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Entry version 90 (02 Dec 2020)
Sequence version 1 (08 Feb 2011)
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Protein

Uracil-DNA glycosylase

Gene

UNG

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei154Proton acceptorUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseUniRule annotationARBA annotation
Biological processDNA damage, DNA repairUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UNGUniRule annotationImported
Synonyms:UNG1UniRule annotation
ORF Names:hCG_38494Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000076248.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation, NucleusUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E5KTA5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000076248, Expressed in secondary oocyte and 241 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts with FAM72A.

UniRule annotation

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
E5KTA5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E5KTA5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini139 – 300UDGInterPro annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 68DisorderedSequence analysisAdd BLAST68

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotationARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_032162_2_1_1

Database of Orthologous Groups

More...
OrthoDBi
832568at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10027, UDG_F1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.470.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00148, UDG, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002043, UDG_fam1
IPR018085, Ura-DNA_Glyclase_AS
IPR005122, Uracil-DNA_glycosylase-like
IPR036895, Uracil-DNA_glycosylase-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11264, PTHR11264, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03167, UDG, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00986, UDG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52141, SSF52141, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00628, ung, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00130, U_DNA_GLYCOSYLASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E5KTA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIGQKTLYSF FSPSPARKRH APSPEPAVQG TGVAGVPEES GDAAAIPAKK
60 70 80 90 100
APAGQEEPGT PPSSPLSAEQ LDRIQRNKAA ALLRLAARNV PVGFGESWKK
110 120 130 140 150
HLSGEFGKPY FIKLMGFVAE ERKHYTVYPP PHQVFTWTQM CDIKDVKVVI
160 170 180 190 200
LGQDPYHGPN QAHGLCFSVQ RPVPPPPSLE NIYKELSTDI EDFVHPGHGD
210 220 230 240 250
LSGWAKQGVL LLNAVLTVRA HQANSHKERG WEQFTDAVVS WLNQNSNGLV
260 270 280 290 300
FLLWGSYAQK KGSAIDRKRH HVLQTAHPSP LSVYRGFFGC RHFSKTNELL
310
QKSGKKPIDW KEL
Length:313
Mass (Da):34,645
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4B27E6198AFE9C0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HQ206226 Genomic DNA Translation: ADP92134.1
HQ206227 Genomic DNA Translation: ADP92136.1
HQ206228 Genomic DNA Translation: ADP92138.1
HQ206229 Genomic DNA Translation: ADP92140.1
HQ206230 Genomic DNA Translation: ADP92142.1
HQ206231 Genomic DNA Translation: ADP92144.1
HQ206232 Genomic DNA Translation: ADP92146.1
HQ206233 Genomic DNA Translation: ADP92148.1
HQ206234 Genomic DNA Translation: ADP92150.1
HQ206235 Genomic DNA Translation: ADP92152.1
HQ206236 Genomic DNA Translation: ADP92154.1
HQ206237 Genomic DNA Translation: ADP92156.1
HQ206238 Genomic DNA Translation: ADP92158.1
HQ206239 Genomic DNA Translation: ADP92160.1
HQ206240 Genomic DNA Translation: ADP92162.1
HQ206241 Genomic DNA Translation: ADP92164.1
HQ206242 Genomic DNA Translation: ADP92166.1
HQ206243 Genomic DNA Translation: ADP92168.1
HQ206244 Genomic DNA Translation: ADP92170.1
HQ206245 Genomic DNA Translation: ADP92172.1
HQ206246 Genomic DNA Translation: ADP92174.1
HQ206247 Genomic DNA Translation: ADP92176.1
HQ206248 Genomic DNA Translation: ADP92178.1
HQ206249 Genomic DNA Translation: ADP92180.1
HQ206250 Genomic DNA Translation: ADP92182.1
HQ206251 Genomic DNA Translation: ADP92184.1
HQ206252 Genomic DNA Translation: ADP92186.1
HQ206253 Genomic DNA Translation: ADP92188.1
HQ206254 Genomic DNA Translation: ADP92190.1
HQ206255 Genomic DNA Translation: ADP92192.1
HQ206256 Genomic DNA Translation: ADP92194.1
HQ206257 Genomic DNA Translation: ADP92196.1
HQ206258 Genomic DNA Translation: ADP92198.1
HQ206259 Genomic DNA Translation: ADP92200.1
HQ206260 Genomic DNA Translation: ADP92202.1
HQ206261 Genomic DNA Translation: ADP92204.1
HQ206262 Genomic DNA Translation: ADP92206.1
HQ206263 Genomic DNA Translation: ADP92208.1
HQ206264 Genomic DNA Translation: ADP92210.1
HQ206265 Genomic DNA Translation: ADP92212.1
CH471054 Genomic DNA Translation: EAW97849.1

NCBI Reference Sequences

More...
RefSeqi
NP_550433.1, NM_080911.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7374

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7374

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ206226 Genomic DNA Translation: ADP92134.1
HQ206227 Genomic DNA Translation: ADP92136.1
HQ206228 Genomic DNA Translation: ADP92138.1
HQ206229 Genomic DNA Translation: ADP92140.1
HQ206230 Genomic DNA Translation: ADP92142.1
HQ206231 Genomic DNA Translation: ADP92144.1
HQ206232 Genomic DNA Translation: ADP92146.1
HQ206233 Genomic DNA Translation: ADP92148.1
HQ206234 Genomic DNA Translation: ADP92150.1
HQ206235 Genomic DNA Translation: ADP92152.1
HQ206236 Genomic DNA Translation: ADP92154.1
HQ206237 Genomic DNA Translation: ADP92156.1
HQ206238 Genomic DNA Translation: ADP92158.1
HQ206239 Genomic DNA Translation: ADP92160.1
HQ206240 Genomic DNA Translation: ADP92162.1
HQ206241 Genomic DNA Translation: ADP92164.1
HQ206242 Genomic DNA Translation: ADP92166.1
HQ206243 Genomic DNA Translation: ADP92168.1
HQ206244 Genomic DNA Translation: ADP92170.1
HQ206245 Genomic DNA Translation: ADP92172.1
HQ206246 Genomic DNA Translation: ADP92174.1
HQ206247 Genomic DNA Translation: ADP92176.1
HQ206248 Genomic DNA Translation: ADP92178.1
HQ206249 Genomic DNA Translation: ADP92180.1
HQ206250 Genomic DNA Translation: ADP92182.1
HQ206251 Genomic DNA Translation: ADP92184.1
HQ206252 Genomic DNA Translation: ADP92186.1
HQ206253 Genomic DNA Translation: ADP92188.1
HQ206254 Genomic DNA Translation: ADP92190.1
HQ206255 Genomic DNA Translation: ADP92192.1
HQ206256 Genomic DNA Translation: ADP92194.1
HQ206257 Genomic DNA Translation: ADP92196.1
HQ206258 Genomic DNA Translation: ADP92198.1
HQ206259 Genomic DNA Translation: ADP92200.1
HQ206260 Genomic DNA Translation: ADP92202.1
HQ206261 Genomic DNA Translation: ADP92204.1
HQ206262 Genomic DNA Translation: ADP92206.1
HQ206263 Genomic DNA Translation: ADP92208.1
HQ206264 Genomic DNA Translation: ADP92210.1
HQ206265 Genomic DNA Translation: ADP92212.1
CH471054 Genomic DNA Translation: EAW97849.1
RefSeqiNP_550433.1, NM_080911.2

3D structure databases

SMRiE5KTA5
ModBaseiSearch...

Chemistry databases

BindingDBiE5KTA5

Proteomic databases

PRIDEiE5KTA5

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3173, 507 antibodies

The DNASU plasmid repository

More...
DNASUi
7374

Genome annotation databases

GeneIDi7374
KEGGihsa:7374

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7374
EuPathDBiHostDB:ENSG00000076248.10

Phylogenomic databases

HOGENOMiCLU_032162_2_1_1
OrthoDBi832568at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7374, 9 hits in 849 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UNG, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7374

Gene expression databases

BgeeiENSG00000076248, Expressed in secondary oocyte and 241 other tissues

Family and domain databases

CDDicd10027, UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148, UDG, 1 hit
InterProiView protein in InterPro
IPR002043, UDG_fam1
IPR018085, Ura-DNA_Glyclase_AS
IPR005122, Uracil-DNA_glycosylase-like
IPR036895, Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264, PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167, UDG, 1 hit
SMARTiView protein in SMART
SM00986, UDG, 1 hit
SUPFAMiSSF52141, SSF52141, 1 hit
TIGRFAMsiTIGR00628, ung, 1 hit
PROSITEiView protein in PROSITE
PS00130, U_DNA_GLYCOSYLASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5KTA5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5KTA5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: December 2, 2020
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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