYF HDKHSLTEIR DSLLDLLGDV FFVVPALITA RYHRDAGAPV
410 420 430 440 450
YFYEFRHRPQ CFEDTKPAFV KADHADEVRF VFGGAFLKGD IVMFEGATEE
460 470 480 490 500
EKLLSRKMMK YWATFARTGN PNGNDLSLWP AYNLTEQYLQ LDLNMSLGQR
510 520 530 540
LKEPRVDFWT STIPLILSAS DMLHSPLSSL TFLSLLQPFF FFCAP
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6NT32 | EST5A_HUMAN | Carboxylesterase 5A | CES5A CES7 | 575 | Annotation score: | ||
A0A140TA75 | A0A140TA75_HUMAN | Carboxylic ester hydrolase | CES5A | 604 | Annotation score: | ||
A0A140TA60 | A0A140TA60_HUMAN | Carboxylic ester hydrolase | CES5A | 545 | Annotation score: | ||
A0A140TA78 | A0A140TA78_HUMAN | Carboxylic ester hydrolase | CES5A | 525 | Annotation score: | ||
A0A140TA61 | A0A140TA61_HUMAN | Carboxylic ester hydrolase | CES5A | 575 | Annotation score: | ||
A0A140TA72 | A0A140TA72_HUMAN | Carboxylic ester hydrolase | CES5A | 469 | Annotation score: | ||
I3NI11 | I3NI11_HUMAN | Carboxylesterase 5A | CES5A | 78 | Annotation score: | ||
F5H0J7 | F5H0J7_HUMAN | Carboxylesterase 5A | CES5A | 75 | Annotation score: | ||
A0A0J9YW16 | A0A0J9YW16_HUMAN | Carboxylesterase 5A | CES5A | 355 | Annotation score: | ||
A0A140TA65 | A0A140TA65_HUMAN | Carboxylesterase 5A | CES5A | 355 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007335 Genomic DNA No translation available. AC147362 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000520435; ENSP00000428887; ENSG00000159398 |
UCSCi | uc059uja.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007335 Genomic DNA No translation available. AC147362 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
ESTHERi | human-CES5A, Carb_B_Chordata |
Proteomic databases
PeptideAtlasi | E5RFG9 |
PRIDEi | E5RFG9 |
ProteomicsDBi | 15340 |
Protocols and materials databases
Antibodypediai | 28532, 112 antibodies |
Genome annotation databases
Ensembli | ENST00000520435; ENSP00000428887; ENSG00000159398 |
UCSCi | uc059uja.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000159398.15 |
HGNCi | HGNC:26459, CES5A |
OpenTargetsi | ENSG00000159398 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161596 |
Miscellaneous databases
ChiTaRSi | CES5A, human |
Gene expression databases
Bgeei | ENSG00000159398, Expressed in cauda epididymis and 53 other tissues |
ExpressionAtlasi | E5RFG9, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS |
Pfami | View protein in Pfam PF00135, COesterase, 2 hits |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E5RFG9_HUMAN | |
Accessioni | E5RFG9Primary (citable) accession number: E5RFG9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | October 7, 2020 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |