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UniProtKB - E5KRK5 (E5KRK5_HUMAN)

Entry version 81 (02 Dec 2020)
Sequence version 1 (08 Feb 2011)
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Protein

Complex I-75kD

Gene

NDUFS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseARBA annotation
Ligand4Fe-4SARBA annotation, Iron, Iron-sulfur, Metal-binding, UbiquinoneImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complex I-75kDARBA annotation (EC:7.1.1.2ARBA annotation)
Alternative name(s):
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDUFS1Imported
ORF Names:hCG_17250Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000023228.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000023228, Expressed in heart and 254 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Complex I is composed of 45 different subunits.

ARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E5KRK5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 1082Fe-2S ferredoxin-typeInterPro annotationAdd BLAST79
Domaini108 – 1474Fe-4S His(Cys)3-ligated-typeInterPro annotationAdd BLAST40
Domaini245 – 3014Fe-4S Mo/W bis-MGD-typeInterPro annotationAdd BLAST57

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I 75 kDa subunit family.UniRule annotationARBA annotation

Keywords - Domaini

Transit peptideARBA annotation

Family and domain databases

Conserved Domains Database

More...CDDi		cd00207, fer2, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036010, 2Fe-2S_ferredoxin-like_sf
IPR001041, 2Fe-2S_ferredoxin-type
IPR006656, Mopterin_OxRdtase
IPR006963, Mopterin_OxRdtase_4Fe-4S_dom
IPR000283, NADH_UbQ_OxRdtase_75kDa_su_CS
IPR010228, NADH_UbQ_OxRdtase_Gsu
IPR019574, NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
IPR015405, NuoG_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00384, Molybdopterin, 1 hit
PF10588, NADH-G_4Fe-4S_3, 1 hit
PF09326, NADH_dhqG_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00929, NADH-G_4Fe-4S_3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54292, SSF54292, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01973, NuoG, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51085, 2FE2S_FER_2, 1 hit
PS51839, 4FE4S_HC3, 1 hit
PS51669, 4FE4S_MOW_BIS_MGD, 1 hit
PS00641, COMPLEX1_75K_1, 1 hit
PS00642, COMPLEX1_75K_2, 1 hit
PS00643, COMPLEX1_75K_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E5KRK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRIPVRKAL VGLSKSPKGC VRTTATAASN LIEVFVDGQS VMVEPGTTVL 
        60         70         80         90        100
QACEKVGMQI PRFCYHERLS VAGNCRMCLV EIEKAPKVVA ACAMPVMKGW 
       110        120        130        140        150
NILTNSEKSK KAREGVMEFL LANHPLDCPI CDQGGECDLQ DQSMMFGNDR 
       160        170        180        190        200
SRFLEGKRAV EDKNIGPLVK TIMTRCIQCT RCIRFASEIA GVDDLGTTGR 
       210        220        230        240        250
GNDMQVGTYI EKMFMSELSG NIIDICPVGA LTSKPYAFTA RPWETRKTES 
       260        270        280        290        300
IDVMDAVGSN IVVSTRTGEV MRILPRMHED INEEWISDKT RFAYDGLKRQ 
       310        320        330        340        350
RLTEPMVRNE KGLLTYTSWE DALSRVAGML QSFQGKDVAA IAGGLVDAEA 
       360        370        380        390        400
LVALKDLLNR VDSDTLCTEE VFPTAGAGTD LRSNYLLNTT IAGVEEADVV 
       410        420        430        440        450
LLVGTNPRFE APLFNARIRK SWLHNDLKVA LIGSPVDLTY TYDHLGDSPK 
       460        470        480        490        500
ILQDIASGSH PFSQVLKEAK KPMVVLGSSA LQRNDGAAIL AAVSSIAQKI 
       510        520        530        540        550
RMTSGVTGDW KVMNILHRIA SQVAALDLGY KPGVEAIRKN PPKVLFLLGA 
       560        570        580        590        600
DGGCITRQDL PKDCFIIYQG HHGDVGAPIA DVILPGAAYT EKSATYVNTE 
       610        620        630        640        650
GRAQQTKVAV TPPGLAREDW KIIRALSEIA GMTLPYDTLD QVRNRLEEVS 
       660        670        680        690        700
PNLVRYDDIE GANYFQQANE LSKLVNQQLL ADPLVPPQLT IKDFYMTDSI 
       710        720 
SRASQTMAKC VKAVTEGAQA VEEPSIC
Length:727
Mass (Da):79,468
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C35F4B8294771FB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
HQ205706 Genomic DNA Translation: ADP91534.1
HQ205707 Genomic DNA Translation: ADP91535.1
HQ205708 Genomic DNA Translation: ADP91536.1
HQ205709 Genomic DNA Translation: ADP91537.1
HQ205710 Genomic DNA Translation: ADP91538.1
HQ205711 Genomic DNA Translation: ADP91539.1
HQ205712 Genomic DNA Translation: ADP91540.1
HQ205713 Genomic DNA Translation: ADP91541.1
HQ205714 Genomic DNA Translation: ADP91542.1
HQ205715 Genomic DNA Translation: ADP91543.1
HQ205716 Genomic DNA Translation: ADP91544.1
HQ205717 Genomic DNA Translation: ADP91545.1
HQ205718 Genomic DNA Translation: ADP91546.1
HQ205719 Genomic DNA Translation: ADP91547.1
HQ205720 Genomic DNA Translation: ADP91548.1
HQ205721 Genomic DNA Translation: ADP91549.1
HQ205722 Genomic DNA Translation: ADP91550.1
HQ205723 Genomic DNA Translation: ADP91551.1
HQ205724 Genomic DNA Translation: ADP91552.1
HQ205725 Genomic DNA Translation: ADP91553.1
HQ205726 Genomic DNA Translation: ADP91554.1
HQ205727 Genomic DNA Translation: ADP91555.1
HQ205728 Genomic DNA Translation: ADP91556.1
HQ205729 Genomic DNA Translation: ADP91557.1
HQ205730 Genomic DNA Translation: ADP91558.1
HQ205731 Genomic DNA Translation: ADP91559.1
HQ205732 Genomic DNA Translation: ADP91560.1
HQ205733 Genomic DNA Translation: ADP91561.1
HQ205734 Genomic DNA Translation: ADP91562.1
HQ205735 Genomic DNA Translation: ADP91563.1
HQ205736 Genomic DNA Translation: ADP91564.1
HQ205737 Genomic DNA Translation: ADP91565.1
HQ205738 Genomic DNA Translation: ADP91566.1
HQ205739 Genomic DNA Translation: ADP91567.1
HQ205740 Genomic DNA Translation: ADP91568.1
HQ205741 Genomic DNA Translation: ADP91569.1
HQ205742 Genomic DNA Translation: ADP91570.1
HQ205743 Genomic DNA Translation: ADP91571.1
HQ205744 Genomic DNA Translation: ADP91572.1
HQ205745 Genomic DNA Translation: ADP91573.1
CH471063 Genomic DNA Translation: EAW70380.1

NCBI Reference Sequences

More...RefSeqi		NP_004997.4, NM_005006.6

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4719

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4719

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205706 Genomic DNA Translation: ADP91534.1
HQ205707 Genomic DNA Translation: ADP91535.1
HQ205708 Genomic DNA Translation: ADP91536.1
HQ205709 Genomic DNA Translation: ADP91537.1
HQ205710 Genomic DNA Translation: ADP91538.1
HQ205711 Genomic DNA Translation: ADP91539.1
HQ205712 Genomic DNA Translation: ADP91540.1
HQ205713 Genomic DNA Translation: ADP91541.1
HQ205714 Genomic DNA Translation: ADP91542.1
HQ205715 Genomic DNA Translation: ADP91543.1
HQ205716 Genomic DNA Translation: ADP91544.1
HQ205717 Genomic DNA Translation: ADP91545.1
HQ205718 Genomic DNA Translation: ADP91546.1
HQ205719 Genomic DNA Translation: ADP91547.1
HQ205720 Genomic DNA Translation: ADP91548.1
HQ205721 Genomic DNA Translation: ADP91549.1
HQ205722 Genomic DNA Translation: ADP91550.1
HQ205723 Genomic DNA Translation: ADP91551.1
HQ205724 Genomic DNA Translation: ADP91552.1
HQ205725 Genomic DNA Translation: ADP91553.1
HQ205726 Genomic DNA Translation: ADP91554.1
HQ205727 Genomic DNA Translation: ADP91555.1
HQ205728 Genomic DNA Translation: ADP91556.1
HQ205729 Genomic DNA Translation: ADP91557.1
HQ205730 Genomic DNA Translation: ADP91558.1
HQ205731 Genomic DNA Translation: ADP91559.1
HQ205732 Genomic DNA Translation: ADP91560.1
HQ205733 Genomic DNA Translation: ADP91561.1
HQ205734 Genomic DNA Translation: ADP91562.1
HQ205735 Genomic DNA Translation: ADP91563.1
HQ205736 Genomic DNA Translation: ADP91564.1
HQ205737 Genomic DNA Translation: ADP91565.1
HQ205738 Genomic DNA Translation: ADP91566.1
HQ205739 Genomic DNA Translation: ADP91567.1
HQ205740 Genomic DNA Translation: ADP91568.1
HQ205741 Genomic DNA Translation: ADP91569.1
HQ205742 Genomic DNA Translation: ADP91570.1
HQ205743 Genomic DNA Translation: ADP91571.1
HQ205744 Genomic DNA Translation: ADP91572.1
HQ205745 Genomic DNA Translation: ADP91573.1
CH471063 Genomic DNA Translation: EAW70380.1
RefSeqiNP_004997.4, NM_005006.6

3D structure databases

SMRiE5KRK5
ModBaseiSearch...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34175, 291 antibodies

Genome annotation databases

GeneIDi4719
KEGGihsa:4719

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4719
EuPathDBiHostDB:ENSG00000023228.13

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4719, 244 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NDUFS1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4719

Gene expression databases

BgeeiENSG00000023228, Expressed in heart and 254 other tissues

Family and domain databases

CDDicd00207, fer2, 1 hit
InterProiView protein in InterPro
IPR036010, 2Fe-2S_ferredoxin-like_sf
IPR001041, 2Fe-2S_ferredoxin-type
IPR006656, Mopterin_OxRdtase
IPR006963, Mopterin_OxRdtase_4Fe-4S_dom
IPR000283, NADH_UbQ_OxRdtase_75kDa_su_CS
IPR010228, NADH_UbQ_OxRdtase_Gsu
IPR019574, NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
IPR015405, NuoG_C
PfamiView protein in Pfam
PF00384, Molybdopterin, 1 hit
PF10588, NADH-G_4Fe-4S_3, 1 hit
PF09326, NADH_dhqG_C, 1 hit
SMARTiView protein in SMART
SM00929, NADH-G_4Fe-4S_3, 1 hit
SUPFAMiSSF54292, SSF54292, 1 hit
TIGRFAMsiTIGR01973, NuoG, 1 hit
PROSITEiView protein in PROSITE
PS51085, 2FE2S_FER_2, 1 hit
PS51839, 4FE4S_HC3, 1 hit
PS51669, 4FE4S_MOW_BIS_MGD, 1 hit
PS00641, COMPLEX1_75K_1, 1 hit
PS00642, COMPLEX1_75K_2, 1 hit
PS00643, COMPLEX1_75K_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5KRK5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5KRK5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: December 2, 2020
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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