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Entry version 89 (29 Sep 2021)
Sequence version 1 (08 Feb 2011)
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Protein

Spastin

Gene

SPAST

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.UniRule annotation EC:5.6.1.1

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi382 – 389ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAllosteric enzymeUniRule annotation, Developmental proteinUniRule annotation, IsomeraseUniRule annotationARBA annotation
Biological processCell cycle, Cell divisionUniRule annotationARBA annotation, DifferentiationUniRule annotation, NeurogenesisUniRule annotation
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SpastinUniRule annotation (EC:5.6.1.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPASTUniRule annotationImported
Synonyms:SPG4UniRule annotation
ORF Names:hCG_23080Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000021574

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 56CytoplasmicUniRule annotationAdd BLAST56
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei57 – 78HelicalSequence analysisAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei57 – 77HelicalUniRule annotationAdd BLAST21
Topological domaini78 – 616CytoplasmicUniRule annotationAdd BLAST539

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotationARBA annotation, Endoplasmic reticulumUniRule annotation, Membrane, MicrotubuleUniRule annotationARBA annotation, NucleusUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E5KRP5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000021574, Expressed in cerebral cortex and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E5KRP5, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers.

Interacts (via MIT domain) with CHMP1B; the interaction is direct.

Interacts with SSNA1.

Interacts with ATL1.

Interacts with RTN1.

Interacts with ZFYVE27.

Interacts with REEP1.

Interacts (via MIT domain) with IST1.

UniRule annotation

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E5KRP5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini116 – 194MITInterPro annotationAdd BLAST79
Domaini374 – 510AAAInterPro annotationAdd BLAST137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 43DisorderedSequence analysisAdd BLAST43
Regioni224 – 266DisorderedSequence analysisAdd BLAST43
Regioni278 – 312DisorderedSequence analysisAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi4 – 11Nuclear localization signalUniRule annotation8
Motifi59 – 67Nuclear export signalUniRule annotation9
Motifi309 – 312Nuclear localization signalUniRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 43Pro residuesSequence analysisAdd BLAST26
Compositional biasi238 – 256Polar residuesSequence analysisAdd BLAST19
Compositional biasi278 – 305Polar residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAA ATPase family. Spastin subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMTNEPM

Database of Orthologous Groups

More...
OrthoDBi
1176820at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E5KRP5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03021, Spastin, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR041569, AAA_lid_3
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR007330, MIT_dom
IPR027417, P-loop_NTPase
IPR017179, Spastin
IPR035106, Spastin_chordate
IPR015415, Vps4_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004, AAA, 1 hit
PF17862, AAA_lid_3, 1 hit
PF09336, Vps4_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037338, Spastin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit
SM00745, MIT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00674, AAA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E5KRP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSPGGRGKK KGSGGASNPV PPRPPPPCLA PAPPAAGPAP PPESPHKRNL
60 70 80 90 100
YYFSYPLFVG FALLRLVAFH LGLLFVWLCQ RFSRALMAAK RSSGAAPAPA
110 120 130 140 150
SASAPAPVPG GEAERVRVFH KQAFEYISIA LRIDEDEKAG QKEQAVEWYK
160 170 180 190 200
KGIEELEKGI AVIVTGQGEQ CERARRLQAK MMTNLVMAKD RLQLLEKMQP
210 220 230 240 250
VLPFSKSQTD VYNDSTNLAC RNGHLQSESG AVPKRKDPLT HTSNSLPRSK
260 270 280 290 300
TVMKTGSAGL SGHHRAPSYS GLSMVSGVKQ GSGPAPTTHK GTPKTNRTNK
310 320 330 340 350
PSTPTTATRK KKDLKNFRNV DSNLANLIMN EIVDNGTAVK FDDIAGQDLA
360 370 380 390 400
KQALQEIVIL PSLRPELFTG LRAPARGLLL FGPPGNGKTM LAKAVAAESN
410 420 430 440 450
ATFFNISAAS LTSKYVGEGE KLVRALFAVA RELQPSIIFI DEVDSLLCER
460 470 480 490 500
REGEHDASRR LKTEFLIEFD GVQSAGDDRV LVMGATNRPQ ELDEAVLRRF
510 520 530 540 550
IKRVYVSLPN EETRLLLLKN LLCKQGSPLT QKELAQLARM TDGYSGSDLT
560 570 580 590 600
ALAKDAALGP IRELKPEQVK NMSASEMRNI RLSDFTESLK KIKRSVSPQT
610
LEAYIRWNKD FGDTTV
Length:616
Mass (Da):67,197
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75E5FC5787132B4C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HQ205746 Genomic DNA Translation: ADP91574.1
HQ205747 Genomic DNA Translation: ADP91576.1
HQ205748 Genomic DNA Translation: ADP91578.1
HQ205749 Genomic DNA Translation: ADP91580.1
HQ205750 Genomic DNA Translation: ADP91582.1
HQ205751 Genomic DNA Translation: ADP91584.1
HQ205752 Genomic DNA Translation: ADP91586.1
HQ205753 Genomic DNA Translation: ADP91588.1
HQ205754 Genomic DNA Translation: ADP91590.1
HQ205755 Genomic DNA Translation: ADP91592.1
HQ205756 Genomic DNA Translation: ADP91594.1
HQ205757 Genomic DNA Translation: ADP91596.1
HQ205758 Genomic DNA Translation: ADP91598.1
HQ205759 Genomic DNA Translation: ADP91600.1
HQ205760 Genomic DNA Translation: ADP91602.1
HQ205761 Genomic DNA Translation: ADP91604.1
HQ205762 Genomic DNA Translation: ADP91606.1
HQ205763 Genomic DNA Translation: ADP91608.1
HQ205764 Genomic DNA Translation: ADP91610.1
HQ205765 Genomic DNA Translation: ADP91612.1
HQ205766 Genomic DNA Translation: ADP91614.1
HQ205767 Genomic DNA Translation: ADP91616.1
HQ205768 Genomic DNA Translation: ADP91618.1
HQ205769 Genomic DNA Translation: ADP91620.1
HQ205770 Genomic DNA Translation: ADP91622.1
HQ205771 Genomic DNA Translation: ADP91624.1
HQ205772 Genomic DNA Translation: ADP91626.1
HQ205773 Genomic DNA Translation: ADP91628.1
HQ205774 Genomic DNA Translation: ADP91630.1
HQ205775 Genomic DNA Translation: ADP91632.1
HQ205776 Genomic DNA Translation: ADP91634.1
HQ205777 Genomic DNA Translation: ADP91636.1
HQ205778 Genomic DNA Translation: ADP91638.1
HQ205779 Genomic DNA Translation: ADP91640.1
HQ205780 Genomic DNA Translation: ADP91642.1
HQ205781 Genomic DNA Translation: ADP91644.1
HQ205782 Genomic DNA Translation: ADP91646.1
HQ205783 Genomic DNA Translation: ADP91648.1
HQ205784 Genomic DNA Translation: ADP91650.1
HQ205785 Genomic DNA Translation: ADP91652.1
CH471053 Genomic DNA Translation: EAX00461.1

NCBI Reference Sequences

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RefSeqi
NP_055761.2, NM_014946.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6683

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6683

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205746 Genomic DNA Translation: ADP91574.1
HQ205747 Genomic DNA Translation: ADP91576.1
HQ205748 Genomic DNA Translation: ADP91578.1
HQ205749 Genomic DNA Translation: ADP91580.1
HQ205750 Genomic DNA Translation: ADP91582.1
HQ205751 Genomic DNA Translation: ADP91584.1
HQ205752 Genomic DNA Translation: ADP91586.1
HQ205753 Genomic DNA Translation: ADP91588.1
HQ205754 Genomic DNA Translation: ADP91590.1
HQ205755 Genomic DNA Translation: ADP91592.1
HQ205756 Genomic DNA Translation: ADP91594.1
HQ205757 Genomic DNA Translation: ADP91596.1
HQ205758 Genomic DNA Translation: ADP91598.1
HQ205759 Genomic DNA Translation: ADP91600.1
HQ205760 Genomic DNA Translation: ADP91602.1
HQ205761 Genomic DNA Translation: ADP91604.1
HQ205762 Genomic DNA Translation: ADP91606.1
HQ205763 Genomic DNA Translation: ADP91608.1
HQ205764 Genomic DNA Translation: ADP91610.1
HQ205765 Genomic DNA Translation: ADP91612.1
HQ205766 Genomic DNA Translation: ADP91614.1
HQ205767 Genomic DNA Translation: ADP91616.1
HQ205768 Genomic DNA Translation: ADP91618.1
HQ205769 Genomic DNA Translation: ADP91620.1
HQ205770 Genomic DNA Translation: ADP91622.1
HQ205771 Genomic DNA Translation: ADP91624.1
HQ205772 Genomic DNA Translation: ADP91626.1
HQ205773 Genomic DNA Translation: ADP91628.1
HQ205774 Genomic DNA Translation: ADP91630.1
HQ205775 Genomic DNA Translation: ADP91632.1
HQ205776 Genomic DNA Translation: ADP91634.1
HQ205777 Genomic DNA Translation: ADP91636.1
HQ205778 Genomic DNA Translation: ADP91638.1
HQ205779 Genomic DNA Translation: ADP91640.1
HQ205780 Genomic DNA Translation: ADP91642.1
HQ205781 Genomic DNA Translation: ADP91644.1
HQ205782 Genomic DNA Translation: ADP91646.1
HQ205783 Genomic DNA Translation: ADP91648.1
HQ205784 Genomic DNA Translation: ADP91650.1
HQ205785 Genomic DNA Translation: ADP91652.1
CH471053 Genomic DNA Translation: EAX00461.1
RefSeqiNP_055761.2, NM_014946.3

3D structure databases

SMRiE5KRP5
ModBaseiSearch...

Proteomic databases

PRIDEiE5KRP5

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2246, 251 antibodies

The DNASU plasmid repository

More...
DNASUi
6683

Genome annotation databases

GeneIDi6683
KEGGihsa:6683

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6683
VEuPathDBiHostDB:ENSG00000021574

Phylogenomic databases

OMAiGMTNEPM
OrthoDBi1176820at2759
PhylomeDBiE5KRP5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
6683, 15 hits in 1018 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPAST, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6683

Gene expression databases

BgeeiENSG00000021574, Expressed in cerebral cortex and 236 other tissues
ExpressionAtlasiE5KRP5, baseline and differential

Family and domain databases

Gene3Di3.40.50.300, 1 hit
HAMAPiMF_03021, Spastin, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR041569, AAA_lid_3
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR007330, MIT_dom
IPR027417, P-loop_NTPase
IPR017179, Spastin
IPR035106, Spastin_chordate
IPR015415, Vps4_C
PfamiView protein in Pfam
PF00004, AAA, 1 hit
PF17862, AAA_lid_3, 1 hit
PF09336, Vps4_C, 1 hit
PIRSFiPIRSF037338, Spastin, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00745, MIT, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674, AAA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5KRP5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5KRP5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 29, 2021
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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