UniProtKB - E5KP25 (E5KP25_HUMAN)
Protein
Adenine DNA glycosylase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Adenine glycosylase active on G-A mispairs.UniRule annotation
Catalytic activityi
- Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.UniRule annotationARBA annotation EC:3.2.2.31
Cofactori
[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-UniRule
- DNA binding Source: InterPro
- hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-UniRule
GO - Biological processi
- base-excision repair Source: UniProtKB-UniRule
Keywordsi
Molecular function | GlycosidaseUniRule annotationARBA annotation, Hydrolase |
Biological process | DNA damage, DNA repairARBA annotation |
Ligand | 4Fe-4SARBA annotation, Iron, Iron-sulfur, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Adenine DNA glycosylaseUniRule annotationARBA annotation (EC:3.2.2.31UniRule annotationARBA annotation) |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000132781.17 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000132781, Expressed in right hemisphere of cerebellum and 224 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 367 – 498 | Nudix hydrolaseInterPro annotationAdd BLAST | 132 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 19 – 47 | DisorderedSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00510000047220 |
OMAi | KRWPTVQ |
OrthoDBi | 616758at2759 |
Family and domain databases
CDDi | cd03431, DNA_Glycosylase_C, 1 hit cd00056, ENDO3c, 1 hit |
Gene3Di | 1.10.1670.10, 1 hit |
InterProi | View protein in InterPro IPR011257, DNA_glycosylase IPR004036, Endonuclease-III-like_CS2 IPR003651, Endonuclease3_FeS-loop_motif IPR004035, Endouclease-III_FeS-bd_BS IPR003265, HhH-GPD_domain IPR000445, HhH_motif IPR023170, HTH_base_excis_C IPR029119, MutY_C IPR015797, NUDIX_hydrolase-like_dom_sf IPR000086, NUDIX_hydrolase_dom |
Pfami | View protein in Pfam PF00633, HHH, 1 hit PF00730, HhH-GPD, 1 hit PF14815, NUDIX_4, 1 hit |
SMARTi | View protein in SMART SM00478, ENDO3c, 1 hit SM00525, FES, 1 hit |
SUPFAMi | SSF48150, SSF48150, 1 hit SSF55811, SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS00764, ENDONUCLEASE_III_1, 1 hit PS01155, ENDONUCLEASE_III_2, 1 hit PS51462, NUDIX, 1 hit |
i Sequence
Sequence statusi: Complete.
E5KP25-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPLVSRLSR LWAIMRKPRA AVGSGHRKQA ASQEGRQKHA KNNSQAKPSA
60 70 80 90 100
CDACAGMIAE CPGAPAGLAR QPEEVVLQAS VSSYHLFRDV AEVTAFRGSL
110 120 130 140 150
LSWYDQEKRD LPWRRRAEDE MDLDRRAYAV WVSEVMLQQT QVATVINYYT
160 170 180 190 200
GWMQKWPTLQ DLASASLEEV NQLWAGLGYY SRGRRLQEGA RKVVEELGGH
210 220 230 240 250
MPRTAETLQQ LLPGVGRYTA GAIASIAFGQ ATGVVDGNVA RVLCRVRAIG
260 270 280 290 300
ADPSSTLVSQ QLWGLAQQLV DPARPGDFNQ AAMELGATVC TPQRPLCSQC
310 320 330 340 350
PVESLCRARQ RVEQEQLLAS GSLSGSPDVE ECAPNTGQCH LCLPPSEPWD
360 370 380 390 400
QTLGVVNFPR KASRKPPREE SSATCVLEQP GALGAQILLV QRPNSGLLAG
410 420 430 440 450
LWEFPSVTWE PSEQLQRKAL LQELQRWAGP LPATHLRHLG EVVHTFSHIK
460 470 480 490 500
LTYQVYGLAL EGQTPVTTVP PGARWLTQEE FHTAAVSTAM KKVFRVYQGQ
510 520 530 540
QPGTCMGSKR SQVSSPCSRK KPRMGQQVLD NFFRSHISTD AHSLNSAAQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ205466 Genomic DNA Translation: ADP90936.1 HQ205468 Genomic DNA Translation: ADP90946.1 HQ205469 Genomic DNA Translation: ADP90951.1 HQ205470 Genomic DNA Translation: ADP90956.1 HQ205472 Genomic DNA Translation: ADP90966.1 HQ205473 Genomic DNA Translation: ADP90971.1 HQ205474 Genomic DNA Translation: ADP90976.1 HQ205475 Genomic DNA Translation: ADP90981.1 HQ205476 Genomic DNA Translation: ADP90986.1 HQ205477 Genomic DNA Translation: ADP90991.1 HQ205479 Genomic DNA Translation: ADP91001.1 HQ205480 Genomic DNA Translation: ADP91006.1 HQ205481 Genomic DNA Translation: ADP91011.1 HQ205482 Genomic DNA Translation: ADP91016.1 HQ205483 Genomic DNA Translation: ADP91021.1 HQ205484 Genomic DNA Translation: ADP91026.1 HQ205485 Genomic DNA Translation: ADP91031.1 HQ205486 Genomic DNA Translation: ADP91036.1 HQ205487 Genomic DNA Translation: ADP91041.1 HQ205488 Genomic DNA Translation: ADP91046.1 HQ205489 Genomic DNA Translation: ADP91051.1 HQ205490 Genomic DNA Translation: ADP91056.1 HQ205491 Genomic DNA Translation: ADP91061.1 HQ205492 Genomic DNA Translation: ADP91066.1 HQ205493 Genomic DNA Translation: ADP91071.1 HQ205494 Genomic DNA Translation: ADP91076.1 HQ205495 Genomic DNA Translation: ADP91081.1 HQ205496 Genomic DNA Translation: ADP91086.1 HQ205497 Genomic DNA Translation: ADP91091.1 HQ205498 Genomic DNA Translation: ADP91096.1 HQ205499 Genomic DNA Translation: ADP91101.1 HQ205500 Genomic DNA Translation: ADP91106.1 HQ205501 Genomic DNA Translation: ADP91111.1 HQ205502 Genomic DNA Translation: ADP91116.1 HQ205503 Genomic DNA Translation: ADP91121.1 HQ205505 Genomic DNA Translation: ADP91131.1 |
RefSeqi | NP_001121897.1, NM_001128425.1 |
Genome annotation databases
GeneIDi | 4595 |
UCSCi | uc009vxp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ205466 Genomic DNA Translation: ADP90936.1 HQ205468 Genomic DNA Translation: ADP90946.1 HQ205469 Genomic DNA Translation: ADP90951.1 HQ205470 Genomic DNA Translation: ADP90956.1 HQ205472 Genomic DNA Translation: ADP90966.1 HQ205473 Genomic DNA Translation: ADP90971.1 HQ205474 Genomic DNA Translation: ADP90976.1 HQ205475 Genomic DNA Translation: ADP90981.1 HQ205476 Genomic DNA Translation: ADP90986.1 HQ205477 Genomic DNA Translation: ADP90991.1 HQ205479 Genomic DNA Translation: ADP91001.1 HQ205480 Genomic DNA Translation: ADP91006.1 HQ205481 Genomic DNA Translation: ADP91011.1 HQ205482 Genomic DNA Translation: ADP91016.1 HQ205483 Genomic DNA Translation: ADP91021.1 HQ205484 Genomic DNA Translation: ADP91026.1 HQ205485 Genomic DNA Translation: ADP91031.1 HQ205486 Genomic DNA Translation: ADP91036.1 HQ205487 Genomic DNA Translation: ADP91041.1 HQ205488 Genomic DNA Translation: ADP91046.1 HQ205489 Genomic DNA Translation: ADP91051.1 HQ205490 Genomic DNA Translation: ADP91056.1 HQ205491 Genomic DNA Translation: ADP91061.1 HQ205492 Genomic DNA Translation: ADP91066.1 HQ205493 Genomic DNA Translation: ADP91071.1 HQ205494 Genomic DNA Translation: ADP91076.1 HQ205495 Genomic DNA Translation: ADP91081.1 HQ205496 Genomic DNA Translation: ADP91086.1 HQ205497 Genomic DNA Translation: ADP91091.1 HQ205498 Genomic DNA Translation: ADP91096.1 HQ205499 Genomic DNA Translation: ADP91101.1 HQ205500 Genomic DNA Translation: ADP91106.1 HQ205501 Genomic DNA Translation: ADP91111.1 HQ205502 Genomic DNA Translation: ADP91116.1 HQ205503 Genomic DNA Translation: ADP91121.1 HQ205505 Genomic DNA Translation: ADP91131.1 |
RefSeqi | NP_001121897.1, NM_001128425.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 15301 |
Protocols and materials databases
Antibodypediai | 1869, 314 antibodies |
Genome annotation databases
GeneIDi | 4595 |
UCSCi | uc009vxp.4, human |
Organism-specific databases
CTDi | 4595 |
EuPathDBi | HostDB:ENSG00000132781.17 |
OpenTargetsi | ENSG00000132781 |
Phylogenomic databases
GeneTreei | ENSGT00510000047220 |
OMAi | KRWPTVQ |
OrthoDBi | 616758at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4595, 10 hits in 847 CRISPR screens |
GenomeRNAii | 4595 |
Gene expression databases
Bgeei | ENSG00000132781, Expressed in right hemisphere of cerebellum and 224 other tissues |
Family and domain databases
CDDi | cd03431, DNA_Glycosylase_C, 1 hit cd00056, ENDO3c, 1 hit |
Gene3Di | 1.10.1670.10, 1 hit |
InterProi | View protein in InterPro IPR011257, DNA_glycosylase IPR004036, Endonuclease-III-like_CS2 IPR003651, Endonuclease3_FeS-loop_motif IPR004035, Endouclease-III_FeS-bd_BS IPR003265, HhH-GPD_domain IPR000445, HhH_motif IPR023170, HTH_base_excis_C IPR029119, MutY_C IPR015797, NUDIX_hydrolase-like_dom_sf IPR000086, NUDIX_hydrolase_dom |
Pfami | View protein in Pfam PF00633, HHH, 1 hit PF00730, HhH-GPD, 1 hit PF14815, NUDIX_4, 1 hit |
SMARTi | View protein in SMART SM00478, ENDO3c, 1 hit SM00525, FES, 1 hit |
SUPFAMi | SSF48150, SSF48150, 1 hit SSF55811, SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS00764, ENDONUCLEASE_III_1, 1 hit PS01155, ENDONUCLEASE_III_2, 1 hit PS51462, NUDIX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E5KP25_HUMAN | |
Accessioni | E5KP25Primary (citable) accession number: E5KP25 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |