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Entry version 70 (07 Oct 2020)
Sequence version 1 (08 Feb 2011)
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Protein

Non-specific serine/threonine protein kinase

Gene

DMPK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseARBA annotation, Transferase
LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMPKImported
ORF Names:hCG_1996612Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000104936.17

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104936, Expressed in heart left ventricle and 204 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E5KR07

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 339Protein kinaseInterPro annotationAdd BLAST269
Domaini340 – 410AGC-kinase C-terminalInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili452 – 525Sequence analysisAdd BLAST74

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961, AGC-kinase_C
IPR011009, Kinase-like_dom_sf
IPR014930, Myotonic_dystrophy_kinase_coil
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08826, DMPK_coil, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E5KR07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASE LAQDKYVADF
60 70 80 90 100
LQWAEPIVVR LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK
110 120 130 140 150
IMNKWDMLKR GEVSCFREER DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY
160 170 180 190 200
YVGGDLLTLL SKFGERIPAE MARFYLAEIV MAIDSVHRLG YVHRDIKPDN
210 220 230 240 250
ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP EILQAVGGGP
260 270 280 290 300
GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP
310 320 330 340 350
LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS
360 370 380 390 400
VPPFTPDFEG ATDTCNFDLV EDGLTAMETL SDIREGAPLG VHLPFVGYSY
410 420 430 440 450
SCMALRDSEV PGPTPMELEA EQLLEPHVQA PSLEPSVSPQ DETAEVAVPA
460 470 480 490 500
AVPAAEAEAE VTLRELQEAL EEEVLTRQSL SREMEAIRTD NQNFASQLRE
510 520 530 540 550
AEARNRDLEA HVRQLQERME LLQAEGATAV TGVPSPRATD PPSHLDGPPA
560 570 580 590 600
VAVGQCPLVG PGPMHRRHLL LPARVPRPGL SEALSLLLFA VVLSRAAALG
610 620
CIGLVAHAGQ LTAVWRRPGA ARAP
Length:624
Mass (Da):69,028
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7ECA31ED9A84E7E1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HQ205626 Genomic DNA Translation: ADP91335.1
HQ205627 Genomic DNA Translation: ADP91339.1
HQ205628 Genomic DNA Translation: ADP91343.1
HQ205629 Genomic DNA Translation: ADP91347.1
HQ205630 Genomic DNA Translation: ADP91351.1
HQ205631 Genomic DNA Translation: ADP91355.1
HQ205632 Genomic DNA Translation: ADP91359.1
HQ205633 Genomic DNA Translation: ADP91363.1
HQ205634 Genomic DNA Translation: ADP91367.1
HQ205635 Genomic DNA Translation: ADP91371.1
HQ205636 Genomic DNA Translation: ADP91375.1
HQ205637 Genomic DNA Translation: ADP91379.1
HQ205638 Genomic DNA Translation: ADP91383.1
HQ205639 Genomic DNA Translation: ADP91387.1
HQ205640 Genomic DNA Translation: ADP91391.1
HQ205641 Genomic DNA Translation: ADP91395.1
HQ205642 Genomic DNA Translation: ADP91399.1
HQ205643 Genomic DNA Translation: ADP91403.1
HQ205644 Genomic DNA Translation: ADP91407.1
HQ205645 Genomic DNA Translation: ADP91411.1
HQ205646 Genomic DNA Translation: ADP91415.1
HQ205647 Genomic DNA Translation: ADP91419.1
HQ205648 Genomic DNA Translation: ADP91423.1
HQ205649 Genomic DNA Translation: ADP91427.1
HQ205650 Genomic DNA Translation: ADP91431.1
HQ205651 Genomic DNA Translation: ADP91435.1
HQ205652 Genomic DNA Translation: ADP91439.1
HQ205653 Genomic DNA Translation: ADP91443.1
HQ205654 Genomic DNA Translation: ADP91447.1
HQ205655 Genomic DNA Translation: ADP91451.1
HQ205656 Genomic DNA Translation: ADP91455.1
HQ205657 Genomic DNA Translation: ADP91459.1
HQ205658 Genomic DNA Translation: ADP91463.1
HQ205659 Genomic DNA Translation: ADP91467.1
HQ205660 Genomic DNA Translation: ADP91471.1
HQ205661 Genomic DNA Translation: ADP91475.1
HQ205662 Genomic DNA Translation: ADP91479.1
HQ205663 Genomic DNA Translation: ADP91483.1
HQ205664 Genomic DNA Translation: ADP91487.1
HQ205665 Genomic DNA Translation: ADP91491.1
CH471126 Genomic DNA Translation: EAW57385.1

NCBI Reference Sequences

More...
RefSeqi
NP_001075029.1, NM_001081560.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1760

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205626 Genomic DNA Translation: ADP91335.1
HQ205627 Genomic DNA Translation: ADP91339.1
HQ205628 Genomic DNA Translation: ADP91343.1
HQ205629 Genomic DNA Translation: ADP91347.1
HQ205630 Genomic DNA Translation: ADP91351.1
HQ205631 Genomic DNA Translation: ADP91355.1
HQ205632 Genomic DNA Translation: ADP91359.1
HQ205633 Genomic DNA Translation: ADP91363.1
HQ205634 Genomic DNA Translation: ADP91367.1
HQ205635 Genomic DNA Translation: ADP91371.1
HQ205636 Genomic DNA Translation: ADP91375.1
HQ205637 Genomic DNA Translation: ADP91379.1
HQ205638 Genomic DNA Translation: ADP91383.1
HQ205639 Genomic DNA Translation: ADP91387.1
HQ205640 Genomic DNA Translation: ADP91391.1
HQ205641 Genomic DNA Translation: ADP91395.1
HQ205642 Genomic DNA Translation: ADP91399.1
HQ205643 Genomic DNA Translation: ADP91403.1
HQ205644 Genomic DNA Translation: ADP91407.1
HQ205645 Genomic DNA Translation: ADP91411.1
HQ205646 Genomic DNA Translation: ADP91415.1
HQ205647 Genomic DNA Translation: ADP91419.1
HQ205648 Genomic DNA Translation: ADP91423.1
HQ205649 Genomic DNA Translation: ADP91427.1
HQ205650 Genomic DNA Translation: ADP91431.1
HQ205651 Genomic DNA Translation: ADP91435.1
HQ205652 Genomic DNA Translation: ADP91439.1
HQ205653 Genomic DNA Translation: ADP91443.1
HQ205654 Genomic DNA Translation: ADP91447.1
HQ205655 Genomic DNA Translation: ADP91451.1
HQ205656 Genomic DNA Translation: ADP91455.1
HQ205657 Genomic DNA Translation: ADP91459.1
HQ205658 Genomic DNA Translation: ADP91463.1
HQ205659 Genomic DNA Translation: ADP91467.1
HQ205660 Genomic DNA Translation: ADP91471.1
HQ205661 Genomic DNA Translation: ADP91475.1
HQ205662 Genomic DNA Translation: ADP91479.1
HQ205663 Genomic DNA Translation: ADP91483.1
HQ205664 Genomic DNA Translation: ADP91487.1
HQ205665 Genomic DNA Translation: ADP91491.1
CH471126 Genomic DNA Translation: EAW57385.1
RefSeqiNP_001075029.1, NM_001081560.2

3D structure databases

SMRiE5KR07
ModBaseiSearch...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2044, 287 antibodies

The DNASU plasmid repository

More...
DNASUi
1760

Genome annotation databases

GeneIDi1760

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1760
EuPathDBiHostDB:ENSG00000104936.17

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1760, 4 hits in 902 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DMPK, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1760

Gene expression databases

BgeeiENSG00000104936, Expressed in heart left ventricle and 204 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR011009, Kinase-like_dom_sf
IPR014930, Myotonic_dystrophy_kinase_coil
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF08826, DMPK_coil, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5KR07_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5KR07
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 7, 2020
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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