UniProtKB - E5KND5 (E5KND5_HUMAN)
Protein
Elongation factor G, mitochondrial
Gene
GFM1
Organism
Homo sapiens (Human)
Status
Functioni
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.UniRule annotation
: polypeptide chain elongation Pathwayi
This protein is involved in the pathway polypeptide chain elongation, which is part of Protein biosynthesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway polypeptide chain elongation and in Protein biosynthesis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 53 – 60 | GTPUniRule annotation | 8 | |
Nucleotide bindingi | 120 – 124 | GTPUniRule annotation | 5 | |
Nucleotide bindingi | 174 – 177 | GTPUniRule annotation | 4 |
GO - Molecular functioni
- GTPase activity Source: UniProtKB-UniRule
- GTP binding Source: UniProtKB-UniRule
- translation elongation factor activity Source: UniProtKB-UniRule
GO - Biological processi
- mitochondrial translational elongation Source: UniProtKB-UniRule
Keywordsi
Molecular function | Elongation factorUniRule annotationImportedARBA annotation |
Biological process | Protein biosynthesis |
Ligand | GTP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00345 |
Names & Taxonomyi
Protein namesi | Recommended name: Elongation factor G, mitochondrialUniRule annotationShort name: EF-GmtUniRule annotation Alternative name(s): Elongation factor G 1, mitochondrialUniRule annotation Short name: mEF-G 1UniRule annotation Elongation factor G1UniRule annotation |
Gene namesi | Name:GFM1UniRule annotationImported Synonyms:EFG1UniRule annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168827.14 |
Subcellular locationi
Mitochondrion
- Mitochondrion UniRule annotation
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000168827, Expressed in endothelial cell and 213 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 321 | Tr-type GInterPro annotationAdd BLAST | 278 |
Sequence similaritiesi
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.ARBA annotation
Phylogenomic databases
HOGENOMi | CLU_002794_4_0_1 |
Family and domain databases
CDDi | cd16262, EFG_III, 1 hit cd01434, EFG_mtEFG1_IV, 1 hit cd04097, mtEFG1_C, 1 hit |
Gene3Di | 3.30.230.10, 1 hit |
HAMAPi | MF_00054_B, EF_G_EF_2_B, 1 hit |
InterProi | View protein in InterPro IPR041095, EFG_II IPR009022, EFG_III IPR035647, EFG_III/V IPR035649, EFG_V IPR000640, EFG_V-like IPR004161, EFTu-like_2 IPR031157, G_TR_CS IPR027417, P-loop_NTPase IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr IPR005225, Small_GTP-bd_dom IPR000795, TF_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR004540, Transl_elong_EFG/EF2 IPR005517, Transl_elong_EFG/EF2_IV |
Pfami | View protein in Pfam PF00679, EFG_C, 1 hit PF14492, EFG_III, 1 hit PF03764, EFG_IV, 1 hit PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SMARTi | View protein in SMART SM00838, EFG_C, 1 hit SM00889, EFG_IV, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF52540, SSF52540, 1 hit SSF54211, SSF54211, 1 hit SSF54980, SSF54980, 2 hits |
TIGRFAMsi | TIGR00484, EF-G, 1 hit TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS00301, G_TR_1, 1 hit PS51722, G_TR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
E5KND5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLLGAAAVA ALGRGRAPAS LGWQRKQVNW KACRWSSSGV IPNEKIRNIG
60 70 80 90 100
ISAHIDSGKT TLTERVLYYT GRIAKMHEVK GKDGVGAVMD SMELERQRGI
110 120 130 140 150
TIQSAATYTM WKDVNINIID TPGHVDFTIE VERALRVLDG AVLVLCAVGG
160 170 180 190 200
VQCQTMTVNR QMKRYNVPFL TFINKLDRMG SNPARALQQM RSKLNHNAAF
210 220 230 240 250
MQIPMGLEGN FKGIVDLIEE RAIYFDGDFG QIVRYGEIPA ELRAAATDHR
260 270 280 290 300
QELIECVANS DEQLGEMFLE EKIPSISDLK LAIRRATLKR SFTPVFLGSA
310 320 330 340 350
LKNKGVQPLL DAVLEYLPNP SEVQNYAILN KEDDSKEKTK ILMNSSRDNS
360 370 380 390 400
HPFVGLAFKL EVGRFGQLTY VRSYQGELKK GDTIYNTRTR KKVRLQRLAR
410 420 430 440 450
MHADMMEDVE EVYAGDICAL FGIDCASGDT FTDKANSGLS MESIHVPDPV
460 470 480 490 500
ISIAMKPSNK NDLEKFSKGI GRFTREDPTF KVYFDTENKE TVISGMGELH
510 520 530 540 550
LEIYAQRLER EYGCPCITGK PKVAFRETIT APVPFDFTHK KQSGGAGQYG
560 570 580 590 600
KVIGVLEPLD PEDYTKLEFS DETFGSNIPK QFVPAVEKGF LDACEKGPLS
610 620 630 640 650
GHKLSGLRFV LQDGAHHMVD SNEISFIRAG EGALKQALAN ATLCILEPIM
660 670 680 690 700
AVEVVAPNEF QGQVIAGINR RHGVITGQDG VEDYFTLYAD VPLNDMFGYS
710 720 730 740 750
TELRSCTEGK GEYTMEYSRY QPCLPSTQED VINKYLEATG QLPVKKGKAK
N
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ205226 Genomic DNA Translation: ADP90694.1 HQ205227 Genomic DNA Translation: ADP90695.1 HQ205229 Genomic DNA Translation: ADP90697.1 HQ205230 Genomic DNA Translation: ADP90698.1 HQ205231 Genomic DNA Translation: ADP90699.1 HQ205234 Genomic DNA Translation: ADP90702.1 HQ205237 Genomic DNA Translation: ADP90705.1 HQ205238 Genomic DNA Translation: ADP90706.1 HQ205240 Genomic DNA Translation: ADP90708.1 HQ205241 Genomic DNA Translation: ADP90709.1 HQ205243 Genomic DNA Translation: ADP90711.1 HQ205244 Genomic DNA Translation: ADP90712.1 HQ205245 Genomic DNA Translation: ADP90713.1 HQ205247 Genomic DNA Translation: ADP90715.1 HQ205248 Genomic DNA Translation: ADP90716.1 HQ205249 Genomic DNA Translation: ADP90717.1 HQ205251 Genomic DNA Translation: ADP90719.1 HQ205252 Genomic DNA Translation: ADP90720.1 HQ205255 Genomic DNA Translation: ADP90723.1 HQ205258 Genomic DNA Translation: ADP90726.1 HQ205261 Genomic DNA Translation: ADP90729.1 HQ205262 Genomic DNA Translation: ADP90730.1 HQ205263 Genomic DNA Translation: ADP90731.1 HQ205264 Genomic DNA Translation: ADP90732.1 HQ205265 Genomic DNA Translation: ADP90733.1 KU178816 mRNA Translation: ALQ34274.1 |
RefSeqi | NP_079272.4, NM_024996.5 |
Genome annotation databases
GeneIDi | 85476 |
KEGGi | hsa:85476 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ205226 Genomic DNA Translation: ADP90694.1 HQ205227 Genomic DNA Translation: ADP90695.1 HQ205229 Genomic DNA Translation: ADP90697.1 HQ205230 Genomic DNA Translation: ADP90698.1 HQ205231 Genomic DNA Translation: ADP90699.1 HQ205234 Genomic DNA Translation: ADP90702.1 HQ205237 Genomic DNA Translation: ADP90705.1 HQ205238 Genomic DNA Translation: ADP90706.1 HQ205240 Genomic DNA Translation: ADP90708.1 HQ205241 Genomic DNA Translation: ADP90709.1 HQ205243 Genomic DNA Translation: ADP90711.1 HQ205244 Genomic DNA Translation: ADP90712.1 HQ205245 Genomic DNA Translation: ADP90713.1 HQ205247 Genomic DNA Translation: ADP90715.1 HQ205248 Genomic DNA Translation: ADP90716.1 HQ205249 Genomic DNA Translation: ADP90717.1 HQ205251 Genomic DNA Translation: ADP90719.1 HQ205252 Genomic DNA Translation: ADP90720.1 HQ205255 Genomic DNA Translation: ADP90723.1 HQ205258 Genomic DNA Translation: ADP90726.1 HQ205261 Genomic DNA Translation: ADP90729.1 HQ205262 Genomic DNA Translation: ADP90730.1 HQ205263 Genomic DNA Translation: ADP90731.1 HQ205264 Genomic DNA Translation: ADP90732.1 HQ205265 Genomic DNA Translation: ADP90733.1 KU178816 mRNA Translation: ALQ34274.1 |
RefSeqi | NP_079272.4, NM_024996.5 |
3D structure databases
SMRi | E5KND5 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | E5KND5, 1 interactor |
Proteomic databases
PRIDEi | E5KND5 |
Protocols and materials databases
Antibodypediai | 46773, 175 antibodies |
Genome annotation databases
GeneIDi | 85476 |
KEGGi | hsa:85476 |
Organism-specific databases
CTDi | 85476 |
EuPathDBi | HostDB:ENSG00000168827.14 |
Phylogenomic databases
HOGENOMi | CLU_002794_4_0_1 |
Enzyme and pathway databases
UniPathwayi | UPA00345 |
Miscellaneous databases
BioGRID-ORCSi | 85476, 388 hits in 846 CRISPR screens |
ChiTaRSi | GFM1, human |
GenomeRNAii | 85476 |
Gene expression databases
Bgeei | ENSG00000168827, Expressed in endothelial cell and 213 other tissues |
Family and domain databases
CDDi | cd16262, EFG_III, 1 hit cd01434, EFG_mtEFG1_IV, 1 hit cd04097, mtEFG1_C, 1 hit |
Gene3Di | 3.30.230.10, 1 hit |
HAMAPi | MF_00054_B, EF_G_EF_2_B, 1 hit |
InterProi | View protein in InterPro IPR041095, EFG_II IPR009022, EFG_III IPR035647, EFG_III/V IPR035649, EFG_V IPR000640, EFG_V-like IPR004161, EFTu-like_2 IPR031157, G_TR_CS IPR027417, P-loop_NTPase IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr IPR005225, Small_GTP-bd_dom IPR000795, TF_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR004540, Transl_elong_EFG/EF2 IPR005517, Transl_elong_EFG/EF2_IV |
Pfami | View protein in Pfam PF00679, EFG_C, 1 hit PF14492, EFG_III, 1 hit PF03764, EFG_IV, 1 hit PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SMARTi | View protein in SMART SM00838, EFG_C, 1 hit SM00889, EFG_IV, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF52540, SSF52540, 1 hit SSF54211, SSF54211, 1 hit SSF54980, SSF54980, 2 hits |
TIGRFAMsi | TIGR00484, EF-G, 1 hit TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS00301, G_TR_1, 1 hit PS51722, G_TR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E5KND5_HUMAN | |
Accessioni | E5KND5Primary (citable) accession number: E5KND5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |