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Entry version 82 (29 Sep 2021)
Sequence version 1 (08 Feb 2011)
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Protein
Submitted name:

Mitochondrial twinkle protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Mitochondrial twinkle proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000107815

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107815, Expressed in testis and 173 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E5KSY5, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E5KSY5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini384 – 635SF4 helicaseInterPro annotationAdd BLAST252

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni637 – 684DisorderedSequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi655 – 678Polar residuesSequence analysisAdd BLAST24

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012336_1_0_1

Identification of Orthologs from Complete Genome Data

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OMAi
YRKEALP

Database of Orthologous Groups

More...
OrthoDBi
212176at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E5KSY5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01029, TOPRIM_primases, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007694, DNA_helicase_DnaB-like_C
IPR027417, P-loop_NTPase
IPR034154, TOPRIM_DnaG/twinkle

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51199, SF4_HELICASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E5KSY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWVLLRSGYP LRILLPLRGE WMGRRGLPRN LAPGPPRRRY RKETLQALDM
60 70 80 90 100
PVLPVTATEI RQYLRGHGIP FQDGHSCLRA LSPFAESSQL KGQTGVTTSF
110 120 130 140 150
SLFIDKTTGH FLCMTSLAEG SWEDFQASVE GRGDGAREGF LLSKAPEFED
160 170 180 190 200
SEEVRRIWNR AIPLWELPDQ EEVQLADTMF GLTKVTDDTL KRFSVRYLRP
210 220 230 240 250
ARSLVFPWFS PGGSGLRGLK LLEAKCQGDG VSYEETTIPR PSAYHNLFGL
260 270 280 290 300
PLISRRDAEV VLTSRELDSL ALNQSTGLPT LTLPRGTTCL PPALLPYLEQ
310 320 330 340 350
FRRIVFWLGD DLRSWEAAKL FARKLNPKRC FLVRPGDQQP RPLEALNGGF
360 370 380 390 400
NLSRILRTAL PAWHKSIVSF RQLREEVLGE LSNVEQAAGL RWSRFPDLNR
410 420 430 440 450
ILKGHRKGEL TVFTGPTGSG KTTFISEYAL DLCSQGVNTL WGSFEISNVR
460 470 480 490 500
LARVMLTQFA EGRLEDQLDK YDHWADRFED LPLYFMTFHG QQSIRTVIDT
510 520 530 540 550
MQHAVYVYDI CHVIIDNLQF MMGHEQLSTD RIAAQDYIIG VFRKFATDNN
560 570 580 590 600
CHVTLVIHPR KEDDDKELQT ASIFGSAKAS QEADNVLILQ DRKLVTGPGK
610 620 630 640 650
RYLQVSKNRF DGDVGVFPLE FNKNSLTFSI PPKNKARLKK IKDDTGPVAK
660 670 680
KPSSGKKGAT TQNSEICSGQ APTPDQPDTS KRSK
Length:684
Mass (Da):77,154
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58186043888234DA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HQ206106 Genomic DNA Translation: ADP92014.1
HQ206107 Genomic DNA Translation: ADP92015.1
HQ206108 Genomic DNA Translation: ADP92016.1
HQ206109 Genomic DNA Translation: ADP92017.1
HQ206110 Genomic DNA Translation: ADP92018.1
HQ206111 Genomic DNA Translation: ADP92019.1
HQ206112 Genomic DNA Translation: ADP92020.1
HQ206113 Genomic DNA Translation: ADP92021.1
HQ206114 Genomic DNA Translation: ADP92022.1
HQ206115 Genomic DNA Translation: ADP92023.1
HQ206116 Genomic DNA Translation: ADP92024.1
HQ206117 Genomic DNA Translation: ADP92025.1
HQ206118 Genomic DNA Translation: ADP92026.1
HQ206119 Genomic DNA Translation: ADP92027.1
HQ206120 Genomic DNA Translation: ADP92028.1
HQ206121 Genomic DNA Translation: ADP92029.1
HQ206122 Genomic DNA Translation: ADP92030.1
HQ206123 Genomic DNA Translation: ADP92031.1
HQ206124 Genomic DNA Translation: ADP92032.1
HQ206125 Genomic DNA Translation: ADP92033.1
HQ206126 Genomic DNA Translation: ADP92034.1
HQ206127 Genomic DNA Translation: ADP92035.1
HQ206128 Genomic DNA Translation: ADP92036.1
HQ206129 Genomic DNA Translation: ADP92037.1
HQ206130 Genomic DNA Translation: ADP92038.1
HQ206131 Genomic DNA Translation: ADP92039.1
HQ206132 Genomic DNA Translation: ADP92040.1
HQ206133 Genomic DNA Translation: ADP92041.1
HQ206134 Genomic DNA Translation: ADP92042.1
HQ206135 Genomic DNA Translation: ADP92043.1
HQ206136 Genomic DNA Translation: ADP92044.1
HQ206137 Genomic DNA Translation: ADP92045.1
HQ206138 Genomic DNA Translation: ADP92046.1
HQ206139 Genomic DNA Translation: ADP92047.1
HQ206140 Genomic DNA Translation: ADP92048.1
HQ206141 Genomic DNA Translation: ADP92049.1
HQ206142 Genomic DNA Translation: ADP92050.1
HQ206143 Genomic DNA Translation: ADP92051.1
HQ206144 Genomic DNA Translation: ADP92052.1
HQ206145 Genomic DNA Translation: ADP92053.1

NCBI Reference Sequences

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RefSeqi
NP_068602.2, NM_021830.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
56652

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56652

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ206106 Genomic DNA Translation: ADP92014.1
HQ206107 Genomic DNA Translation: ADP92015.1
HQ206108 Genomic DNA Translation: ADP92016.1
HQ206109 Genomic DNA Translation: ADP92017.1
HQ206110 Genomic DNA Translation: ADP92018.1
HQ206111 Genomic DNA Translation: ADP92019.1
HQ206112 Genomic DNA Translation: ADP92020.1
HQ206113 Genomic DNA Translation: ADP92021.1
HQ206114 Genomic DNA Translation: ADP92022.1
HQ206115 Genomic DNA Translation: ADP92023.1
HQ206116 Genomic DNA Translation: ADP92024.1
HQ206117 Genomic DNA Translation: ADP92025.1
HQ206118 Genomic DNA Translation: ADP92026.1
HQ206119 Genomic DNA Translation: ADP92027.1
HQ206120 Genomic DNA Translation: ADP92028.1
HQ206121 Genomic DNA Translation: ADP92029.1
HQ206122 Genomic DNA Translation: ADP92030.1
HQ206123 Genomic DNA Translation: ADP92031.1
HQ206124 Genomic DNA Translation: ADP92032.1
HQ206125 Genomic DNA Translation: ADP92033.1
HQ206126 Genomic DNA Translation: ADP92034.1
HQ206127 Genomic DNA Translation: ADP92035.1
HQ206128 Genomic DNA Translation: ADP92036.1
HQ206129 Genomic DNA Translation: ADP92037.1
HQ206130 Genomic DNA Translation: ADP92038.1
HQ206131 Genomic DNA Translation: ADP92039.1
HQ206132 Genomic DNA Translation: ADP92040.1
HQ206133 Genomic DNA Translation: ADP92041.1
HQ206134 Genomic DNA Translation: ADP92042.1
HQ206135 Genomic DNA Translation: ADP92043.1
HQ206136 Genomic DNA Translation: ADP92044.1
HQ206137 Genomic DNA Translation: ADP92045.1
HQ206138 Genomic DNA Translation: ADP92046.1
HQ206139 Genomic DNA Translation: ADP92047.1
HQ206140 Genomic DNA Translation: ADP92048.1
HQ206141 Genomic DNA Translation: ADP92049.1
HQ206142 Genomic DNA Translation: ADP92050.1
HQ206143 Genomic DNA Translation: ADP92051.1
HQ206144 Genomic DNA Translation: ADP92052.1
HQ206145 Genomic DNA Translation: ADP92053.1
RefSeqiNP_068602.2, NM_021830.4

3D structure databases

SMRiE5KSY5
ModBaseiSearch...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1261, 224 antibodies

The DNASU plasmid repository

More...
DNASUi
56652

Genome annotation databases

GeneIDi56652
KEGGihsa:56652

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56652
VEuPathDBiHostDB:ENSG00000107815

Phylogenomic databases

HOGENOMiCLU_012336_1_0_1
OMAiYRKEALP
OrthoDBi212176at2759
PhylomeDBiE5KSY5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
56652, 323 hits in 1013 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56652

Gene expression databases

BgeeiENSG00000107815, Expressed in testis and 173 other tissues
ExpressionAtlasiE5KSY5, baseline and differential

Family and domain databases

CDDicd01029, TOPRIM_primases, 1 hit
Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR007694, DNA_helicase_DnaB-like_C
IPR027417, P-loop_NTPase
IPR034154, TOPRIM_DnaG/twinkle
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51199, SF4_HELICASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5KSY5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5KSY5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 29, 2021
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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