Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 74 (16 Oct 2019)
Sequence version 1 (08 Feb 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit

Gene

NDUFS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandUbiquinoneImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunitImported
Submitted name:
NADH dehydrogenase (Ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase), isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDUFS1Imported
ORF Names:hCG_17250Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E5KRK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000023228 Expressed in 242 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E5KRK5 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E5KRK5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 1082Fe-2S ferredoxin-typeInterPro annotationAdd BLAST79
Domaini108 – 1474Fe-4S His(Cys)3-ligated-typeInterPro annotationAdd BLAST40
Domaini245 – 3014Fe-4S Mo/W bis-MGD-typeInterPro annotationAdd BLAST57

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I 75 kDa subunit family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2282 Eukaryota
COG1034 LUCA

KEGG Orthology (KO)

More...
KOi
K03934

Database of Orthologous Groups

More...
OrthoDBi
1095510at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00207 fer2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS
IPR010228 NADH_UbQ_OxRdtase_Gsu
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
IPR015405 NuoG_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00384 Molybdopterin, 1 hit
PF10588 NADH-G_4Fe-4S_3, 1 hit
PF09326 NADH_dhqG_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00929 NADH-G_4Fe-4S_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54292 SSF54292, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01973 NuoG, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS51839 4FE4S_HC3, 1 hit
PS51669 4FE4S_MOW_BIS_MGD, 1 hit
PS00641 COMPLEX1_75K_1, 1 hit
PS00642 COMPLEX1_75K_2, 1 hit
PS00643 COMPLEX1_75K_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E5KRK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRIPVRKAL VGLSKSPKGC VRTTATAASN LIEVFVDGQS VMVEPGTTVL
60 70 80 90 100
QACEKVGMQI PRFCYHERLS VAGNCRMCLV EIEKAPKVVA ACAMPVMKGW
110 120 130 140 150
NILTNSEKSK KAREGVMEFL LANHPLDCPI CDQGGECDLQ DQSMMFGNDR
160 170 180 190 200
SRFLEGKRAV EDKNIGPLVK TIMTRCIQCT RCIRFASEIA GVDDLGTTGR
210 220 230 240 250
GNDMQVGTYI EKMFMSELSG NIIDICPVGA LTSKPYAFTA RPWETRKTES
260 270 280 290 300
IDVMDAVGSN IVVSTRTGEV MRILPRMHED INEEWISDKT RFAYDGLKRQ
310 320 330 340 350
RLTEPMVRNE KGLLTYTSWE DALSRVAGML QSFQGKDVAA IAGGLVDAEA
360 370 380 390 400
LVALKDLLNR VDSDTLCTEE VFPTAGAGTD LRSNYLLNTT IAGVEEADVV
410 420 430 440 450
LLVGTNPRFE APLFNARIRK SWLHNDLKVA LIGSPVDLTY TYDHLGDSPK
460 470 480 490 500
ILQDIASGSH PFSQVLKEAK KPMVVLGSSA LQRNDGAAIL AAVSSIAQKI
510 520 530 540 550
RMTSGVTGDW KVMNILHRIA SQVAALDLGY KPGVEAIRKN PPKVLFLLGA
560 570 580 590 600
DGGCITRQDL PKDCFIIYQG HHGDVGAPIA DVILPGAAYT EKSATYVNTE
610 620 630 640 650
GRAQQTKVAV TPPGLAREDW KIIRALSEIA GMTLPYDTLD QVRNRLEEVS
660 670 680 690 700
PNLVRYDDIE GANYFQQANE LSKLVNQQLL ADPLVPPQLT IKDFYMTDSI
710 720
SRASQTMAKC VKAVTEGAQA VEEPSIC
Length:727
Mass (Da):79,468
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C35F4B8294771FB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HQ205706 Genomic DNA Translation: ADP91534.1
HQ205707 Genomic DNA Translation: ADP91535.1
HQ205708 Genomic DNA Translation: ADP91536.1
HQ205709 Genomic DNA Translation: ADP91537.1
HQ205710 Genomic DNA Translation: ADP91538.1
HQ205711 Genomic DNA Translation: ADP91539.1
HQ205712 Genomic DNA Translation: ADP91540.1
HQ205713 Genomic DNA Translation: ADP91541.1
HQ205714 Genomic DNA Translation: ADP91542.1
HQ205715 Genomic DNA Translation: ADP91543.1
HQ205716 Genomic DNA Translation: ADP91544.1
HQ205717 Genomic DNA Translation: ADP91545.1
HQ205718 Genomic DNA Translation: ADP91546.1
HQ205719 Genomic DNA Translation: ADP91547.1
HQ205720 Genomic DNA Translation: ADP91548.1
HQ205721 Genomic DNA Translation: ADP91549.1
HQ205722 Genomic DNA Translation: ADP91550.1
HQ205723 Genomic DNA Translation: ADP91551.1
HQ205724 Genomic DNA Translation: ADP91552.1
HQ205725 Genomic DNA Translation: ADP91553.1
HQ205726 Genomic DNA Translation: ADP91554.1
HQ205727 Genomic DNA Translation: ADP91555.1
HQ205728 Genomic DNA Translation: ADP91556.1
HQ205729 Genomic DNA Translation: ADP91557.1
HQ205730 Genomic DNA Translation: ADP91558.1
HQ205731 Genomic DNA Translation: ADP91559.1
HQ205732 Genomic DNA Translation: ADP91560.1
HQ205733 Genomic DNA Translation: ADP91561.1
HQ205734 Genomic DNA Translation: ADP91562.1
HQ205735 Genomic DNA Translation: ADP91563.1
HQ205736 Genomic DNA Translation: ADP91564.1
HQ205737 Genomic DNA Translation: ADP91565.1
HQ205738 Genomic DNA Translation: ADP91566.1
HQ205739 Genomic DNA Translation: ADP91567.1
HQ205740 Genomic DNA Translation: ADP91568.1
HQ205741 Genomic DNA Translation: ADP91569.1
HQ205742 Genomic DNA Translation: ADP91570.1
HQ205743 Genomic DNA Translation: ADP91571.1
HQ205744 Genomic DNA Translation: ADP91572.1
HQ205745 Genomic DNA Translation: ADP91573.1
CH471063 Genomic DNA Translation: EAW70380.1

NCBI Reference Sequences

More...
RefSeqi
NP_004997.4, NM_005006.6

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4719

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4719

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205706 Genomic DNA Translation: ADP91534.1
HQ205707 Genomic DNA Translation: ADP91535.1
HQ205708 Genomic DNA Translation: ADP91536.1
HQ205709 Genomic DNA Translation: ADP91537.1
HQ205710 Genomic DNA Translation: ADP91538.1
HQ205711 Genomic DNA Translation: ADP91539.1
HQ205712 Genomic DNA Translation: ADP91540.1
HQ205713 Genomic DNA Translation: ADP91541.1
HQ205714 Genomic DNA Translation: ADP91542.1
HQ205715 Genomic DNA Translation: ADP91543.1
HQ205716 Genomic DNA Translation: ADP91544.1
HQ205717 Genomic DNA Translation: ADP91545.1
HQ205718 Genomic DNA Translation: ADP91546.1
HQ205719 Genomic DNA Translation: ADP91547.1
HQ205720 Genomic DNA Translation: ADP91548.1
HQ205721 Genomic DNA Translation: ADP91549.1
HQ205722 Genomic DNA Translation: ADP91550.1
HQ205723 Genomic DNA Translation: ADP91551.1
HQ205724 Genomic DNA Translation: ADP91552.1
HQ205725 Genomic DNA Translation: ADP91553.1
HQ205726 Genomic DNA Translation: ADP91554.1
HQ205727 Genomic DNA Translation: ADP91555.1
HQ205728 Genomic DNA Translation: ADP91556.1
HQ205729 Genomic DNA Translation: ADP91557.1
HQ205730 Genomic DNA Translation: ADP91558.1
HQ205731 Genomic DNA Translation: ADP91559.1
HQ205732 Genomic DNA Translation: ADP91560.1
HQ205733 Genomic DNA Translation: ADP91561.1
HQ205734 Genomic DNA Translation: ADP91562.1
HQ205735 Genomic DNA Translation: ADP91563.1
HQ205736 Genomic DNA Translation: ADP91564.1
HQ205737 Genomic DNA Translation: ADP91565.1
HQ205738 Genomic DNA Translation: ADP91566.1
HQ205739 Genomic DNA Translation: ADP91567.1
HQ205740 Genomic DNA Translation: ADP91568.1
HQ205741 Genomic DNA Translation: ADP91569.1
HQ205742 Genomic DNA Translation: ADP91570.1
HQ205743 Genomic DNA Translation: ADP91571.1
HQ205744 Genomic DNA Translation: ADP91572.1
HQ205745 Genomic DNA Translation: ADP91573.1
CH471063 Genomic DNA Translation: EAW70380.1
RefSeqiNP_004997.4, NM_005006.6

3D structure databases

SMRiE5KRK5
ModBaseiSearch...

Proteomic databases

PRIDEiE5KRK5

Genome annotation databases

GeneIDi4719
KEGGihsa:4719

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4719

Phylogenomic databases

eggNOGiKOG2282 Eukaryota
COG1034 LUCA
KOiK03934
OrthoDBi1095510at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NDUFS1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4719

Gene expression databases

BgeeiENSG00000023228 Expressed in 242 organ(s), highest expression level in heart
ExpressionAtlasiE5KRK5 baseline and differential

Family and domain databases

CDDicd00207 fer2, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS
IPR010228 NADH_UbQ_OxRdtase_Gsu
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
IPR015405 NuoG_C
PfamiView protein in Pfam
PF00384 Molybdopterin, 1 hit
PF10588 NADH-G_4Fe-4S_3, 1 hit
PF09326 NADH_dhqG_C, 1 hit
SMARTiView protein in SMART
SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMiSSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR01973 NuoG, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS51839 4FE4S_HC3, 1 hit
PS51669 4FE4S_MOW_BIS_MGD, 1 hit
PS00641 COMPLEX1_75K_1, 1 hit
PS00642 COMPLEX1_75K_2, 1 hit
PS00643 COMPLEX1_75K_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5KRK5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5KRK5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 16, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again