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UniProtKB - E5KP26 (E5KP26_HUMAN)

Entry version 84 (02 Dec 2020)
Sequence version 1 (08 Feb 2011)
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Protein

Adenine DNA glycosylase

Gene

MUTYH

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adenine glycosylase active on G-A mispairs.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.UniRule annotationARBA annotation EC:3.2.2.31

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseUniRule annotationARBA annotation, Hydrolase
Biological processDNA damage, DNA repairARBA annotation
Ligand4Fe-4SARBA annotation, Iron, Iron-sulfur, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenine DNA glycosylaseUniRule annotationARBA annotation (EC:3.2.2.31UniRule annotationARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MUTYHImported
ORF Names:hCG_1780049Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000132781.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132781, Expressed in right hemisphere of cerebellum and 224 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E5KP26

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini364 – 495Nudix hydrolaseInterPro annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 51DisorderedSequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Nth/MutY family.UniRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...CDDi		cd03431, DNA_Glycosylase_C, 1 hit
cd00056, ENDO3c, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1670.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011257, DNA_glycosylase
IPR004036, Endonuclease-III-like_CS2
IPR003651, Endonuclease3_FeS-loop_motif
IPR004035, Endouclease-III_FeS-bd_BS
IPR003265, HhH-GPD_domain
IPR000445, HhH_motif
IPR023170, HTH_base_excis_C
IPR029119, MutY_C
IPR015797, NUDIX_hydrolase-like_dom_sf
IPR000086, NUDIX_hydrolase_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00633, HHH, 1 hit
PF00730, HhH-GPD, 1 hit
PF14815, NUDIX_4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00478, ENDO3c, 1 hit
SM00525, FES, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48150, SSF48150, 1 hit
SSF55811, SSF55811, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00764, ENDONUCLEASE_III_1, 1 hit
PS01155, ENDONUCLEASE_III_2, 1 hit
PS51462, NUDIX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E5KP26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPLVSRLSR LWAIMRKPRA AVGSGHRKQA ASQEGRQKHA KNNSQAKPSA 
        60         70         80         90        100
CDGMIAECPG APAGLARQPE EVVLQASVSS YHLFRDVAEV TAFRGSLLSW 
       110        120        130        140        150
YDQEKRDLPW RRRAEDEMDL DRRAYAVWVS EVMLQQTQVA TVINYYTGWM 
       160        170        180        190        200
QKWPTLQDLA SASLEEVNQL WAGLGYYSRG RRLQEGARKV VEELGGHMPR 
       210        220        230        240        250
TAETLQQLLP GVGRYTAGAI ASIAFGQATG VVDGNVARVL CRVRAIGADP 
       260        270        280        290        300
SSTLVSQQLW GLAQQLVDPA RPGDFNQAAM ELGATVCTPQ RPLCSQCPVE 
       310        320        330        340        350
SLCRARQRVE QEQLLASGSL SGSPDVEECA PNTGQCHLCL PPSEPWDQTL 
       360        370        380        390        400
GVVNFPRKAS RKPPREESSA TCVLEQPGAL GAQILLVQRP NSGLLAGLWE 
       410        420        430        440        450
FPSVTWEPSE QLQRKALLQE LQRWAGPLPA THLRHLGEVV HTFSHIKLTY 
       460        470        480        490        500
QVYGLALEGQ TPVTTVPPGA RWLTQEEFHT AAVSTAMKKV FRVYQGQQPG 
       510        520        530        540 
TCMGSKRSQV SSPCSRKKPR MGQQVLDNFF RSHISTDAHS LNSAAQ
Length:546
Mass (Da):60,069
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C79BDB34345DD10
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
HQ205466 Genomic DNA Translation: ADP90935.1
HQ205468 Genomic DNA Translation: ADP90945.1
HQ205469 Genomic DNA Translation: ADP90950.1
HQ205470 Genomic DNA Translation: ADP90955.1
HQ205472 Genomic DNA Translation: ADP90965.1
HQ205473 Genomic DNA Translation: ADP90970.1
HQ205474 Genomic DNA Translation: ADP90975.1
HQ205475 Genomic DNA Translation: ADP90980.1
HQ205476 Genomic DNA Translation: ADP90985.1
HQ205477 Genomic DNA Translation: ADP90990.1
HQ205479 Genomic DNA Translation: ADP91000.1
HQ205480 Genomic DNA Translation: ADP91005.1
HQ205481 Genomic DNA Translation: ADP91010.1
HQ205482 Genomic DNA Translation: ADP91015.1
HQ205483 Genomic DNA Translation: ADP91020.1
HQ205484 Genomic DNA Translation: ADP91025.1
HQ205485 Genomic DNA Translation: ADP91030.1
HQ205486 Genomic DNA Translation: ADP91035.1
HQ205487 Genomic DNA Translation: ADP91040.1
HQ205488 Genomic DNA Translation: ADP91045.1
HQ205489 Genomic DNA Translation: ADP91050.1
HQ205490 Genomic DNA Translation: ADP91055.1
HQ205491 Genomic DNA Translation: ADP91060.1
HQ205492 Genomic DNA Translation: ADP91065.1
HQ205493 Genomic DNA Translation: ADP91070.1
HQ205494 Genomic DNA Translation: ADP91075.1
HQ205495 Genomic DNA Translation: ADP91080.1
HQ205496 Genomic DNA Translation: ADP91085.1
HQ205497 Genomic DNA Translation: ADP91090.1
HQ205498 Genomic DNA Translation: ADP91095.1
HQ205499 Genomic DNA Translation: ADP91100.1
HQ205500 Genomic DNA Translation: ADP91105.1
HQ205501 Genomic DNA Translation: ADP91110.1
HQ205502 Genomic DNA Translation: ADP91115.1
HQ205503 Genomic DNA Translation: ADP91120.1
HQ205505 Genomic DNA Translation: ADP91130.1
CH471059 Genomic DNA Translation: EAX06995.1

NCBI Reference Sequences

More...RefSeqi		NP_036354.1, NM_012222.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4595

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4595

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205466 Genomic DNA Translation: ADP90935.1
HQ205468 Genomic DNA Translation: ADP90945.1
HQ205469 Genomic DNA Translation: ADP90950.1
HQ205470 Genomic DNA Translation: ADP90955.1
HQ205472 Genomic DNA Translation: ADP90965.1
HQ205473 Genomic DNA Translation: ADP90970.1
HQ205474 Genomic DNA Translation: ADP90975.1
HQ205475 Genomic DNA Translation: ADP90980.1
HQ205476 Genomic DNA Translation: ADP90985.1
HQ205477 Genomic DNA Translation: ADP90990.1
HQ205479 Genomic DNA Translation: ADP91000.1
HQ205480 Genomic DNA Translation: ADP91005.1
HQ205481 Genomic DNA Translation: ADP91010.1
HQ205482 Genomic DNA Translation: ADP91015.1
HQ205483 Genomic DNA Translation: ADP91020.1
HQ205484 Genomic DNA Translation: ADP91025.1
HQ205485 Genomic DNA Translation: ADP91030.1
HQ205486 Genomic DNA Translation: ADP91035.1
HQ205487 Genomic DNA Translation: ADP91040.1
HQ205488 Genomic DNA Translation: ADP91045.1
HQ205489 Genomic DNA Translation: ADP91050.1
HQ205490 Genomic DNA Translation: ADP91055.1
HQ205491 Genomic DNA Translation: ADP91060.1
HQ205492 Genomic DNA Translation: ADP91065.1
HQ205493 Genomic DNA Translation: ADP91070.1
HQ205494 Genomic DNA Translation: ADP91075.1
HQ205495 Genomic DNA Translation: ADP91080.1
HQ205496 Genomic DNA Translation: ADP91085.1
HQ205497 Genomic DNA Translation: ADP91090.1
HQ205498 Genomic DNA Translation: ADP91095.1
HQ205499 Genomic DNA Translation: ADP91100.1
HQ205500 Genomic DNA Translation: ADP91105.1
HQ205501 Genomic DNA Translation: ADP91110.1
HQ205502 Genomic DNA Translation: ADP91115.1
HQ205503 Genomic DNA Translation: ADP91120.1
HQ205505 Genomic DNA Translation: ADP91130.1
CH471059 Genomic DNA Translation: EAX06995.1
RefSeqiNP_036354.1, NM_012222.2

3D structure databases

SMRiE5KP26
ModBaseiSearch...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1869, 314 antibodies

Genome annotation databases

GeneIDi4595
KEGGihsa:4595

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4595
EuPathDBiHostDB:ENSG00000132781.17

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4595, 10 hits in 847 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4595

Gene expression databases

BgeeiENSG00000132781, Expressed in right hemisphere of cerebellum and 224 other tissues

Family and domain databases

CDDicd03431, DNA_Glycosylase_C, 1 hit
cd00056, ENDO3c, 1 hit
Gene3Di1.10.1670.10, 1 hit
InterProiView protein in InterPro
IPR011257, DNA_glycosylase
IPR004036, Endonuclease-III-like_CS2
IPR003651, Endonuclease3_FeS-loop_motif
IPR004035, Endouclease-III_FeS-bd_BS
IPR003265, HhH-GPD_domain
IPR000445, HhH_motif
IPR023170, HTH_base_excis_C
IPR029119, MutY_C
IPR015797, NUDIX_hydrolase-like_dom_sf
IPR000086, NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF00633, HHH, 1 hit
PF00730, HhH-GPD, 1 hit
PF14815, NUDIX_4, 1 hit
SMARTiView protein in SMART
SM00478, ENDO3c, 1 hit
SM00525, FES, 1 hit
SUPFAMiSSF48150, SSF48150, 1 hit
SSF55811, SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS00764, ENDONUCLEASE_III_1, 1 hit
PS01155, ENDONUCLEASE_III_2, 1 hit
PS51462, NUDIX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5KP26_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5KP26
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: December 2, 2020
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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