UniProtKB - E5KRK5 (E5KRK5_HUMAN)
Protein
Complex I-75kD
Gene
NDUFS1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:7.1.1.2ARBA annotation
Cofactori
Protein has several cofactor binding sites:- [2Fe-2S] clusterARBA annotation
- [4Fe-4S] clusterARBA annotation
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- electron transfer activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
GO - Biological processi
- ATP synthesis coupled electron transport Source: InterPro
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Ligand | 4Fe-4SARBA annotation, Iron, Iron-sulfur, Metal-binding, UbiquinoneImported |
Names & Taxonomyi
Protein namesi | Recommended name: Complex I-75kDARBA annotation (EC:7.1.1.2ARBA annotation)Alternative name(s): NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialARBA annotation |
Gene namesi | Name:NDUFS1Imported ORF Names:hCG_17250Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000023228.13 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane ARBA annotation
Other locations
- Membrane ARBA annotation
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: HPA
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membraneARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000023228, Expressed in heart and 254 other tissues |
Interactioni
Subunit structurei
Complex I is composed of 45 different subunits.
ARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 108 | 2Fe-2S ferredoxin-typeInterPro annotationAdd BLAST | 79 | |
Domaini | 108 – 147 | 4Fe-4S His(Cys)3-ligated-typeInterPro annotationAdd BLAST | 40 | |
Domaini | 245 – 301 | 4Fe-4S Mo/W bis-MGD-typeInterPro annotationAdd BLAST | 57 |
Sequence similaritiesi
Keywords - Domaini
Transit peptideARBA annotationFamily and domain databases
CDDi | cd00207, fer2, 1 hit |
InterProi | View protein in InterPro IPR036010, 2Fe-2S_ferredoxin-like_sf IPR001041, 2Fe-2S_ferredoxin-type IPR006656, Mopterin_OxRdtase IPR006963, Mopterin_OxRdtase_4Fe-4S_dom IPR000283, NADH_UbQ_OxRdtase_75kDa_su_CS IPR010228, NADH_UbQ_OxRdtase_Gsu IPR019574, NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd IPR015405, NuoG_C |
Pfami | View protein in Pfam PF00384, Molybdopterin, 1 hit PF10588, NADH-G_4Fe-4S_3, 1 hit PF09326, NADH_dhqG_C, 1 hit |
SMARTi | View protein in SMART SM00929, NADH-G_4Fe-4S_3, 1 hit |
SUPFAMi | SSF54292, SSF54292, 1 hit |
TIGRFAMsi | TIGR01973, NuoG, 1 hit |
PROSITEi | View protein in PROSITE PS51085, 2FE2S_FER_2, 1 hit PS51839, 4FE4S_HC3, 1 hit PS51669, 4FE4S_MOW_BIS_MGD, 1 hit PS00641, COMPLEX1_75K_1, 1 hit PS00642, COMPLEX1_75K_2, 1 hit PS00643, COMPLEX1_75K_3, 1 hit |
i Sequence
Sequence statusi: Complete.
E5KRK5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRIPVRKAL VGLSKSPKGC VRTTATAASN LIEVFVDGQS VMVEPGTTVL
60 70 80 90 100
QACEKVGMQI PRFCYHERLS VAGNCRMCLV EIEKAPKVVA ACAMPVMKGW
110 120 130 140 150
NILTNSEKSK KAREGVMEFL LANHPLDCPI CDQGGECDLQ DQSMMFGNDR
160 170 180 190 200
SRFLEGKRAV EDKNIGPLVK TIMTRCIQCT RCIRFASEIA GVDDLGTTGR
210 220 230 240 250
GNDMQVGTYI EKMFMSELSG NIIDICPVGA LTSKPYAFTA RPWETRKTES
260 270 280 290 300
IDVMDAVGSN IVVSTRTGEV MRILPRMHED INEEWISDKT RFAYDGLKRQ
310 320 330 340 350
RLTEPMVRNE KGLLTYTSWE DALSRVAGML QSFQGKDVAA IAGGLVDAEA
360 370 380 390 400
LVALKDLLNR VDSDTLCTEE VFPTAGAGTD LRSNYLLNTT IAGVEEADVV
410 420 430 440 450
LLVGTNPRFE APLFNARIRK SWLHNDLKVA LIGSPVDLTY TYDHLGDSPK
460 470 480 490 500
ILQDIASGSH PFSQVLKEAK KPMVVLGSSA LQRNDGAAIL AAVSSIAQKI
510 520 530 540 550
RMTSGVTGDW KVMNILHRIA SQVAALDLGY KPGVEAIRKN PPKVLFLLGA
560 570 580 590 600
DGGCITRQDL PKDCFIIYQG HHGDVGAPIA DVILPGAAYT EKSATYVNTE
610 620 630 640 650
GRAQQTKVAV TPPGLAREDW KIIRALSEIA GMTLPYDTLD QVRNRLEEVS
660 670 680 690 700
PNLVRYDDIE GANYFQQANE LSKLVNQQLL ADPLVPPQLT IKDFYMTDSI
710 720
SRASQTMAKC VKAVTEGAQA VEEPSIC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ205706 Genomic DNA Translation: ADP91534.1 HQ205707 Genomic DNA Translation: ADP91535.1 HQ205708 Genomic DNA Translation: ADP91536.1 HQ205709 Genomic DNA Translation: ADP91537.1 HQ205710 Genomic DNA Translation: ADP91538.1 HQ205711 Genomic DNA Translation: ADP91539.1 HQ205712 Genomic DNA Translation: ADP91540.1 HQ205713 Genomic DNA Translation: ADP91541.1 HQ205714 Genomic DNA Translation: ADP91542.1 HQ205715 Genomic DNA Translation: ADP91543.1 HQ205716 Genomic DNA Translation: ADP91544.1 HQ205717 Genomic DNA Translation: ADP91545.1 HQ205718 Genomic DNA Translation: ADP91546.1 HQ205719 Genomic DNA Translation: ADP91547.1 HQ205720 Genomic DNA Translation: ADP91548.1 HQ205721 Genomic DNA Translation: ADP91549.1 HQ205722 Genomic DNA Translation: ADP91550.1 HQ205723 Genomic DNA Translation: ADP91551.1 HQ205724 Genomic DNA Translation: ADP91552.1 HQ205725 Genomic DNA Translation: ADP91553.1 HQ205726 Genomic DNA Translation: ADP91554.1 HQ205727 Genomic DNA Translation: ADP91555.1 HQ205728 Genomic DNA Translation: ADP91556.1 HQ205729 Genomic DNA Translation: ADP91557.1 HQ205730 Genomic DNA Translation: ADP91558.1 HQ205731 Genomic DNA Translation: ADP91559.1 HQ205732 Genomic DNA Translation: ADP91560.1 HQ205733 Genomic DNA Translation: ADP91561.1 HQ205734 Genomic DNA Translation: ADP91562.1 HQ205735 Genomic DNA Translation: ADP91563.1 HQ205736 Genomic DNA Translation: ADP91564.1 HQ205737 Genomic DNA Translation: ADP91565.1 HQ205738 Genomic DNA Translation: ADP91566.1 HQ205739 Genomic DNA Translation: ADP91567.1 HQ205740 Genomic DNA Translation: ADP91568.1 HQ205741 Genomic DNA Translation: ADP91569.1 HQ205742 Genomic DNA Translation: ADP91570.1 HQ205743 Genomic DNA Translation: ADP91571.1 HQ205744 Genomic DNA Translation: ADP91572.1 HQ205745 Genomic DNA Translation: ADP91573.1 CH471063 Genomic DNA Translation: EAW70380.1 |
RefSeqi | NP_004997.4, NM_005006.6 |
Genome annotation databases
GeneIDi | 4719 |
KEGGi | hsa:4719 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ205706 Genomic DNA Translation: ADP91534.1 HQ205707 Genomic DNA Translation: ADP91535.1 HQ205708 Genomic DNA Translation: ADP91536.1 HQ205709 Genomic DNA Translation: ADP91537.1 HQ205710 Genomic DNA Translation: ADP91538.1 HQ205711 Genomic DNA Translation: ADP91539.1 HQ205712 Genomic DNA Translation: ADP91540.1 HQ205713 Genomic DNA Translation: ADP91541.1 HQ205714 Genomic DNA Translation: ADP91542.1 HQ205715 Genomic DNA Translation: ADP91543.1 HQ205716 Genomic DNA Translation: ADP91544.1 HQ205717 Genomic DNA Translation: ADP91545.1 HQ205718 Genomic DNA Translation: ADP91546.1 HQ205719 Genomic DNA Translation: ADP91547.1 HQ205720 Genomic DNA Translation: ADP91548.1 HQ205721 Genomic DNA Translation: ADP91549.1 HQ205722 Genomic DNA Translation: ADP91550.1 HQ205723 Genomic DNA Translation: ADP91551.1 HQ205724 Genomic DNA Translation: ADP91552.1 HQ205725 Genomic DNA Translation: ADP91553.1 HQ205726 Genomic DNA Translation: ADP91554.1 HQ205727 Genomic DNA Translation: ADP91555.1 HQ205728 Genomic DNA Translation: ADP91556.1 HQ205729 Genomic DNA Translation: ADP91557.1 HQ205730 Genomic DNA Translation: ADP91558.1 HQ205731 Genomic DNA Translation: ADP91559.1 HQ205732 Genomic DNA Translation: ADP91560.1 HQ205733 Genomic DNA Translation: ADP91561.1 HQ205734 Genomic DNA Translation: ADP91562.1 HQ205735 Genomic DNA Translation: ADP91563.1 HQ205736 Genomic DNA Translation: ADP91564.1 HQ205737 Genomic DNA Translation: ADP91565.1 HQ205738 Genomic DNA Translation: ADP91566.1 HQ205739 Genomic DNA Translation: ADP91567.1 HQ205740 Genomic DNA Translation: ADP91568.1 HQ205741 Genomic DNA Translation: ADP91569.1 HQ205742 Genomic DNA Translation: ADP91570.1 HQ205743 Genomic DNA Translation: ADP91571.1 HQ205744 Genomic DNA Translation: ADP91572.1 HQ205745 Genomic DNA Translation: ADP91573.1 CH471063 Genomic DNA Translation: EAW70380.1 |
RefSeqi | NP_004997.4, NM_005006.6 |
3D structure databases
SMRi | E5KRK5 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 34175, 291 antibodies |
Genome annotation databases
GeneIDi | 4719 |
KEGGi | hsa:4719 |
Organism-specific databases
CTDi | 4719 |
EuPathDBi | HostDB:ENSG00000023228.13 |
Miscellaneous databases
BioGRID-ORCSi | 4719, 244 hits in 845 CRISPR screens |
ChiTaRSi | NDUFS1, human |
GenomeRNAii | 4719 |
Gene expression databases
Bgeei | ENSG00000023228, Expressed in heart and 254 other tissues |
Family and domain databases
CDDi | cd00207, fer2, 1 hit |
InterProi | View protein in InterPro IPR036010, 2Fe-2S_ferredoxin-like_sf IPR001041, 2Fe-2S_ferredoxin-type IPR006656, Mopterin_OxRdtase IPR006963, Mopterin_OxRdtase_4Fe-4S_dom IPR000283, NADH_UbQ_OxRdtase_75kDa_su_CS IPR010228, NADH_UbQ_OxRdtase_Gsu IPR019574, NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd IPR015405, NuoG_C |
Pfami | View protein in Pfam PF00384, Molybdopterin, 1 hit PF10588, NADH-G_4Fe-4S_3, 1 hit PF09326, NADH_dhqG_C, 1 hit |
SMARTi | View protein in SMART SM00929, NADH-G_4Fe-4S_3, 1 hit |
SUPFAMi | SSF54292, SSF54292, 1 hit |
TIGRFAMsi | TIGR01973, NuoG, 1 hit |
PROSITEi | View protein in PROSITE PS51085, 2FE2S_FER_2, 1 hit PS51839, 4FE4S_HC3, 1 hit PS51669, 4FE4S_MOW_BIS_MGD, 1 hit PS00641, COMPLEX1_75K_1, 1 hit PS00642, COMPLEX1_75K_2, 1 hit PS00643, COMPLEX1_75K_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E5KRK5_HUMAN | |
Accessioni | E5KRK5Primary (citable) accession number: E5KRK5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |