UniProtKB - E5KTA6 (E5KTA6_HUMAN)
Protein
Uracil-DNA glycosylase
Gene
UNG
Organism
Homo sapiens (Human)
Status
Functioni
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation
Catalytic activityi
- Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation EC:3.2.2.27
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 145 | Proton acceptorUniRule annotation | 1 |
GO - Molecular functioni
- uracil DNA N-glycosylase activity Source: UniProtKB-UniRule
GO - Biological processi
- base-excision repair Source: UniProtKB-UniRule
Keywordsi
Molecular function | HydrolaseUniRule annotationARBA annotation |
Biological process | DNA damage, DNA repairUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)Short name: UDGUniRule annotation |
Gene namesi | Name:UNGUniRule annotationImported Synonyms:UNG1UniRule annotation ORF Names:hCG_38494Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000076248.10 |
Subcellular locationi
Mitochondrion
- Mitochondrion UniRule annotation
Nucleus
- Nucleus UniRule annotation
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionUniRule annotation, NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000076248, Expressed in secondary oocyte and 241 other tissues |
Interactioni
Subunit structurei
Monomer.
Interacts with FAM72A.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 130 – 291 | UDGInterPro annotationAdd BLAST | 162 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 40 – 59 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotationARBA annotation
Phylogenomic databases
OMAi | PDNGYLM |
Family and domain databases
CDDi | cd10027, UDG_F1, 1 hit |
Gene3Di | 3.40.470.10, 1 hit |
HAMAPi | MF_00148, UDG, 1 hit |
InterProi | View protein in InterPro IPR002043, UDG_fam1 IPR018085, Ura-DNA_Glyclase_AS IPR005122, Uracil-DNA_glycosylase-like IPR036895, Uracil-DNA_glycosylase-like_sf |
PANTHERi | PTHR11264, PTHR11264, 1 hit |
Pfami | View protein in Pfam PF03167, UDG, 1 hit |
SMARTi | View protein in SMART SM00986, UDG, 1 hit |
SUPFAMi | SSF52141, SSF52141, 1 hit |
TIGRFAMsi | TIGR00628, ung, 1 hit |
PROSITEi | View protein in PROSITE PS00130, U_DNA_GLYCOSYLASE, 1 hit |
i Sequence
Sequence statusi: Complete.
E5KTA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVFCLGPWG LGRKLRTPGK GPLQLLSRLC GDHLQAIPAK KAPAGQEEPG
60 70 80 90 100
TPPSSPLSAE QLDRIQRNKA AALLRLAARN VPVGFGESWK KHLSGEFGKP
110 120 130 140 150
YFIKLMGFVA EERKHYTVYP PPHQVFTWTQ MCDIKDVKVV ILGQDPYHGP
160 170 180 190 200
NQAHGLCFSV QRPVPPPPSL ENIYKELSTD IEDFVHPGHG DLSGWAKQGV
210 220 230 240 250
LLLNAVLTVR AHQANSHKER GWEQFTDAVV SWLNQNSNGL VFLLWGSYAQ
260 270 280 290 300
KKGSAIDRKR HHVLQTAHPS PLSVYRGFFG CRHFSKTNEL LQKSGKKPID
WKEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ206226 Genomic DNA Translation: ADP92135.1 HQ206227 Genomic DNA Translation: ADP92137.1 HQ206228 Genomic DNA Translation: ADP92139.1 HQ206229 Genomic DNA Translation: ADP92141.1 HQ206230 Genomic DNA Translation: ADP92143.1 HQ206231 Genomic DNA Translation: ADP92145.1 HQ206232 Genomic DNA Translation: ADP92147.1 HQ206233 Genomic DNA Translation: ADP92149.1 HQ206234 Genomic DNA Translation: ADP92151.1 HQ206235 Genomic DNA Translation: ADP92153.1 HQ206236 Genomic DNA Translation: ADP92155.1 HQ206237 Genomic DNA Translation: ADP92157.1 HQ206238 Genomic DNA Translation: ADP92159.1 HQ206239 Genomic DNA Translation: ADP92161.1 HQ206240 Genomic DNA Translation: ADP92163.1 HQ206241 Genomic DNA Translation: ADP92165.1 HQ206242 Genomic DNA Translation: ADP92167.1 HQ206243 Genomic DNA Translation: ADP92169.1 HQ206244 Genomic DNA Translation: ADP92171.1 HQ206245 Genomic DNA Translation: ADP92173.1 HQ206246 Genomic DNA Translation: ADP92175.1 HQ206247 Genomic DNA Translation: ADP92177.1 HQ206248 Genomic DNA Translation: ADP92179.1 HQ206249 Genomic DNA Translation: ADP92181.1 HQ206250 Genomic DNA Translation: ADP92183.1 HQ206251 Genomic DNA Translation: ADP92185.1 HQ206252 Genomic DNA Translation: ADP92187.1 HQ206253 Genomic DNA Translation: ADP92189.1 HQ206254 Genomic DNA Translation: ADP92191.1 HQ206255 Genomic DNA Translation: ADP92193.1 HQ206256 Genomic DNA Translation: ADP92195.1 HQ206257 Genomic DNA Translation: ADP92197.1 HQ206258 Genomic DNA Translation: ADP92199.1 HQ206259 Genomic DNA Translation: ADP92201.1 HQ206260 Genomic DNA Translation: ADP92203.1 HQ206261 Genomic DNA Translation: ADP92205.1 HQ206262 Genomic DNA Translation: ADP92207.1 HQ206263 Genomic DNA Translation: ADP92209.1 HQ206264 Genomic DNA Translation: ADP92211.1 HQ206265 Genomic DNA Translation: ADP92213.1 CH471054 Genomic DNA Translation: EAW97848.1 CH471054 Genomic DNA Translation: EAW97850.1 |
RefSeqi | NP_003353.1, NM_003362.3 |
Genome annotation databases
GeneIDi | 7374 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ206226 Genomic DNA Translation: ADP92135.1 HQ206227 Genomic DNA Translation: ADP92137.1 HQ206228 Genomic DNA Translation: ADP92139.1 HQ206229 Genomic DNA Translation: ADP92141.1 HQ206230 Genomic DNA Translation: ADP92143.1 HQ206231 Genomic DNA Translation: ADP92145.1 HQ206232 Genomic DNA Translation: ADP92147.1 HQ206233 Genomic DNA Translation: ADP92149.1 HQ206234 Genomic DNA Translation: ADP92151.1 HQ206235 Genomic DNA Translation: ADP92153.1 HQ206236 Genomic DNA Translation: ADP92155.1 HQ206237 Genomic DNA Translation: ADP92157.1 HQ206238 Genomic DNA Translation: ADP92159.1 HQ206239 Genomic DNA Translation: ADP92161.1 HQ206240 Genomic DNA Translation: ADP92163.1 HQ206241 Genomic DNA Translation: ADP92165.1 HQ206242 Genomic DNA Translation: ADP92167.1 HQ206243 Genomic DNA Translation: ADP92169.1 HQ206244 Genomic DNA Translation: ADP92171.1 HQ206245 Genomic DNA Translation: ADP92173.1 HQ206246 Genomic DNA Translation: ADP92175.1 HQ206247 Genomic DNA Translation: ADP92177.1 HQ206248 Genomic DNA Translation: ADP92179.1 HQ206249 Genomic DNA Translation: ADP92181.1 HQ206250 Genomic DNA Translation: ADP92183.1 HQ206251 Genomic DNA Translation: ADP92185.1 HQ206252 Genomic DNA Translation: ADP92187.1 HQ206253 Genomic DNA Translation: ADP92189.1 HQ206254 Genomic DNA Translation: ADP92191.1 HQ206255 Genomic DNA Translation: ADP92193.1 HQ206256 Genomic DNA Translation: ADP92195.1 HQ206257 Genomic DNA Translation: ADP92197.1 HQ206258 Genomic DNA Translation: ADP92199.1 HQ206259 Genomic DNA Translation: ADP92201.1 HQ206260 Genomic DNA Translation: ADP92203.1 HQ206261 Genomic DNA Translation: ADP92205.1 HQ206262 Genomic DNA Translation: ADP92207.1 HQ206263 Genomic DNA Translation: ADP92209.1 HQ206264 Genomic DNA Translation: ADP92211.1 HQ206265 Genomic DNA Translation: ADP92213.1 CH471054 Genomic DNA Translation: EAW97848.1 CH471054 Genomic DNA Translation: EAW97850.1 |
RefSeqi | NP_003353.1, NM_003362.3 |
3D structure databases
SMRi | E5KTA6 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 3173, 507 antibodies |
DNASUi | 7374 |
Genome annotation databases
GeneIDi | 7374 |
Organism-specific databases
CTDi | 7374 |
EuPathDBi | HostDB:ENSG00000076248.10 |
Phylogenomic databases
OMAi | PDNGYLM |
Miscellaneous databases
BioGRID-ORCSi | 7374, 9 hits in 849 CRISPR screens |
ChiTaRSi | UNG, human |
GenomeRNAii | 7374 |
Gene expression databases
Bgeei | ENSG00000076248, Expressed in secondary oocyte and 241 other tissues |
Family and domain databases
CDDi | cd10027, UDG_F1, 1 hit |
Gene3Di | 3.40.470.10, 1 hit |
HAMAPi | MF_00148, UDG, 1 hit |
InterProi | View protein in InterPro IPR002043, UDG_fam1 IPR018085, Ura-DNA_Glyclase_AS IPR005122, Uracil-DNA_glycosylase-like IPR036895, Uracil-DNA_glycosylase-like_sf |
PANTHERi | PTHR11264, PTHR11264, 1 hit |
Pfami | View protein in Pfam PF03167, UDG, 1 hit |
SMARTi | View protein in SMART SM00986, UDG, 1 hit |
SUPFAMi | SSF52141, SSF52141, 1 hit |
TIGRFAMsi | TIGR00628, ung, 1 hit |
PROSITEi | View protein in PROSITE PS00130, U_DNA_GLYCOSYLASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E5KTA6_HUMAN | |
Accessioni | E5KTA6Primary (citable) accession number: E5KTA6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |